Abstract: Antigen-binding domains that are capable of binding to CD3 and CD137 but do not bind to CD3 and CD137 at the same time and methods of using the same are provided. Methods to obtain antigen binding domains which bind to two or more different antigen more efficiently are also provided.

Abstract: A force detector includes a low load cell, a high load cell, a first presser and a second presser. The first presser and the second presser have pressing surfaces having different areas from each other. When the same force acts on the first presser and the second presser, the low load cell and the high load cell are configured so that their outputs indicate different values from each other.

Abstract: A vehicle operation device (13) for enabling a vehicle operator to operate a vehicle (1), includes a switch unit (17) provided at a side of a vehicle operator's seat (21), and configured to accept an input operation for automatic drive of the vehicle. A first switch included in the switch unit (42) and configured to produce a signal relating to a control action for vehicle travel is provided with an inadvertent operation prevention feature configured to prevent an unintended contact to the first switch.

Abstract: The gun-shaped controller comprises a controller 1 in the shape of a gun and a trigger lever 7, and a cross-shaped directional key 9 to be operated with a player's finger is arranged in the upper part of a grip 4. By comprising the cross-shaped directional key 9, it is possible to move the character on the screen or the character's visual field with this cross-shaped directional key 9 in addition to the conventional action of shooting targets on the screen. Thus, the gun-shaped controller is compatible with roll-playing games and adventure games.

Abstract: A filter element comprising porous hollow fiber filter membranes arranged in a lengthwise direction and fusion-bonded together at one or both of their respective end portions to form a unified terminal block which has through-holes communicating with the hollows of the remaining unbonded portions of the membranes and having diameters substantially the same as the inner diameters of the membranes. The filter element not only is excellent in resistance to heat and chemicals, but also can realize an efficient filtration.

Abstract: A filter element comprising porous hollow fiber filter membranes arranged in a lengthwise direction and fusion-bonded together at one or both of their respective end portions to form a unified terminal block which has through-holes communicating with the hollows of the remaining unbonded portions of the membranes and having diameters substantially the same as the inner diameters of the membranes. The filter element not only is excellent in resistance to heat and chemicals, but also can realize an efficient filtration.