Abstract: An evaluating method includes an evaluating step of evaluating a pharmacological action of an immune checkpoint inhibitor in a subject to be evaluated, using (i) a concentration value of at least one metabolite among Glu, Arg, Orn, Cit, His, Val, Phe, Tyr, Met, Pro, Asn, Leu, Lys, Thr, Ile, Gln, Ala, Ser, a-ABA, Trp, Gly, AnthA, hAnthA, hIAA, hKyn, hTrp, IAA, ILA, Kyn, KynA, NFKyn, NP, PA, QA, Serot, and XA in blood of the subject to be evaluated, or (ii) a value of a formula calculated using the concentration value and the formula including an explanatory variable to be substituted with the concentration value.

Abstract: A pharmaceutical composition containing a heterocyclic compound of the formula (I) wherein each symbol is as defined in the specification, an isomer thereof, a solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient has a superior TNF-? production suppressing action. Accordingly, it is useful for the prophylaxis or treatment of various diseases caused by abnormal production of TNF-?.

Abstract: An inexpensive fuel supply device having a high output is achieved using low-output fuel pumps. First and second pumps, which are two inexpensive pumps having a low output, are disposed on a common mounting seat an inlet of each of the fuel pumps approaches a common fuel filter, discharge ports are connected to a common discharge passage so that the amount of fuel corresponding to the sum of the amounts of discharged fuel of the fuel pumps can be supplied from the common discharge passage, a common pressure regulator is connected to the common discharge passage, and the entire structure is formed as a unit, thereby obtaining an inexpensive pump unit having a high output.

Abstract: The present invention discloses a therapeutic agent for inflammatory bowel disease, which is in the from of delivering 1 to 5 g of glutamine to the large intestine per one administration; and the therapeutic agent for inflammatory bowel disease with which an anti-inflammatory agent(s) is combined. This therapeutic agent for inflammatory bowel disease can safely and effectively treat inflammatory bowel disease including ulcerative colitis without increasing the frequency of bowel movements.

Abstract: To provide a fuel pump mounting structural body that allows a mounting space for a fuel tank and the number of manufacturing processes to be reduced. A fuel pump mounting structural body accommodates a fuel pump unit in an opening portion disposed in a fuel tank. The structural body includes a step portion disposed in the opening portion. The step portion is formed one step lower than a wall surface of the fuel tank. A lid portion of the fuel pump unit is fittingly attached to the step portion and includes a delivery port for fuel. A guide member is disposed on a peripheral edge of the opening portion. The guide member includes a removably mounted holding member. The fuel pump unit is held in position by the fuel pump mounting structural body.

Abstract: The present invention discloses a therapeutic agent for inflammatory bowel disease, which is in the from of delivering 1 to 5 g of glutamine to the large intestine per one administration; and the therapeutic agent for inflammatory bowel disease with which an anti-inflammatory agent(s) is combined. This therapeutic agent for inflammatory bowel disease can safely and effectively treat inflammatory bowel disease including ulcerative colitis without increasing the frequency of bowel movements.

Abstract: The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituent(s), Y1 and Y2 are nitrogen atoms etc., an isomer or solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract: To provide a fuel pump mounting structural body that allows a mounting space for a fuel tank and the number of manufacturing processes to be reduced. A fuel pump mounting structural body accommodates a fuel pump unit in an opening portion disposed in a fuel tank. The structural body includes a step portion disposed in the opening portion. The step portion is formed one step lower than a wall surface of the fuel tank. A lid portion of the fuel pump unitis fittingly attached to the step portion and includes a delivery port for fuel. A guide member is disposed on a peripheral edge of the opening portion. The guide member includes a removably mounted holding member. The fuel pump unit is held in position by the fuel pump mounting structural body.

Abstract: The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituent(s), Y1 and Y2 are nitrogen atoms etc., an isomer or solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract: A pharmaceutical composition containing a heterocyclic compound of the formula (I) 1

Abstract: A semiconductor memory device of the type with a plurality of bit line pairs and signal lines disposed parallel to these bit line pairs is characterized in that two bit lines forming a pair are crossed at least once in the middle to prevent capacitance imbalance caused by misalignment of the associated signal line.

Abstract: In a semicondutor IC device such as a memory device with circuits to be selected and circuits to select one of these circuits to be selected in response to an input signal, each circuit to be selected is divided into parts but a fuse is provided corresponding to each of the parts such that each of the defective parts can be replaced by redundancy circuit without invalidating the other parts of the same circuit that is replaced.

Abstract: A motorcycle body frame structure made of an aluminum-based alloy, and suitable for off-road jumping and landing due to its increased rigidity and toughness, and the large stroke of its shock absorber. Maintenance is facilitated because the upper frame member is detachable from the head pipe and from the coupling member connecting the rear portions of the upper and lower frame members. The strength of the engine hanger is enhanced by securing it to a member connecting the front and rear frame portions. A large-size fuel tank is accommodated in a space defined between the upper frame member and left and right lower frame members.

Abstract: A semiconductor device such as a DRAM with many signal line circuits is also provided with a redundancy circuit and is so structured that when one of the signal line circuits is defective and the fuse contained by such a defective signal line circuit is cut off to inactivate it, an input signal which would select the inactivated signal line circuit will automatically select the redundancy circuit.

Abstract: A damper is interposed between a body of a vehicle and a wheel support arm adapted to support a wheel and mounted swingingly on the body, and a control device is operatively connected to a damping force generating device mounted to the damper for controlling the increase and decrease of a damping force of the damping force generating device in response to the swing motion of the wheel support arm. Therby a more effective damping function is exhibited to improve a riding comfort.

Abstract: A motorcycle includes a fuel tank mounted on a frame along a length thereof, and an elongated seat mounted on the frame above the fuel tank along the length of said frame, the seat having a bottom having a portion extending along the length thereof and disposed in spaced opposed relation to an upper surface of the fuel tank to form an air intake passageway therebetween. The passageway has an open front end opening toward the front end of the frame and having a rear open end. The seat has a front end disposed near a front end of the fuel tank so that the seat covers generally the entire upper surface of the fuel tank. An air cleaner is operatively connected to an engine and is disposed rearwardly of the fuel tank. The rear open end of the passageway is in communication with the air cleaner whereby the ambient air can be fed to the air cleaner through the air intake passageway.

Abstract: There is disclosed a frame-rear suspension assembly for a motorcycle and the like which comprises a frame including right and left tubular members, a rear fork pivotally connected to the right and left tubular members and a cross member made of a light alloy and provided between the right and left tubular members, and a rear-suspension system including a spring-loaded damper with one end pivotally connected to the frame, and link means for connecting the other end of the spring-loaded damper to the rear fork. The cross member is detachably connected between the right and left tubular members and the link means is connected to the cross member.

Abstract: An air intake system in a motorized cycle of the type wherein a fuel tank is disposed behind a top bridge. Within the fuel tank is formed an outside air introducing path having an opening formed in the front portion of the tank, with an air cleaner being disposed downstream of the outside air introducing path. With such arrangement, a relatively large flow of air can be introduced with a relatively small load on the air cleaner.

Abstract: A motorcycle includes a fuel tank mounted on a frame along a length thereof, and an elongated seat mounted on the frame above the fuel tank along the length of said frame, the seat having a bottom having a portion extending along the length thereof and disposed in spaced opposed relation to an upper surface of the fuel tank to form an air intake passageway therebetween. The passageway has an open front end opening toward the front end of the frame and having a rear open end. The seat has a front end disposed near a front end of the fuel tank so that the seat covers generally the entire upper surface of the fuel tank. An air cleaner is operatively connected to an engine and is disposed rearwardly of the fuel tank. The rear open end of the passageway is in communication with the air cleaner whereby the ambient air can be fed to the air cleaner through the air intake passageway.

Abstract: A motorcycle includes a fuel tank mounted on a frame along a length thereof, and an elongated seat mounted on the frame above the fuel tank along the length of said frame, the seat having a bottom having a portion extending along the length thereof and disposed in spaced opposed relation to an upper surface of the fuel tank to form an air intake passageway therebetween. The passageway has an open front end opening toward the front end of the frame and having a rear open end. The seat has a front end disposed near a front end of the fuel tank so that the seat covers generally the entire upper surface of the fuel tank. An air cleaner is operatively connected to an engine and is disposed rearwardly of the fuel tank. The rear open end of the passageway is in communication with the air cleaner whereby the ambient air can be fed to the air cleaner through the air intake passageway.