Patents by Inventor Tomozumi NODA

Tomozumi NODA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10829710
    Abstract: Provided is a lubricity-imparting agent that can impart durable lubricity (in particular, lubricity at the time of wetting) to a substrate. It has been found that a lubricity-imparting agent including a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (B) based on a photoreactive functional group-containing monomer, or a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine, a constitutional unit (B) based on a photoreactive functional group-containing monomer, and a constitutional unit (C) based on a hydrophobic group-containing monomer can impart durable lubricity to a substrate surface through a simple approach called photoirradiation.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: November 10, 2020
    Assignees: NOF CORPORATION, THE UNIVERSITY OF TOKYO
    Inventors: Kazuhiko Ishihara, Tomozumi Noda, Masaru Matsuda, Satoshi Yamada, Nobuyuki Sakamoto
  • Publication number: 20200271642
    Abstract: A compound is provided which is effectively adsorbed to a substrate surface, such as an immune reaction vessel, has extremely high protein adsorption inhibitory effect that inhibits non-specific adsorption of protein or the like, and has excellent washability to retain the inhibitory effect before and after washing operation of the substrate. Also provided are a protein adsorption inhibitor using the compound, a phosphorylcholine-modified substrate, and a method for inhibiting protein adsorption. The compound is a phosphorylcholine group-containing polyethylene glycol derivative represented by formula (1). The method for inhibiting protein adsorption of the present invention includes the step of forming an adsorbed layer of the derivative on a substrate surface.
    Type: Application
    Filed: August 28, 2018
    Publication date: August 27, 2020
    Inventors: Akane Katori, Masaru Matsuda, Tomozumi Noda, Takashi Sasaki, Hirotaka Suzuki, Nobuyuki Sakamoto
  • Patent number: 10620177
    Abstract: A protein adsorption inhibitor includes a compound of Formula (1) as an active ingredient. The protein adsorption inhibitor is capable of highly inhibiting non-specific adsorption of a protein such as an antibody or an enzyme to a surface of a base body such as an immune reaction vessel or an assay instrument. Also provided is a coating layer-formed base body having a coating layer containing the protein adsorption inhibitor on the base body. The coating layer-formed base body has an excellent protein adsorption-inhibiting function. A method for inhibiting the adsorption of the protein to the base body is provided. The method includes forming the coating layer containing the protein adsorption inhibitor on the surface of the base body: wherein, X is a hydrogen atom or a methyl group and n is an integer of 9 to 15.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: April 14, 2020
    Assignee: NOF CORPORATION
    Inventors: Fumio Nakashima, Satoshi Yamada, Tomozumi Noda, Masaru Matsuda
  • Publication number: 20200025750
    Abstract: A coating agent for preventing the adsorption of extracellular vesicles represented by exosomes to a tool has been developed. Adsorption of extracellular vesicles to a tool can be prevented by using a coating agent which contains a hydrophilic polymer having a weight average molecular weight of 10,000 or more and 1,000,000 or less, wherein a coated layer formed by the coating agent has a contact angle of 0 degree or more and 30 degrees or less.
    Type: Application
    Filed: May 23, 2017
    Publication date: January 23, 2020
    Inventors: Kiyotaka Shiba, Nobuyuki Sakamoto, Tomozumi Noda, Satoshi Yamada
  • Patent number: 10494595
    Abstract: An object is to provide a method of manufacturing a vessel for embryoid body formation excellent in formability of an embryoid body and suitable for optical observation.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: December 3, 2019
    Assignee: NOF CORPORATION
    Inventors: Tomozumi Noda, Fumio Nakashima, Satoshi Yamada, Nobuyuki Sakamoto
  • Publication number: 20190316054
    Abstract: Provided is a lubricity-imparting agent that can impart durable lubricity (in particular, lubricity at the time of wetting) to a substrate. It has been found that a lubricity-imparting agent including a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine and a constitutional unit (B) based on a photoreactive functional group-containing monomer, or a copolymer containing a constitutional unit (A) based on 2-methacryloyloxyethyl phosphorylcholine, a constitutional unit (B) based on a photoreactive functional group-containing monomer, and a constitutional unit (C) based on a hydrophobic group-containing monomer can impart durable lubricity to a substrate surface through a simple approach called photoirradiation.
    Type: Application
    Filed: June 28, 2017
    Publication date: October 17, 2019
    Applicants: NOF CORPORATION, THE UNIVERSITY OF TOKYO
    Inventors: Kazuhiko ISHIHARA, Tomozumi NODA, Masaru MATSUDA, Satoshi YAMADA, Nobuyuki SAKAMOTO
  • Patent number: 10323132
    Abstract: Provided are a copolymer having enough biocompatibility to be used in a medical material application, and a method of forming a crosslinked body, which involves modifying a substrate surface with the copolymer so that the surface may be biocompatible. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that the object is achieved by a copolymer containing a phosphorylcholine constitutional unit, a hydrophobic constitutional unit, and a photoreactive constitutional unit at a specific ratio.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: June 18, 2019
    Assignees: NOF Corporation, The University of Tokyo
    Inventors: Kazuhiko Ishihara, Yuuki Inoue, Kyoko Fukazawa, Masaru Matsuda, Satoshi Yamada, Tomozumi Noda
  • Publication number: 20190153137
    Abstract: Provided are a copolymer having biocompatibility sufficient for use in medical material applications, and a method of forming a crosslinked body, the method including imparting biocompatibility to a substrate surface through the use of the copolymer. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that a copolymer containing a phosphorylcholine constitutional unit and a photoreactive constitutional unit, or a copolymer containing a phosphorylcholine constitutional unit, a photoreactive constitutional unit, and a hydrophobic constitutional unit can impart a protein adsorption-suppressing effect and a cell adhesion-suppressing effect to a substrate surface through a simple approach called photoirradiation.
    Type: Application
    Filed: June 28, 2017
    Publication date: May 23, 2019
    Applicants: NOF CORPORATION, THE UNIVERSITY OF TOKYO
    Inventors: Kazuhiko ISHIHARA, Masaru MATSUDA, Tomozumi NODA, Satoshi YAMADA, Nobuyuki SAKAMOTO
  • Publication number: 20180051140
    Abstract: Provided are a copolymer having enough biocompatibility to be used in a medical material application, and a method of forming a crosslinked body, which involves modifying a substrate surface with the copolymer so that the surface may be biocompatible. More specifically, a protein adsorption-suppressing effect and a cell adhesion-suppressing effect, which are features of a phosphorylcholine group, are imparted to the substrate surface. It has been found that the object is achieved by a copolymer containing a phosphorylcholine constitutional unit, a hydrophobic constitutional unit, and a photoreactive constitutional unit at a specific ratio.
    Type: Application
    Filed: March 2, 2016
    Publication date: February 22, 2018
    Applicants: THE UNIVERSITY OF TOKYO, NOF CORPORATION
    Inventors: Kazuhiko Ishihara, Yuuki Inoue, Kyoko Fukazawa, Masaru Matsuda, Satoshi Yamada, Tomozumi Noda
  • Patent number: 9879250
    Abstract: There is provided a protein stabilizer containing a compound represented by Formula (1) as an active ingredient. The protein stabilizer is capable of stabilizing a protein in a solution state for a long period of time without affecting an assay system, the protein being not limited to enzymes, labeling substances such as fluorescent substances and chemiluminescent substances, and assay target substances. There is also provided a protein stabilization method containing making the protein coexist with the compound represented by Formula (1) in a water-containing solution. In Formula (1), X is a hydrogen atom or a methyl group, and n is an integer of 3 to 17.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: January 30, 2018
    Assignee: NOF CORPORATION
    Inventors: Fumio Nakashima, Masaru Matsuda, Tomozumi Noda, Satoshi Yamada
  • Publication number: 20170335266
    Abstract: An object is to provide a method of manufacturing a vessel for embryoid body formation excellent in formability of an embryoid body and suitable for optical observation.
    Type: Application
    Filed: October 30, 2015
    Publication date: November 23, 2017
    Applicant: NOF CORPORATION
    Inventors: Tomozumi NODA, Fumio NAKASHIMA, Satoshi YAMADA, Nobuyuki SAKAMOTO
  • Publication number: 20170261481
    Abstract: A protein adsorption inhibitor includes a compound of Formula (1) as an active ingredient. The protein adsorption inhibitor is capable of highly inhibiting non-specific adsorption of a protein such as an antibody or an enzyme to a surface of a base body such as an immune reaction vessel or an assay instrument. Also provided is a coating layer-formed base body having a coating layer containing the protein adsorption inhibitor on the base body. The coating layer-formed base body has an excellent protein adsorption-inhibiting function. A method for inhibiting the adsorption of the protein to the base body is provided. The method includes forming the coating layer containing the protein adsorption inhibitor on the surface of the base body: wherein, X is a hydrogen atom or a methyl group and n is an integer of 9 to 15.
    Type: Application
    Filed: September 8, 2015
    Publication date: September 14, 2017
    Applicant: NOF CORPORATION
    Inventors: Fumio NAKASHIMA, Satoshi YAMADA, Tomozumi NODA, Masaru MATSUDA
  • Publication number: 20170226499
    Abstract: There is provided a protein stabilizer containing a compound represented by Formula (1) as an active ingredient. The protein stabilizer is capable of stabilizing a protein in a solution state for a long period of time without affecting an assay system, the protein being not limited to enzymes, labeling substances such as fluorescent substances and chemiluminescent substances, and assay target substances. There is also provided a protein stabilization method containing making the protein coexist with the compound represented by Formula (1) in a water-containing solution. In Formula (1), X is a hydrogen atom or a methyl group, and n is an integer of 3 to 17.
    Type: Application
    Filed: August 6, 2015
    Publication date: August 10, 2017
    Applicant: NOF CORPORATION
    Inventors: Fumio NAKASHIMA, Masaru MATSUDA, Tomozumi NODA, Satoshi YAMADA