Abstract: In an activity support device, a plan acquisition means acquires a target physical activity amount of a user in a predetermined period and a predictive physical activity amount representing an expected expenditure of a physical activity amount. An expended physical activity amount acquisition means acquires an expended physical activity amount of the user up to a current time in the predetermined period. A total expended physical activity amount acquisition means derives a total expended physical activity amount of the user in the predetermined period, based on the predictive physical activity amount and the expended physical amount. An activity determination means determines a physical activity to the user from among physical activity options by comparing the target physical amount and the total expended physical amount. Accordingly, it is possible for the activity support device to support a user in making a decision regarding the physical activity.

Abstract: The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl formate; Step (2): a step of mixing an amino acid or a peptide in which the N-terminal and the C-terminal are not protected with a trialkylsilylating agent; and Step (3): a step of mixing the product obtained in Step (1) with the product obtained in Step (2).

Abstract: A treatment method and medical device are disclosed for cutting a substance inside a body lumen. The medical device includes a drive shaft that is rotatable; a cutting unit configured to be rotatably connected to a distal side of the drive shaft; a filter device configured to be inserted in a contracted state, the filter device having an elongated shaft, which interlocks with a filter portion of the filter device; a distal tube, the distal tube being on a distal side of the cutting unit and configured to receive the elongated shaft of the filter device; and a housing on a proximal portion of the drive shaft, the housing including a first drive gear connected to the drive shaft, a second drive gear connected to a motor and meshing with the first drive gear, and a first partition wall arranged between the motor and the second drive gear.

Abstract: The present invention provides a compound represented by the following formula (I) or its pharmaceutically acceptable salt: [wherein, R1 represents optionally substituted C1-4 alkyl, n shows integer of 1 to 4, R2 represents optionally substituted C1-4 alkyl or hydrogen atom, R3 represents optionally substituted C1-4 alkyl, R4a, R4b, R4c, and R4d, similarly or differently, represent optionally substituted C6-14 aryl, optionally substituted C1-4 alkyl, or hydrogen atom and the like, A represents optionally substituted C6-14 aryl or optionally substituted 5 to 11 membered heteroaryl].

Abstract: The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R1a is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R1b is an optionally substituted C1-6 alkoxy, etc.; R1c is a hydrogen atom, an optionally substituted C1-6 alkoxy, etc.; R2 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, —(CH2)sO—, —(CH2)sN(R4)CO—, etc., B is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.), etc.; R4 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.

Abstract: Disclosed is a compound represented by the formula (1) below which has a high DPP-IV inhibitory activity and is improved in safety, toxicity and the like. Also disclosed is a prodrug of such a compound and pharmaceutically acceptable salts of them. (In the formula, R1 represents a hydrogen atom, an optionally substituted alkyl group or the like; R2 and R3 independently represent a hydrogen atom, an optionally substituted alkyl group or the like; R4 and R5 independently represent a hydrogen atom, an optionally substituted alkyl group or the like: R6 represents a hydrogen atom, an optionally substituted aryl group or the like; and —Y—NH2, represents a group represented by the following formula (A): (wherein m is 0, 1 or 2; and R7 may not exist or one or two R7 may exist and independently represent an optionally substituted alkyl group or the like) or the like.

Abstract: A compound represented by the following formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of either. These are compounds having high DPP-IV inhibitory activity and improved in safety, nontoxicity, etc. (I) [In the formula, R1 represents hydrogen, optionally substituted alkyl, etc.; the solid line and dotted line between A1 and A2 indicate a double bond (A1=A2), etc.; A1 represents a group represented by the formula C(R2), etc.; A2 represents a group represented by the formula C(R4), etc.; R2 represents hydrogen, optionally substituted alkyl, etc.; R4 represents hydrogen, optionally substituted alkyl, etc.; R6 represents hydrogen, optionally substituted aryl, etc.; and —Y represents, e.g.; a group represented by the formula (A): (A) (wherein m1 is 0, 1, 2, or 3; and R7 is absent, or one or two R7's are present and each independently represents optionally substituted alkyl, etc.).

Abstract: A photodegradable protective group comprising a benzyl group which is bound with a light capturing moiety that can absorb light of around 470 nm and having one or more nitro groups on the benzene ring.

Abstract: Electronic equipment includes two or more operating modes including a normal mode and a security mode and/or power saving mode. The electronic equipment comprises input devices which input information into the electronic equipment by a person performing an operation which is external to the electronic equipment, a sensor which is disposed in a rest portion of the input devices and which generates a predetermined signal in response to a detection that a part of the body of the person performing the operation rests on the rest portion, and a signal generator which generates a signal to instruct the electronic equipment not to shift to the security mode and/or power savings mode based on the predetermined signal generated by the sensor.