Patents by Inventor Tomowo Kobayashi
Tomowo Kobayashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6251915Abstract: A method for treatment or prevention of prostate cancer by administering an effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt or ester thereof. In formula (I) (which follows) , each of R1 and R2 is a hydrogen atom, a hydroxyl group, a protected hydroxyl group or a lower alkoxy group.Type: GrantFiled: June 8, 2000Date of Patent: June 26, 2001Assignee: Sankyo Company, LimitedInventors: Koichi Kojima, Tomowo Kobayashi
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Patent number: 6093722Abstract: A method for treatment or prevention of prostate cancer by administering an effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt or ester thereof. In formula (I) (which follows), each of R.sup.1 and R.sup.2 is a hydrogen atom, a hydroxyl group, a protected hydroxyl group or a lower alkoxy group.Type: GrantFiled: August 23, 1999Date of Patent: July 25, 2000Assignee: Sankyo Company, LimitedInventors: Koichi Kojima, Tomowo Kobayashi
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Patent number: 5792840Abstract: Compounds of formula (I): ##STR1## in which: R.sup.1 is hydroxy, protected hydroxy, fluorine, or --OP(O)(OH).sub.2 ; R.sup.2 and R.sup.3 are independently optionally substituted C.sub.6 -C.sub.20 aliphatic acyl; R.sup.4 is hydroxy, protected hydroxy, or --OP(O)(OH).sub.2, where at least one of R.sup.1 and R.sup.4 is --OP(O)(OH).sub.2 ; and R.sup.5 is hydroxy, protected hydroxy, or fluorine; provided that, except where at least one of R.sup.1 and R.sup.5 is fluorine, then at least one of R.sup.2 and R.sup.3 is a substituted C.sub.6 -C.sub.20 aliphatic acyl having (i) at least one halogen substituent and (ii) at least one substituent selected from the group consisting of halogen, hydroxy and C.sub.6 -C.sub.20 aliphatic acyloxy or at least one of R.sup.2 and R.sup.3 is a substituted C.sub.6 -C.sub.20 aliphatic acyl which is substituted by at least one halogen-substituted C.sub.6 -C.sub.Type: GrantFiled: July 26, 1994Date of Patent: August 11, 1998Assignee: Sankyo Company, LimitedInventors: Masao Shiozaki, Noboru Ishida, Masami Arai, Tetsuo Hiraoka, Tomowo Kobayashi, Yuzuru Akamatsu, Masahiro Nishijima
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Patent number: 5691319Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen atoms, optionally substituted alkanoyl groups and alkenylcarbonyl groups, PROVIDED THAT at least one of R.sup.1, R.sup.2 and R.sup.3 represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R.sup.4 and R.sup.5 represents a hydrogen atom and the other represents a cyano group; have valuable anti-tumor activity.Type: GrantFiled: June 5, 1995Date of Patent: November 25, 1997Assignee: Sankyo Company, LimitedInventors: Masakatsu Kaneko, Hitoshi Hotoda, Tomoyuki Shibata, Tomowo Kobayashi, Yoshihiro Mitsuhashi, Akira Matsuda, Takuma Sasaki
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Patent number: 5650430Abstract: Radicicol derivatives in which one or both hydroxy groups are acylated have valuable anti-tumor activity or may be used as chemical intermediates.Type: GrantFiled: June 7, 1995Date of Patent: July 22, 1997Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Kimio Iino, Yoshio Tsujita, Yoko Shimada, Tomowo Kobayashi, Takeshi Kagasaki
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Patent number: 5643908Abstract: Compounds having inhibitory activity against inhibitory activity against type IV collagenase and are useful as angiogenesis, cancer infiltration or cancer metastasis inhibitors. The compounds have the formula: ##STR1## in which R.sup.1 represents a group of formula: --OR.sup.3 (wherein R.sup.3 represents a hydrogen atom or an alkyl group),--NR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 each represents a hydrogen atom, an alkyl or alkoxy group),--NHCH(R.sup.6 COR.sup.7 (wherein R.sup.6 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, and R.sup.7 represents an alkyl group),--NHCH(R.sup.6)COOR.sup.8 (wherein R.sup.8 represents an alkyl group) or--NHCH(R.sup.6)CONR.sup.9 R.sup.10 (wherein R.sup.9 and R.sup.10 each represents a hydrogen atom or an alkyl group, or NR.sup.9 R.sup.10 together represent a heterocyclic ring group); andR.sup.2 represents a hydrogen atom, an alkyl or aralkyl group.Type: GrantFiled: June 27, 1994Date of Patent: July 1, 1997Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Kazuhiko Tamaki, Tomowo Kobayashi, Kazuhiko Tanzawa
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Patent number: 5633243Abstract: Compounds of formula (I): ##STR1## in which: A and B are separately monoamines or together diamines; and Z is a group of formula (II) or (III): ##STR2## (in which R.sup.1, R.sup.2 and R.sup.7 are various organic groups, n is 0, 1 or 2 and X is a direct carbon-carbon bond or lower alkylene) show valuable anti-tumor activity and may be prepared by reacting an amine-platinum complex with a compound providing the group represented by Z.Type: GrantFiled: June 7, 1995Date of Patent: May 27, 1997Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Tomoyuki Shibata, Yukiko Kameyama, Kimio Iino, Shigeki Muramatsu, Tomowo Kobayashi, Toshihiko Hashimoto
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Patent number: 5597846Abstract: A compound of the formula ##STR1## in which: R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen atoms and groups of formula R.sup.3 --CO--, wherein R.sup.3 represents a group selected from the group consisting of unsubstituted alkyl groups having from 9 to 20 carbon atoms; substituted alkyl groups having from 10 to 20 carbon atoms; unsubstituted alkenyl groups having from 9 to 20 carbon atoms; substituted alkenyl group having from 10 to 20 carbon atoms; unsubstituted alkynyl groups having from 8 to 10 carbon atoms; and substituted alkynyl groups having from 8 to 10 carbon atoms wherein R.sup.1 and R.sup.2 are not both hydrogen atoms or acetyl groups. The compounds have antitumor activity.Type: GrantFiled: September 23, 1994Date of Patent: January 28, 1997Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Kimio Iino, Yoshio Tsujita, Yoko Shimada, Tomowo Kobayashi, Takeshi Kagasaki
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Patent number: 5527905Abstract: Compounds of formula (I): ##STR1## in which: A and B are separately monoamines or together diamines; and Z is a group of formula (II) or (III): ##STR2## (in which R.sup.1, R.sup.2 and R.sup.7 are various organic groups, n is 0, 1 or 2 and X is a direct carbon-carbon bond or lower alkylene) show valuable anti-tumor activity and may be prepared by reacting an amine-platinum complex with a compound providing the group represented by Z.Type: GrantFiled: November 18, 1994Date of Patent: June 18, 1996Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Tomoyuki Shibata, Yukiko Kameyama, Kimio Iino, Shigeki Muramatsu, Tomowo Kobayashi, Toshihiko Hashimoto
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Patent number: 5409912Abstract: A new compound, which we have named Leustroducsin H, has formula (I): ##STR1## and pharmaceutically acceptable salts thereof. This compound may be prepared by hydrolysis of naturally occurring Leustroducsins and the compound may be used for the treatment or prophylaxis of thrombocytopenia.Type: GrantFiled: April 8, 1994Date of Patent: April 25, 1995Assignee: Sankyo Company, LimitedInventors: Yukio Sugimura, Tomoyuki Shibata, Kazuhiko Tamaki, Shinwa Kurihara, Takafumi Kohama, Akio Shiraishi, Tomowo Kobayashi, Kazuhiko Sasagawa, Naomi Shimazaki
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Patent number: 5391564Abstract: Rhizoxin and rhizoxin-2-ene derivatives of formula (I): ##STR1## in which: n is 1 to 25: A is an extra bond or oxygen, X is oxygen, sulfur, nitrogen or carbonyl; and R is hydrogen, carboxylic acyl having from 1 to 25 carbon atoms, alkoxycarbonyl group having from 2 to 26 carbon atoms, phosphono, alkylphosphono group in which the alkyl part has from 1 to 25 carbon atoms, dialkylphosphono group in which each alkyl part has from 1 to 25 carbon atoms, alkyl group having from 1 to 25 carbon atoms, aralkyl, cycloalkyl, heterocyclic, alkylthio group in which the alkyl part has from 1 to 25 carbon atoms, aralkylthio, or heterocyclylthio, or when X represents a nitrogen atom, R is R.sup.1 and R.sup.2, where R.sup.1 and R.sup.2 are hydrogen, alkyl, acyl, alkoxycarbonyl, phosphono, alkylphosphono or dialkylphosphono have valuable anti-tumor activity. They may be prepared by acylation of rhizoxin or rhizoxin-2-ene.Type: GrantFiled: February 14, 1994Date of Patent: February 21, 1995Assignee: Sankyo Company, LimitedInventors: Masakatsu Kaneko, Makoto Kamokari, Tomowo Kobayashi, Kazuhiko Sasagawa
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Patent number: 5352689Abstract: Rhizoxin and rhizoxin-2-ene derivatives of formula ##STR1## in which: n is 1 to 25; A is an extra bond or oxygen, X is oxygen, sulfur, nitrogen or carbonyl; and R is hydrogen, carboxylic acyl having from 1 to 25 carbon atoms, alkoxycarbonyl group having from 2 to 26 carbon atoms, phosphono, alkylphosphono group in which the alkyl part has from 1 to 25 carbon atoms, dialkylphosphono group in which each alkyl part has from 1 to 25 carbon atoms, alkyl group having from 1 to 25 carbon atoms, aralkyl, cycloalkyl, heterocyclic, alkylthio group in which the alkyl part has from 1 to 25 carbon atoms, aralkylthio, or heterocyclylthio, or when X represents a nitrogen atom, R is R.sup.1 and R.sup.2, where R.sup.1 and R.sup.2 are hydrogen, alkyl, acyl, alkoxycarbonyl, phosphono, alkylphosphono or dialkylphosphono, have valuable anti-tumor activity. They may be prepared by acylation of rhizoxin or rhizoxin-2-ene.Type: GrantFiled: September 27, 1993Date of Patent: October 4, 1994Assignee: Sankyo Company, LimitedInventors: Masakatsu Kaneko, Makoto Kamokari, Tomowo Kobayashi, Kazuhiko Sasagawa
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Patent number: 4520162Abstract: The novel polymeric compound proposed in the invention has a backbone structure formed of a copolymeric moiety of maleic anhydride and divinyl ether and pendant groups thereon derived from an anthracycline-type anti-tumor agent, e.g. adriamycin and daunomycin, or 1-.beta.-D-arabinofuranosylcytosine bonded to the maleic anhydride units in the backbone structure by forming amide linkages, the remaining anhydride units in the backbone structure being hydrolyzed into free acid form or a salt thereof. Both in vitro and in vivo tests indicate that the anti-tumor active pendant groups in the polymeric compound can be released sustainedly to exhibit the anti-tumor activity with greatly decreased side effects unavoidable when the above mentioned anti-tumor agents as such are administrated to a patient in a relatively large dose.Type: GrantFiled: September 17, 1984Date of Patent: May 28, 1985Assignee: Director-General of the Agency of Industrial Science & TechnologyInventors: Takashi Hirano, Shinichi Ohashi, Satoshi Morimoto, Masaru Shiraki, Keishiro Tsuda, Tomowo Kobayashi, Shigeru Tsukagoshi