Patents by Inventor Tomomitsu Miyagaki

Tomomitsu Miyagaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF EXPANDING AND ASSESSING B CELLS AND USING EXPANDED B CELLS TO TREAT DISEASE
    Publication number: 20200283727
    Abstract: Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
    Type: Application
    Filed: March 20, 2020
    Publication date: September 10, 2020
    Applicant: DUKE UNIVERSITY
    Inventors: Thomas F. Tedder, Ayumi Yoshizaki, Tomomitsu Miyagaki, Evgueni Kountikov, Jonathan C. Poe
  • Methods of expanding and assessing B cells and using expanded B cells to treat disease
    Patent number: 10611999
    Abstract: Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: April 7, 2020
    Assignee: Duke University
    Inventors: Thomas F. Tedder, Ayumi Yoshizaki, Tomomitsu Miyagaki, Evgueni Kountikov, Jonathan C. Poe
  • METHODS FOR EXPANDING AND DIFFERENTIATING B CELLS FOR PRODUCING ANTIBODY
    Publication number: 20190352607
    Abstract: Provided are feeder cell lines that can be used to expand and differentiate B cells in vitro, a method for expanding B cells in vitro comprising culturing the B cells with the feeder cell line, and a method for producing monoclonal antibody in vitro comprising culturing a single B cell with the feeder cell line under sufficient conditions and for sufficient time to induce expansion and differentiation of the B cell into a B cell done secreting antibody.
    Type: Application
    Filed: February 16, 2017
    Publication date: November 21, 2019
    Applicant: Duke University
    Inventors: Hiraku SUGA, Kathleen M. CANDANDO, Evgueni KOUNTIKOV, Masahiro KAMATA, Thomas F. TEDDER, Ayumi YOSHIZAKI, Tomomitsu MIYAGAKI
  • METHODS OF EXPANDING AND ASSESSING B CELLS AND USING EXPANDED B CELLS TO TREAT DISEASE
    Publication number: 20180291340
    Abstract: Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
    Type: Application
    Filed: June 5, 2018
    Publication date: October 11, 2018
    Applicant: DUKE UNIVERSITY
    Inventors: Thomas F. Tedder, Ayumi Yoshizaki, Tomomitsu Miyagaki, Evgueni Kountikov, Jonathan C. Poe
  • Methods of expanding and assessing B cells and using expanded B cells to treat disease
    Patent number: 10017739
    Abstract: Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: July 10, 2018
    Assignee: DUKE UNIVERSITY
    Inventors: Thomas F. Tedder, Ayumi Yoshizaki, Tomomitsu Miyagaki, Evgueni Kountikov, Jonathan C. Poe
  • METHODS OF EXPANDING AND ASSESSING B CELLS AND USING EXPANDED B CELLS TO TREAT DISEASE
    Publication number: 20140065118
    Abstract: Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
    Type: Application
    Filed: March 12, 2013
    Publication date: March 6, 2014
    Inventors: Thomas F. Tedder, Ayumi Yoshizaki, Tomomitsu Miyagaki, Evgueni Kountikov, Jonathan C. Poe