Abstract: Although compounds for treating or ameliorating malignant diseases have been proposed, patients had to endure a large burden since many of such compounds could not be orally ingested. Mangiferin has an effect of ameliorating malignant diseases through oral ingestion. However, such effect is minor and realistically it was not easy to ingest mangiferin. Further, in order to develop more effective pharmaceutical agents and the like for treating malignant diseases, it has been considered constantly necessary to obtain new or improved forms of an existing medical agent for inhibiting kinases such as NIK. Compounds represented by formula (1), formula (2), formula (3), formula (4), formula (5), formula (6), formula (7), formula (8), formula (9), formula (10), formula (11), and formula (12) have an effect of ameliorating malignant diseases through oral ingestion, and can exhibit said effect with an amount less than that for mangiferin.

Abstract: [Problem] COVID-19 caused by coronavirus SARS-CoV-2, cytokine release syndrome, cytokine release syndrome with CAR (chimeric antigen receptor)-T therapy, sepsis, systemic inflammatory response syndrome, hemophagocytic syndrome, macrophage activation syndrome, influenza, GVHD, systemic vasculitis, Kawasaki disease, Takayasu arteritis, and other diseases, if severe, can cause acute respiratory distress syndrome, disseminated intravascular coagulation syndrome, acute circulatory insufficiency, multi-organ failure, and other symptoms which are one of the causes of death. [Solution to Problem] Compounds represented by formulas (1) to (4) are effective when taken orally and can be expressed in smaller amounts than mangiferin.

Abstract: An electronic musical instrument is configured to: (a) acquire input data that includes habit data indicative of a playing habit of a user in playing a musical instrument; (b) generate correction data by inputting the acquired input data into at least one trained model that learns a relationship between training input data and training correction data; and (c) correct, using the generated correction data, at least one first intensity characteristic representative of a relationship between: (i) a playing intensity in playing the musical instrument by the user; and (ii) a sound intensity of a musical sound output in response to playing of the musical instrument.

Abstract: After reading a predetermined number of predetermined blocks for each of a plurality of image data, a first image read unit 13 reads out the plurality of image data read in parallel by repeatedly switching the designated order of the plurality of image data. A JPEG compression unit 14 performs image compression on the plurality of image data read out in block units by the first image read unit 13, image-compresses a predetermined number of the blocks for each of the plurality of image data, and then inserts an identifier after the last block of the predetermined number of blocks.

Abstract: After reading a predetermined number of predetermined blocks for each of a plurality of image data, a first image read unit 13 reads out the plurality of image data read in parallel by repeatedly switching the designated order of the plurality of image data. A JPEG compression unit 14 performs image compression on the plurality of image data read out in block units by the first image read unit 13, image-compresses a predetermined number of the blocks for each of the plurality of image data, and then inserts an identifier after the last block of the predetermined number of blocks.