Patents by Inventor Tomonori Hidesaki

Tomonori Hidesaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200149079
    Abstract: Provided are a recombinant microorganism comprising: a gene encoding a pyridoxine oxidase; and a gene encoding a pyridoxamine synthetase having an enzymatic activity of synthesizing pyridoxamine from pyridoxal, in which each of the gene encoding a pyridoxine oxidase and the gene encoding a pyridoxamine synthetase is introduced from outside of a bacterial cell, or is endogenous to the bacterial cell and has an enhanced expression, and a method of producing pyridoxamine or a salt thereof from pyridoxine or a salt thereof using the recombinant microorganism.
    Type: Application
    Filed: May 11, 2018
    Publication date: May 14, 2020
    Applicants: Mitsui Chemicals, Inc., RENASCIENCE CO., LTD
    Inventors: Toshihiro TATENO, Tomonori HIDESAKI, Tadashi ARAKI, Atsunori SHINDO, Yoshiko MATSUMOTO, Toshio MIYATA, Masaru HONJO
  • Publication number: 20200123581
    Abstract: A recombinant microorganism includes a gene encoding a pyridoxine dehydrogenase, a gene encoding a pyridoxamine synthetase having an enzymatic activity of synthesizing pyridoxamine from pyridoxal, and a gene encoding an amino acid regeneration enzyme having an enzymatic activity of regenerating an amino acid consumed by the pyridoxamine synthetase, in which at least two of the gene encoding the pyridoxine dehydrogenase, the gene encoding the pyridoxamine synthetase, or the gene encoding the amino acid regeneration enzyme, are introduced from outside of a bacterial cell, or are endogenous to the bacterial cell and have an enhanced expression. In addition, a recombinant microorganism into which a gene encoding a pyridoxine dehydrogenase is introduced is provided.
    Type: Application
    Filed: May 11, 2018
    Publication date: April 23, 2020
    Applicants: Mitsui Chemicals, Inc., RENASCIENCE CO., LTD
    Inventors: Toshihiro TATENO, Motoi YOKOTA, Tomonori HIDESAKI, Tadashi ARAKI, Atsunori SHINDO, Yoshiko MATSUMOTO, Toshio MIYATA, Masaru HONJO
  • Patent number: 10294505
    Abstract: Disclosed is an acetyl-CoA-producing microorganism, which is obtained by imparting malate thiokinase and malyl-CoA lyase enzymatic activities to a microorganism having none of the following (a), (b), (c) or (d), without imparting any of (a), (b), (c) or (d), or, even when one or more of (a), (b), (c) or (d) are imparted, not allowing the functions thereof to be exerted: (a) a carbon dioxide fixation cycle having an enzymatic reaction from malonyl-CoA to malonate semialdehyde or 3-hydroxypropionate, (b) a carbon dioxide fixation cycle having an enzymatic reaction from acetyl-CoA and CO2 to pyruvate, (c) a carbon dioxide fixation cycle having an enzymatic reaction from crotonyl-CoA and CO2 to ethylmalonyl-CoA or glutaconyl-CoA or (d) a carbon dioxide fixation cycle having an enzymatic reaction from CO2 to formate.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: May 21, 2019
    Assignee: MITSUI CHEMCIALS, INC.
    Inventors: Anjali Madhavan, Ryota Fujii, Tomonori Hidesaki, Su Sun Chong
  • Patent number: 10221435
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: March 5, 2019
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Tadashi Araki, Tomonori Hidesaki, Seiichi Watanabe, Keita Nishida, Kiyoteru Nagahara, Mitsuo Koito
  • Patent number: 9828618
    Abstract: An acetyl-CoA producing microorganism obtained by imparting at least one enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism that does not have any of the following (a), (b), (c), (d) or (e): (a) a carbon dioxide fixation cycle including an enzymatic reaction from malonyl-CoA to malonate semialdehyde or 3-hydroxypropionate; (b) a carbon dioxide fixation cycle including an enzymatic reaction from acetyl-CoA and CO2 to pyruvate; (c) a carbon dioxide fixation cycle including an enzymatic reaction from crotonyl-CoA and CO2 to ethylmalonyl-CoA or glutaconyl-CoA; (d) a carbon dioxide fixation cycle including an enzymatic reaction from CO2 to formate; or (e) at least one selected from the group consisting of malate thiokinase and malyl-CoA lyase.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: November 28, 2017
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Tomonori Hidesaki, Ryota Fujii, Yoshiko Matsumoto, Anjali Madhavan, Su Sun Chong
  • Patent number: 9822387
    Abstract: An acetyl-CoA-producing microorganism, which is capable of efficiently synthesizing acetyl-CoA using carbon dioxide, and a substance production method using the same are provided. An acetyl-CoA-producing microorganism including an acetyl-CoA production cycle obtained by imparting at least one type of enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: November 21, 2017
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Ryota Fujii, Tomokazu Shirai, Tadashi Araki, Koh Amano, Yoshiko Matsumoto, Toshihiro Tateno, Nozomi Takebayashi, Takashi Morishige, Hitoshi Takahashi, Mitsufumi Wada, Hiroshi Shimizu, Chikara Furusawa, Takashi Hirasawa, Tomonori Hidesaki, Ayako Endo, Dominik Lukas Jürgen-Lohmann, Anjali Madhavan, Su Sun Chong
  • Publication number: 20170327853
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Application
    Filed: June 6, 2017
    Publication date: November 16, 2017
    Applicant: Mitsui Chemicals, Inc.
    Inventors: Tadashi ARAKI, Tomonori HIDESAKI, Seiichi WATANABE, Keita NISHIDA, Kiyoteru NAGAHARA, Mitsuo KOITO
  • Patent number: 9765369
    Abstract: A mutant lysine decarboxylase produced by replacing at least one of the amino acids in SEQ ID NO:4 with another amino acid.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: September 19, 2017
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Daisuke Mochizuki, Tadashi Araki, Akiko Natsuji, Tomomi Sakai, Tomonori Hidesaki
  • Patent number: 9695452
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: July 4, 2017
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Tadashi Araki, Tomonori Hidesaki, Seiichi Watanabe, Keita Nishida, Kiyoteru Nagahara, Mitsuo Koito
  • Patent number: 9404132
    Abstract: In a method for producing 1,5-pentamethylenediamine, a lysine decarboxylase-expressing microorganism that is subjected to a treatment is used.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: August 2, 2016
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Tomonori Hidesaki, Akiko Natsuji, Toshihiko Nakagawa, Goro Kuwamura, Daisuke Hasegawa, Satoshi Yamasaki, Kuniaki Sato, Hiroshi Takeuchi
  • Publication number: 20160046970
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Application
    Filed: October 30, 2015
    Publication date: February 18, 2016
    Applicant: MITSUI CHEMICALS, INC.
    Inventors: Tadashi ARAKI, Tomonori HIDESAKI, Seiichi WATANABE, Keita NISHIDA, Kiyoteru NAGAHARA, Mitsuo KOITO
  • Patent number: 9212376
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: December 15, 2015
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Tadashi Araki, Tomonori Hidesaki, Seiichi Watanabe, Keita Nishida, Kiyoteru Nagahara, Mitsuo Koito
  • Publication number: 20150218607
    Abstract: Disclosed is an acetyl-CoA-producing microorganism, which is obtained by imparting malate thiokinase and malyl-CoA lyase enzymatic activities to a microorganism having none of the following (a), (b), (c) or (d), without imparting any of (a), (b), (c) or (d), or, even when one or more of (a), (b), (c) or (d) are imparted, not allowing the functions thereof to be exerted: (a) a carbon dioxide fixation cycle having an enzymatic reaction from malonyl-CoA to malonate semialdehyde or 3-hydroxypropionate, (b) a carbon dioxide fixation cycle having an enzymatic reaction from acetyl-CoA and CO2 to pyruvate, (c) a carbon dioxide fixation cycle having an enzymatic reaction from crotonyl-CoA and CO2 to ethylmalonyl-CoA or glutaconyl-CoA or (d) a carbon dioxide fixation cycle having an enzymatic reaction from CO2 to formate.
    Type: Application
    Filed: January 23, 2014
    Publication date: August 6, 2015
    Applicant: Mitsui Chemicals, Inc.
    Inventors: Anjali Madhavan, Ryota Fujii, Tomonori Hidesaki, Su Sun Chong
  • Publication number: 20150132808
    Abstract: A mutant lysine decarboxylase is produced by replacing at least one of the amino-acids in the amino acid sequence shown in sequence ID No. 4 of the sequence listing with another amino-acid.
    Type: Application
    Filed: January 17, 2013
    Publication date: May 14, 2015
    Inventors: Daisuke Mochizuki, Tadashi Araki, Akiko Natsuji, Tomomi Sakai, Tomonori Hidesaki
  • Publication number: 20150111261
    Abstract: An L-threonine-producing Escherichia coli including a pathway selected from the group consisting of a pathway that produces acetaldehyde from acetyl-CoA with acetaldehyde dehydrogenase, and a pathway that produces L-threonine from acetaldehyde and glycine with threonine aldolase, and a pathway that produces 2-amino-3-oxobutyrate from glycine and acetyl-CoA with glycine C-acetyltransferase, and a pathway that produces L-threonine from 2-amino-3-oxobutyrate with threonine dehydrogenase.
    Type: Application
    Filed: October 21, 2013
    Publication date: April 23, 2015
    Applicant: Mitsui Chemicals, Inc.
    Inventors: Dominik Lukas JURGEN-LOHMANN, Ryota Fujii, Tomonori Hidesaki
  • Publication number: 20140363847
    Abstract: An acetyl-CoA-producing microorganism, which is capable of efficiently synthesizing acetyl-CoA using carbon dioxide, and a substance production method using the same are provided. An acetyl-CoA-producing microorganism including an acetyl-CoA production cycle obtained by imparting at least one type of enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism.
    Type: Application
    Filed: July 27, 2012
    Publication date: December 11, 2014
    Inventors: Ryota Fujii, Tomokazu Shirai, Tadashi Araki, Koh Amano, Yoshiko Matsumoto, Toshihiro Tateno, Nozomi Takebayashi, Takashi Morishige, Hitoshi Takahashi, Mitsufumi Wada, Hiroshi Shimizu, Chikara Furusawa, Takashi Hirasawa, Tomonori Hidesaki, Ayako Endo, Dominik Lukas Jürgen-Lohmann, Anjali Madhavan
  • Patent number: 8895270
    Abstract: Disclosed is a method for producing a ?-amino acid comprising a step of synthesizing a ?-amino acid from an ?-amino acid in the presence of an amino acid aminomutase. In this method, a ?-amino acid is precipitated as a solid in the reaction solution.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: November 25, 2014
    Assignee: Mitsui Chemicals, Inc.
    Inventor: Tomonori Hidesaki
  • Publication number: 20130079486
    Abstract: In a method for producing 1,5-pentamethylenediamine, a lysine decarboxylase-expressing microorganism that is subjected to a treatment is used.
    Type: Application
    Filed: February 25, 2011
    Publication date: March 28, 2013
    Inventors: Tomonori Hidesaki, Akiko Natsuji, Toshihiko Nakagawa, Goro Kuwamura, Daisuke Hasegawa, Satoshi Yamasaki, Kuniaki Sato, Hiroshi Takeuchi
  • Publication number: 20120077233
    Abstract: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Application
    Filed: February 24, 2011
    Publication date: March 29, 2012
    Applicant: Mitsui Chemicals, Inc.
    Inventors: Tadashi Araki, Tomonori Hidesaki, Seiichi Watanabe, Keita Nishida, Kiyoteru Nagahara, Mitsuo Koito
  • Patent number: 7919285
    Abstract: This invention relates to DNA encoding an enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: April 5, 2011
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Tadashi Araki, Tomonori Hidesaki, Seiichi Watanabe, Keita Nishida, Kiyoteru Nagahara, Mitsuo Koito