Abstract: Antigen-binding domains that are capable of binding to CD3 and CD137 but do not bind to CD3 and CD137 at the same time and methods of using the same are provided. Methods to obtain antigen binding domains which bind to two or more different antigen more efficiently are also provided.

Abstract: The reverse input cutoff clutch includes: a pressed member having a pressed surface around the inner peripheral surface; an input member coaxially arranged with the pressed surface and having an input-side engaging portion arranged on the radially inner side of the pressed surface; an output member coaxially arranged with the pressed surface and having an output-side engaging portion arranged further on the radially inner side than the input-side engaging portion; and an engaging element arranged so as to be movable in a first direction as a direction toward or away from the pressed surface on the radially inner side of the pressed surface. The engaging element has a main engaging element body having a pressing surface and a pivot-support shaft, and a link member. The link member has a first end portion pivotally linked to the pivot-support shaft, and a second end portion pivotally linked to the input-side engaging portion.

Abstract: A form measuring instrument includes: a contact tip configured to contact with a workpiece; a movement mechanism configured to cause relative movement of the contact tip with respect to the workpiece; a movement controlling unit configured to control the movement mechanism; a contact sensor configured to detect a contact amount of the contact tip with the workpiece and output a detection signal corresponding to the contact amount; and an abnormality determining unit configured to determine an abnormality of sensitivity of the contact sensor based on a change in the detection signal outputted from the contact sensor during an operation of the movement mechanism in which the contact tip is pressed against the workpiece.

Abstract: A measurement apparatus includes a sensor that measures a workpiece, a multi-axis robot that moves the sensor in a three-dimensional space, a position determination part that determines i) a plurality of measurement positions that are positions along a normal direction at each of a plurality of positions to be measured on the workpiece and ii) a direction of the sensor at each of the plurality of measurement positions on the basis of at least either design data or captured image data indicating the geometry of the workpiece, a moving control part that sequentially moves the sensor to the plurality of measurement positions by controlling the robot, and a measurement control part that outputs measured data indicating a result that the sensor measured at each of the plurality of measurement positions in association with the plurality of positions to be measured.

Abstract: A form measuring instrument includes: a contact tip configured to contact with a workpiece; a movement mechanism configured to cause relative movement of the contact tip with respect to the workpiece; a movement controlling unit configured to control the movement mechanism; a contact sensor configured to detect a contact amount of the contact tip with the workpiece and output a detection signal corresponding to the contact amount; and an abnormality determining unit configured to determine an abnormality of sensitivity of the contact sensor based on a change in the detection signal outputted from the contact sensor during an operation of the movement mechanism in which the contact tip is pressed against the workpiece.

Abstract: A holder of a tapered roller bearing is made of a resin, has a first gap between an axially inner end surface of a small-diameter-side annular part and small-diameter-side end surfaces of tapered rollers, has a second gap between an axially inner end surface of a large-diameter-side annular part and large-diameter-side end surfaces of the tapered rollers, and is provided to be capable of moving within a prescribed range along the axial direction. The surface of the axially inner end surface of the large-diameter-side annular part is rough, the large-diameter-side annular part is provided with one or more grooves which are oil-holding parts that hold the lubricating oil, and ends of the grooves are positioned to be capable of coming into contact with the tapered rollers.

Abstract: A reverse input blocking clutch has: a pressed member having a pressed surface; an input member having an input-side engaging portion; an output member having an output-side engaging portion; and an engaging element having an engaging element main body and a link member to move in the first direction away from or toward the pressed surface. The engaging element main body has a pair of main body plates arranged to overlap in the axial direction, and a pivot support shaft arranged on the side in the first direction closer to the pressed surface than the input-side engaging portion with the both side portions supported by the pair of main body plates. One pressing surface facing the pressed surface is provided on one main body plate, and the other pressing surface is provided on the other main body plate.

Abstract: A reverse input blocking clutch has: a pressed member having a pressed surface; an input member having an input-side engaging portion; an output member having an output-side engaging portion; and an engaging element having an engaging element main body and a link member to move in the first direction away from or toward the pressed surface. The engaging element main body has a pair of main body plates arranged to overlap in the axial direction, and a pivot support shaft arranged on the side in the first direction closer to the pressed surface than the input-side engaging portion with the both side portions supported by the pair of main body plates. One pressing surface facing the pressed surface is provided on one main body plate, and the other pressing surface is provided on the other main body plate.

Abstract: A package including a container body containing a fluid with leaving a head space, wherein a container body (1) has an inner surface coated with a lubricating liquid (30) immiscible with a fluid (3), and the lubricating liquid (30) is present as a coating layer interposed between the inner surface and the fluid (3), the lubricating liquid (30) forms a liquid pool at a periphery of an upper end face of the fluid (3) contained in the container body (1) in a state of being held upright, and a contact angle of the lubricating liquid (30) to the inner surface is smaller than the contact angle of the fluid (3) to the inner surface.

Abstract: Provided is a container processing system capable of improving a speed of processing containers with a simple configuration and providing a compact production line. The container processing system (10) includes a container conveyer (20) having a container conveying path (21a) that conveys containers (C) arranged in a row and a container processor (40) that performs processing on the containers (C) in a container processing area (A2) set lateral to a container transfer area (A1) set in a segment of the container conveying path (21a). The container conveyer (40) includes a container carrier (21) conveying the containers (C) arranged in the row along the container conveying path (21a) and a container transferrer (22) moving a container row including the plurality of containers (C) arranged in the row in the container transfer area (A1) toward the container processing area (A2).

Abstract: Provided is a container processing system that inhibits, a processing liquid that is used to process containers from being attached to peripheral equipment. A container processing system (10) includes a chamber (30) having in an inside thereof a gas flow control chamber (35) and a container processor (40) including container treaters (51) and (61) that perform processing on containers (C). The chamber (30) has container processing openings (36) and (37) making the gas flow control chamber (35) and an outside of the chamber (30) communicate with each other. The container treaters (51) and (61) are configured to perform, from inside the gas flow control chamber (35), processing on the containers (C), which are inserted into the chamber (30) through the container processing openings (36) and (37), or on the containers (C), which is opposed to the container processing openings (36) and (37), outside the chamber (30).

Abstract: A holder of a tapered roller bearing is made of a resin, has a first gap between an axially inner end surface of a small-diameter-side annular part and small-diameter-side end surfaces of tapered rollers, has a second gap between an axially inner end surface of a large-diameter-side annular part and large-diameter-side end surfaces of the tapered rollers, and is provided to be capable of moving within a prescribed range along the axial direction. The surface of the axially inner end surface of the large-diameter-side annular part is rough, the large-diameter-side annular part is provided with one or more grooves which are oil-holding parts that hold the lubricating oil, and ends of the grooves are positioned to be capable of coming into contact with the tapered rollers.

Abstract: A package including a container body (1) containing a fluid content (3) with leaving a head space (7), wherein the container body (1) has an inner surface (1a) on which ruggedness is formed entirely, the inner surface (1a) with the ruggedness of the container body (1) is coated with a lubricating liquid (30) immiscible with the fluid content (3), and the lubricating liquid (30) is present as a coating layer interposed between the inner surface (1a) and the fluid content (3), and the lubricating liquid (30) for forming the coating layer forms a liquid pool (31) at a periphery of an upper end face of the fluid content (3) contained in the container body (1) in a state of being held upright.

Abstract: This imaging method of AMPA receptors in the brain of primate organisms involves a step in which a substance which is administered to the primate organism and which selectively bonds to AMPA receptors in the brain of the primate organism and has a radiolabel is transported into the brain and made to bond with AMPA receptors in the brain, and, by detecting radiation emitted from the substance bonded to the AMPA receptors in the brain, data is obtained relating to the distribution and/or expression level of the AMPA receptors in the brain.

Abstract: A package including a container body (1) containing a fluid content (3) with leaving a head space (7), wherein the container body (1) has an inner surface (1a) on which ruggedness is formed entirely, the inner surface (1a) with the ruggedness of the container body (1) is coated with a lubricating liquid (30) immiscible with the fluid content (3), and the lubricating liquid (30) is present as a coating layer interposed between the inner surface (1a) and the fluid content (3), and the lubricating liquid (30) for forming the coating layer forms a liquid pool (31) at a periphery of an upper end face of the fluid content (3) contained in the container body (1) in a state of being held upright.

Abstract: A structure forming a gel-like coating (3) on a surface of a base material (1) that is formed in a predetermined shape, the gel-like coating including fine solid particles of a grain size of not more than 50 ?m and an oily liquid.

Abstract: A structure including a formed body (1) and solid particles (3) distributed on a surface of the formed body (1) by being externally added thereto, wherein the solid particles (3) are held on the surface of the formed body (1) in a form of being covered with a very small amount of an oily liquid (5), and an air layer (7) is present in gaps among the solid particles (3) that are close to the surface of the formed body (1).

Abstract: Provided is a small capacity container for viscous substance, which is capable of quickly discharging a viscous content at any time even when being held upside down or almost upside down. In the small capacity container of not more than 300 ml to contain a viscous substance, a region for quickly discharging the content and a region for slowly discharging the content during the container is held upside down are formed on the inner surface of the barrel portion of the container.

Abstract: A coating material is uniformly applied on an inner wall surface of a container while preventing leakage of the coating material and an increase in an installation space. An application apparatus (10) that applies a coating material (L) on an inner wall surface of a container (C) includes: a spray gun (20) having a spray nozzle (22); an outgoing pipe (30) and a return pipe (33); a supply controller (50); a rotary driver (60); and a mover (70), wherein the outgoing pipe (30) and the return pipe (33) are each provided with a resilient-shape part (32, 35) capable of extending and contracting resiliently.

Abstract: A measuring head includes a first slide mechanism for a first measurement axis provided to be detachable to external moving devices; a second slide mechanism for a second measurement axis held to be movable by the first slide mechanism; a third slide mechanism for a third measurement axis held to be movable by the second slide mechanism; a probe held to be movable by the third slide mechanism; pneumatic cylinders for connecting slider parts and guide parts included in each slide mechanism; and automatic pressure regulators for respectively changing air pressures supplied to each pneumatic cylinder in accordance with measurement postures of the measuring head.