Patents by Inventor Tomonori Kimura
Tomonori Kimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240304331Abstract: Provided is a method for further improving therapeutic effect and cost efficiency by ascertaining cancer type and treatment responsiveness for individual patients. The invention provides a method which includes providing information regarding cancer type of a subject, comprising assessing the cancer type of the subject using a marker relating to the amount of a D-amino acid in blood of the subject, and providing information relating to the cancer type of the subject, based on the assessment results, as well as a system for providing information pertaining to cancer in a subject, which carries out the method.Type: ApplicationFiled: March 7, 2024Publication date: September 12, 2024Applicants: Kagami Inc., National Institutes of Biomedical Innovation, Health and Nutrition, Osaka UniversityInventors: Atsunari Kawashima, Norio Nonomura, Ryoichi Imamura, Akinaru Yamamoto, Tomonori Kimura, Masashi Mita
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Patent number: 12078614Abstract: An ultrasound probe includes: a metal case including a bottom wall portion having a vibration surface, and a side wall portion connected to the bottom wall portion; a coil mounted on one surface of the side wall portion; and a magnet mounted in such a way as to sandwich the coil between the magnet and the one surface of the side wall portion, in which the coil causes an eddy current to occur in the one surface of the side wall portion, and causes the bottom wall portion to vibrate, by using a Lorentz force occurring in the side wall portion because of the interaction between the eddy current and a magnetic field generated by the magnet.Type: GrantFiled: April 5, 2022Date of Patent: September 3, 2024Assignee: MITSUBISHI ELECTRIC CORPORATIONInventors: Koji Ibata, Rokuzo Hara, Tomonori Kimura, Yasuhiro Nishioka
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Publication number: 20240145091Abstract: Provided herein is a method for modulating the amount of virus in a subject comprising administering to the subject an agent for controlling an indicator associated with a D-amino acid in the subject.Type: ApplicationFiled: October 17, 2023Publication date: May 2, 2024Applicants: National Institutes of Biomedical Innovation, Health and Nutrition, Kagami Inc.Inventors: Tomonori KIMURA, Shihoko KIMURA, Yasuhiro YASUTOMI, Masamitsu ASAKA, Emiko URANO, Daichi UTSUMI, Masashi MITA
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Publication number: 20240127956Abstract: Provided herein is a method for providing information about virus infection and/or virus infection disease in a subject, comprising: making a determination on the detection and/or stage classification of virus infection and/or virus infection disease in the subject using an indicator associated with a D-amino acid in the subject; and providing information about virus infection and/or virus infection disease in the subject based on the results of the determination.Type: ApplicationFiled: October 17, 2023Publication date: April 18, 2024Applicants: Osaka University, National Institutes of Biomedical Innovation, Health and Nutrition, Kagami Inc.Inventors: Yoshitaka ISAKA, Tomonori KIMURA, Shihoko KIMURA, Masashi MITA
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Patent number: 11913828Abstract: A test object includes a sensor housing for vibrating together with a test object in synchronism with vibration of the test object; a piezoelectric substrate for vibrating together with the sensor housing in synchronism with vibration of the sensor housing, where a first interdigital electrode, a first terminal, a second interdigital electrode, and a second terminal are disposed on a first surface of the piezoelectric substrate, and the piezoelectric substrate is disposed inside the sensor housing to be fixed to the sensor housing; an amplifier for receiving a signal output from the second terminal as an input signal, amplifying the received input signal, and transmitting the input signal after the amplification to the first terminal as an output signal; a deformable layer being elastic and having a first surface adhered to a second surface of the piezoelectric substrate; and a heavy object having a first surface adhered to a second surface of the deformable layer.Type: GrantFiled: October 19, 2021Date of Patent: February 27, 2024Assignee: Mitsubishi Electric CorporationInventors: Rokuzo Hara, Tomonori Kimura, Koji Ibata, Yasuhiro Nishioka
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Patent number: 11852521Abstract: Disclosed is a vibration sensor including a piezoelectric substrate, a first electrode and a second electrode that are arranged on the piezoelectric substrate, an amplifier electrically connected between the first electrode and the second electrode, and a solid medium having a first surface part in contact with the piezoelectric substrate, and a second surface part disposed opposite to the first surface part and used for contact with a target substance, the solid medium having a sound speed lower than the phase speed of a plate wave in the piezoelectric substrate, in which an oscillation loop includes the piezoelectric substrate, the first electrode, the second electrode, the amplifier, and the solid medium, and a vibration of the target substance is detected as a result of variation in the loop length of the oscillation loop in response to the vibration of the target substance.Type: GrantFiled: September 13, 2021Date of Patent: December 26, 2023Assignee: MITSUBISHI ELECTRIC CORPORATIONInventors: Tomonori Kimura, Rokuzo Hara
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Publication number: 20230304132Abstract: Provided are: a wear-resistant member using a Cr-based alloy material in which the cost can be reduced as compared with a Co-based alloy material and has wear resistance superior to that of the conventional Co-based alloy material; and a mechanical device using the wear-resistant member. The present invention is a wear-resistant member using a Cr-based alloy material, in which the Cr-based alloy material includes: more than 40 mass % and 65 mass % or less of Cr; 15 mass % or more and 40 mass % or less of Ni; more than 0 mass % and 30 mass % or less of Fe; 5 mass % or more and 16 mass % or less of Nb; 0.1 mass % or more and 0.9 mass % or less of Ti; 0.6 mass % or more and 2.5 mass % or less of C; 2 mass % or less of Mn; and impurities, and in which a mass ratio Ti/Nb of the Nb and the Ti is 0.063 or less.Type: ApplicationFiled: June 9, 2021Publication date: September 28, 2023Applicant: Hitachi, Ltd.Inventors: Mitsuru HASEGAWA, Tomonori KIMURA, Masafumi NOUJIMA
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Publication number: 20230220387Abstract: The present invention provides a D-serine transport modifier which is characterized by controlling the transport of D-serine into and out of cells by a D-serine transporter protein, a pharmaceutical composition which comprises the same as an active component and treats or prevents diseases relating to an increase or decrease in the amount of D-serine, and a screening method of substances that control the transport of D-serine. The present invention also provides a screening method of a D-serine transporter protein.Type: ApplicationFiled: December 25, 2020Publication date: July 13, 2023Applicants: Kagami Inc., Public University Corporation Nara Medical University, National Institutes of Biomedical Innovation, Health and NutritionInventors: Masashi MITA, Rikako SUZUKI, Shushi NAGAMORI, Pattama WIRIYASERMKUL, Pornparn KONGPRACHA, Satomi MORIYAMA, Tomonori KIMURA
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Publication number: 20230037869Abstract: The present invention provides a method comprising a step of estimating the kidney function of an arbitrary subject by a regression analysis which employs the amount of a D, L-amino acid in a biological sample from the arbitrary subject as an explanatory variable and employs the amount of filtrated glomeruli in the arbitrary subject as an object variable, by employing a previously determined formula (I): Y=a1·X1+a2·X2+ . . . +an·Xn+b (I) [wherein a1 to an independently represent a constant obtained by the regression analysis; X1 to Xn independently represent a variable of the amount of the D,L-amino acid which is selected by the regression analysis; and b represents a constant obtained by the regression analysis] on the basis of the Y value calculated from the amount of the D, L-amino acid in the biological sample from the object to be evaluated. Also provided is a system for carrying out the method.Type: ApplicationFiled: December 25, 2020Publication date: February 9, 2023Applicants: Kagami Inc., National Institutes of Biomedical Innovation, Health and NutritionInventors: Masashi MITA, Tatsuhiko IKEDA, Tomonori KIMURA
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Publication number: 20220341002Abstract: An object of the present invention is to provide a Zr—Nb-based alloy material as a low-magnetic susceptibility alloy having a high corrosion resistance while maintaining a magnetic susceptibility equivalent to or less than the magnetic susceptibility of the biological alloy of the related art, a method for manufacturing the alloy material, and a Zr—Nb-based alloy product. The Zr—Nb-based alloy material according to the present invention includes, as a chemical composition, 3% by mass or more and 18% by mass or less of Nb, 12% by mass or less of Ti, 6% by mass or less of Cr, 6% by mass or less of Cu, 5% by mass or less of Bi, and a remainder consisting of Zr and unavoidable impurities, in which isothermal ? phase particles are dispersed and precipitated in ? phase crystal grains of a parent phase.Type: ApplicationFiled: September 29, 2020Publication date: October 27, 2022Applicant: Hitachi Metals, Ltd.Inventors: Shinya TAMURA, Tomonori KIMURA, Yasuhisa AONO
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Publication number: 20220252610Abstract: The present invention provides a method for assisting in the evaluation of the condition of kidneys, a system for evaluating the condition of kidneys, and a program for evaluating the condition of kidneys, using, as an index, the ratio of reabsorption of D-serine and/or D-asparagine in target kidneys and excretion of the D-serine and/or D-asparagine. The present invention also provides a method for monitoring the condition of kidneys and a method for monitoring the effect of treatment on kidney disease.Type: ApplicationFiled: March 23, 2020Publication date: August 11, 2022Applicants: Kagami Inc., National Institutes of Biomedical, Innovation, Health and NutritionInventors: Masashi MITA, Tatsuhiko IKEDA, Tomonori KIMURA
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Publication number: 20220229021Abstract: An ultrasound probe includes: a metal case including a bottom wall portion having a vibration surface, and a side wall portion connected to the bottom wall portion; a coil mounted on one surface of the side wall portion; and a magnet mounted in such a way as to sandwich the coil between the magnet and the one surface of the side wall portion, in which the coil causes an eddy current to occur in the one surface of the side wall portion, and causes the bottom wall portion to vibrate, by using a Lorentz force occurring in the side wall portion because of the interaction between the eddy current and a magnetic field generated by the magnet.Type: ApplicationFiled: April 5, 2022Publication date: July 21, 2022Applicant: Mitsubishi Electric CorporationInventors: Koji IBATA, Rokuzo HARA, Tomonori KIMURA, Yasuhiro NISHIOKA
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Publication number: 20220170945Abstract: The present invention provides: a method for assisting the evaluation of renal pathological conditions, said method comprising using, as an index, a combination of renal reabsorption and excretion ratios of D-serine and/or D-asparagine in a subject with the blood D-serine and/or D-asparagine levels; a system for evaluating renal pathological conditions; and a program for evaluating renal pathological conditions. The present invention also provides: a method for monitoring renal pathological conditions; and a method for monitoring an effect of treating a renal disease.Type: ApplicationFiled: March 23, 2020Publication date: June 2, 2022Applicants: Kagami Inc., National Institutes of Biomedical, Innovation, Health and NutritionInventors: Masashi MITA, Tatsuhiko IKEDA, Tomonori KIMURA
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Patent number: 11307174Abstract: An ultrasonic probe (1) sends out ultrasound waves to a steel sheet (100) obliquely at a plurality of angles, using transmission signals provided from a transmission signal processing unit (3a). In addition, the ultrasonic probe (1) receives echoes corresponding to the plurality of angles from the steel sheet (100). A reception signal processing unit (3b) determines amplitudes of the echoes received by the ultrasonic probe (1) and corresponding to the plurality of angles, and periods of time from when the ultrasound waves are sent out until the echoes are received, as reception times, and identifies a location of a flaw (101) in the steel sheet (100) from the reception times and a ratio between the amplitudes.Type: GrantFiled: December 7, 2017Date of Patent: April 19, 2022Assignee: MITSUBISHI ELECTRIC CORPORATIONInventors: Tomonori Kimura, Tomonobu Gotou, Yoshiaki Kunii, Hisashi Udagawa, Akira Hosoya
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Publication number: 20220034711Abstract: A test object includes a sensor housing for vibrating together with a test object in synchronism with vibration of the test object; a piezoelectric substrate for vibrating together with the sensor housing in synchronism with vibration of the sensor housing, where a first interdigital electrode, a first terminal, a second interdigital electrode, and a second terminal are disposed on a first surface of the piezoelectric substrate, and the piezoelectric substrate is disposed inside the sensor housing to be fixed to the sensor housing; an amplifier for receiving a signal output from the second terminal as an input signal, amplifying the received input signal, and transmitting the input signal after the amplification to the first terminal as an output signal; a deformable layer being elastic and having a first surface adhered to a second surface of the piezoelectric substrate; and a heavy object having a first surface adhered to a second surface of the deformable layer.Type: ApplicationFiled: October 19, 2021Publication date: February 3, 2022Applicant: Mitsubishi Electric CorporationInventors: Rokuzo HARA, Tomonori KIMURA, Koji IBATA, Yasuhiro NISHIOKA
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Publication number: 20220003774Abstract: The purpose of the present invention is to provide: a method for predicting the prognosis for kidney disease for a subject on the basis of the amount of D- and L-amino acids, from a blood sample; and an analysis system that determines prognosis predictions. This purpose is achieved by using at least one amino acid to predict the prognosis for kidney disease, said amino acid being selected from the group consisting of D-serine, D-asparagine, D-proline, D-alanine, D-leucine, D-lysine, D-allo-isoleucine, L-glutamic acid, L-alanine, L-tryptophan, and L-asparagine.Type: ApplicationFiled: July 13, 2021Publication date: January 6, 2022Applicants: Osaka University, Kagami Inc.Inventors: Yoshitaka ISAKA, Tomonori KIMURA, Keiko YASUDA, Kenji Hamase, Masashi MITA
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Publication number: 20210404866Abstract: Disclosed is a vibration sensor including a piezoelectric substrate, a first electrode and a second electrode that are arranged on the piezoelectric substrate, an amplifier electrically connected between the first electrode and the second electrode, and a solid medium having a first surface part in contact with the piezoelectric substrate, and a second surface part disposed opposite to the first surface part and used for contact with a target substance, the solid medium having a sound speed lower than the phase speed of a plate wave in the piezoelectric substrate, in which an oscillation loop includes the piezoelectric substrate, the first electrode, the second electrode, the amplifier, and the solid medium, and a vibration of the target substance is detected as a result of variation in the loop length of the oscillation loop in response to the vibration of the target substance.Type: ApplicationFiled: September 13, 2021Publication date: December 30, 2021Applicant: Mitsubishi Electric CorporationInventors: Tomonori KIMURA, Rokuzo HARA
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Patent number: 11193912Abstract: An ultrasonic measurement apparatus (1) estimates a property/state of a test object (100) that allows an injected ultrasonic wave to propagate as plate waves (UW) of propagation modes. The ultrasonic measurement apparatus (1) includes: a receiver (30) configured to receive a detected signal obtained by detecting the plate waves (UW) propagating through the test object (100) to output a received signal indicating a time-domain waveform of the detected signal; an intensity detector (12) configured to detect the signal intensity of a waveform part corresponding to a first propagation mode, and the signal intensity of a waveform part corresponding to a second propagation mode; and an estimator (13) configured to make a comparison between the signal intensities to estimate a property/state of the test object (100) on the basis of a result of the comparison.Type: GrantFiled: January 31, 2017Date of Patent: December 7, 2021Assignee: MITSUBISHI ELECTRIC CORPORATIONInventor: Tomonori Kimura
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Publication number: 20210373031Abstract: The present invention provides a method for determining glomerular filtration ability on the basis of the amount of D-serine in the blood. The present invention provides a blood analysis system which includes a storage unit, an analysis measurement unit, a data processing unit and a glomerular filtration ability output unit, wherein: the storage unit stores the correlation equation between the amount of D-serine in the blood and glomerular filtration ability; the analysis measurement unit separates and quantifies the amount of D-serine in the blood; the data processing unit calculates glomerular filtration ability by inputting the D-serine amount into the correlation equation stored in the storage unit; and a pathology information output unit outputs glomerular filtration ability information.Type: ApplicationFiled: October 17, 2019Publication date: December 2, 2021Applicants: Kagami Inc., National Institutes of Biomedical, Innovation, Health and NutritionInventors: Masashi MITA, Tatsuhiko IKEDA, Tomonori KIMURA
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Patent number: 11180833Abstract: There is provided a Cr-based two-phase alloy including two phases of a ferrite phase and an austenite phase that are mixed with each other. A chemical composition of the Cr-based two-phase alloy consists of a main component, an auxiliary component, impurities, a first optional auxiliary component, and a second optional auxiliary component. The main component consists of 33-61 mass % Cr, 18-40 mass % Ni and 10-33 mass % Fe, and a total content of the Ni and the Fe is 37-65 mass %. The auxiliary component consists of 0.1-2 mass % Mn, 0.1-1 mass % Si, 0.005-0.05 mass % Al, and 0.02-0.3 mass % Sn. The impurities include 0.04 mass % or less of P, 0.01 mass % or less of S, 0.03 mass % or less of C, 0.04 mass % or less of N, and 0.05 mass % or less of O.Type: GrantFiled: January 19, 2017Date of Patent: November 23, 2021Assignee: HITACHI, LTD.Inventors: Tomonori Kimura, Yasuhisa Aono, Makoto Ogata, Naoya Tokoo, Yasuo Kondo, Masafumi Noujima