Abstract: The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.

Abstract: An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them.

Abstract: The present invention to provide a novel pyruvate dehydrogenase kinase inhibitors. A pyruvate dehydrogenase kinase inhibitor comprising a compound represented by the general formula (I) as an active ingredient (wherein, ring A represents a 6-membered aromatic hydrocarbon ring optionally substituted with 2-4 substituents, R1 and R4, which are the same or different, represent a hydrogen atom, a hydroxyl group, an optionally substituted C1-6 alkyl group, R2 and R3, which are the same or different, represent a hydrogen atom, a carboxyl group, an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group, or a group represented by —C (?R9)—R10), a pharmaceutical composition for treatment or prophylaxis of diseases or disorders that pyruvate dehydrogenase kinase relates to its development or aggravation, and a cosmetic composition, and the like.

Abstract: An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them.

Abstract: Novel macrolactone compounds, their methods of preparation, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the macrolactone compounds may be useful, inter alia, for treating various cancers, inducing apoptosis in malignant cells, or inhibiting cancer cell division.

Abstract: Novel macrolactone compounds, their methods of preparation, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the macrolactone compounds may be useful, inter alia, for treating various cancers, inducing apoptosis in malignant cells, or inhibiting cancer cell division.

Abstract: Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.

Abstract: Novel macrolactone compounds, their methods of preparation, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the macrolactone compounds may be useful, inter alia, for treating various cancers, inducing apoptosis in malignant cells, or inhibiting cancer cell division.

Abstract: Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.

Abstract: A two-opposed-main-shaft type composite NC lathe provided with a tool changeable tool spindle and tool turrets, comprising: a left turret rest and a right turret rest provided on a lower front side of a left main shaft and a right main shaft facing each other on a Z-axis; a third tool rest positioned on an upper rear side of the left and right main shafts and provided with a tool spindle; a tool magazine holding tools therein which are to be fixed to the third tool rest; and an automatic tool changing device. The left and right main shafts are provided with main shaft motors capable of controlling a C-axis and being driven independently and synchronously with each other. The tool spindle on the third tool rest is capable of controlling the directions of the Z-axis, an X-axis, a Y-axis and a B-axis and fixing the rotations thereof.

Abstract: A two-opposed-main-shaft type composite NC lathe provided with a tool changeable tool spindle and tool turrets, comprising: a left turret rest and a right turret rest provided on a lower front side of a left main shaft and a right main shaft facing each other on a Z-axis; a third tool rest positioned on an upper rear side of the left and right main shafts and provided with a tool spindle; a tool magazine holding tools therein which are to be fixed to the third tool rest; and an automatic tool changing device. The left and right main shafts are provided with main shaft motors capable of controlling a C-axis and being driven independently and synchronously with each other. The tool spindle on the third tool rest is capable of controlling the directions of the Z-axis, an X-axis, a Y-axis and a B-axis and fixing the rotations thereof.