Patents by Inventor Tomy Varghese

Tomy Varghese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and apparatus for rapid acquisition of elasticity data in three dimensions
    Patent number: 10488247
    Abstract: Interpolation of ultrasound data at regular grid locations is provided by simultaneously optimizing interpolated data according to fidelity of interpolation of the voxel data to actual measured spatial data and according to a gradient of the interpolated data. This process is made amenable to real-time processing by limiting the range of interpolation to produce a sparse interpolated matrix that may be readily inverted. Artifacts and inefficiencies from successive stages of interpolation and data smoothing are thereby avoided.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: November 26, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Tomy Varghese, Atul Nishikant Ingle
  • Method and apparatus for rapid acquisition of elasticity data in three dimensions
    Patent number: 9913624
    Abstract: High-speed three-dimensional reconstruction of elasticity data is obtained by acquiring a sparse set of data in planes sharing a common axis line and angularly arrayed about the axis line. The axis line may be an RF ablation probe and the reconstruction may enforce a circumferential smoothness in the reconstruction about the probe, as is compatible with an ablation volume.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: March 13, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Tomy Varghese, Atul Nishikant Ingle
  • Method and Apparatus for Rapid Acquisition of Elasticity Data in Three Dimensions
    Publication number: 20150330832
    Abstract: Interpolation of ultrasound data at regular grid locations is provided by simultaneously optimizing interpolated data according to fidelity of interpolation of the voxel data to actual measured spatial data and according to a gradient of the interpolated data. This process is made amenable to real-time processing by limiting the range of interpolation to produce a sparse interpolated matrix that may be readily inverted. Artifacts and inefficiencies from successive stages of interpolation and data smoothing are thereby avoided.
    Type: Application
    Filed: May 13, 2014
    Publication date: November 19, 2015
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Tomy Varghese, Atul Nishikant Ingle
  • Method and Apparatus for Rapid Acquisition of Elasticity Data in Three Dimensions
    Publication number: 20140243668
    Abstract: High-speed three-dimensional reconstruction of elasticity data is obtained by acquiring a sparse set of data in planes sharing a common axis line and angularly arrayed about the axis line. The axis line may be an RF ablation probe and the reconstruction may enforce a circumferential smoothness in the reconstruction about the probe, as is compatible with an ablation volume.
    Type: Application
    Filed: February 28, 2013
    Publication date: August 28, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Tomy Varghese, Atul Nishikant Ingle
  • Rapid two/three-dimensional sector strain imaging
    Patent number: 8403850
    Abstract: An elastographic imaging system providing for axial, lateral and elevational strain measurements employs a series of one-dimensional axial measurements to deduce a coarse axial, lateral and/or elevational displacement that is used to guide one or more, two- or three-dimensional cross-correlations of smaller kernels providing improved image resolution.
    Type: Grant
    Filed: March 25, 2008
    Date of Patent: March 26, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Tomy Varghese, Hao Chen
  • Method and apparatus for monitoring tissue ablation
    Patent number: 8328726
    Abstract: Real-time monitoring of tissue ablation is possible by using a vibrating ablation needle coupling lateral shear waves to the tissue. Ultrasonic imaging may characterize the velocity of these shear waves to reveal Young's modulus of the tissue and, at a discontinuity in Young's modulus, a boundary of the ablated lesion reflecting an underlying increase in stiffness of ablated tissue. This technique may be coupled with quasi-static elastography-based ablation monitoring techniques for improved measurement.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: December 11, 2012
    Inventors: Tomy Varghese, Shyam Bharat
  • METHOD AND APPARATUS FOR MONITORING TISSUE ABLATION
    Publication number: 20100256530
    Abstract: Real-time monitoring of tissue ablation is possible by using a vibrating ablation needle coupling lateral shear waves to the tissue. Ultrasonic imaging may characterize the velocity of these shear waves to reveal Young's modulus of the tissue and, at a discontinuity in Young's modulus, a boundary of the ablated lesion reflecting an underlying increase in stiffness of ablated tissue. This technique may be coupled with quasi-static elastography-based ablation monitoring techniques for improved measurement.
    Type: Application
    Filed: April 1, 2009
    Publication date: October 7, 2010
    Inventors: Tomy Varghese, Shyam Bharat
  • High resolution elastography using two step strain estimation
    Patent number: 7632230
    Abstract: High-resolution elastography employs a multiple-step process in which successively finer samplings of data and smaller areas of data are evaluated to provide increasingly accurate displacement measurements, wherein each displacement measurement guides the determination of corresponding regions of comparison used in the next displacement evaluation.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: December 15, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Tomy Varghese, Hairong Shi, Hao Chen
  • Ultrasonic elastography with angular compounding
    Patent number: 7601122
    Abstract: Ultrasonic strain measurements, which characterize the structure of tissue, may be obtained by combining multiple echo signals acquired at different compressions and at different angles. Such angular compounding may improve the quality of the elastic signal and provide at one time both an axial and lateral strain measurement.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: October 13, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James A. Zagzebski, Tomy Varghese
  • RAPID TWO/THREE-DIMENSIONAL SECTOR STRAIN IMAGING
    Publication number: 20090247871
    Abstract: An elastographic imaging system providing for axial, lateral and elevational strain measurements employs a series of one-dimensional axial measurements to deduce a coarse axial, lateral and/or elevational displacement that is used to guide one or more two or three-dimensional cross-correlations of smaller kernels providing improved image resolution.
    Type: Application
    Filed: March 25, 2008
    Publication date: October 1, 2009
    Inventors: Tomy Varghese, Hao Chen
  • CHARACTERIZATION OF VULNERABLE PLAQUE USING DYNAMIC ANALYSIS
    Publication number: 20090198129
    Abstract: Arterial plaques are evaluated by determining their deformation under the periodic pulsatile force of blood flow. A relationship between plaque deformation and rupture risk is established by measurement of a relationship between deformation and cognitive decline in a sample population. The measured parameters include the maximum accumulated axial strain, maximum lateral displacement and maximum shear strains in soft vulnerable plaques.
    Type: Application
    Filed: February 5, 2008
    Publication date: August 6, 2009
    Inventors: Tomy Varghese, Robert J. Dempsey, Bruce P. Hermann
  • Ultrasonic elastography providing axial, orthogonal, and shear strain
    Patent number: 7331926
    Abstract: Ultrasonic signals obtained at a range of angles are fit to a material independent model to derive both axial and lateral strain and thus parameters dependent on lateral strain including Poisson's ratio and shear strain.
    Type: Grant
    Filed: February 23, 2004
    Date of Patent: February 19, 2008
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Tomy Varghese, Udomchai Techavipoo, Quan Chen, James A. Zagzebski
  • Method and apparatus for imaging the cervix and uterine wall
    Patent number: 7297116
    Abstract: Elastography is used to examine soft tissue of the uterus to detect tumors and to evaluate the strength of the cervix of the uterus based on its elastographic properties.
    Type: Grant
    Filed: April 21, 2003
    Date of Patent: November 20, 2007
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Tomy Varghese, Mark Alan Kliewer, James A. Zagzebski
  • Parametric ultrasound imaging using angular compounding
    Patent number: 7275439
    Abstract: Parametric ultrasonic measurements which characterize the structure of tissue, using information from an ultrasonic signal beyond amplitude information, are obtained by combining multiple ultrasonic signals acquired at different angles, thereby reducing the variance of the calculations. Such angular compounding may be applied to detecting scatterer size, spacing, density, and attenuation.
    Type: Grant
    Filed: February 4, 2004
    Date of Patent: October 2, 2007
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James A. Zagzebski, Tomy Varghese, Anthony L. Gerig
  • High resolution elastography using two step strain estimation
    Publication number: 20070083113
    Abstract: High-resolution elastography employs a multiple-step process in which successively finer samplings of data and smaller areas of data are evaluated to provide increasingly accurate displacement measurements, wherein each displacement measurement guides the determination of corresponding regions of comparison used in the next displacement evaluation.
    Type: Application
    Filed: March 20, 2006
    Publication date: April 12, 2007
    Inventors: Tomy Varghese, Hairong Shi, Hao Chen
  • Elastographic imaging of in vivo soft tissue
    Patent number: 7166075
    Abstract: Elastographic images provide visualization in two or three dimensions of RF ablation lesions to guide in the ablation process. Compression may be applied using the RF probe. A similar technique may be applied to in vivo imaging of soft tissue without ablation.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: January 23, 2007
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Tomy Varghese, James A. Zagzebski, Udomchai Techavipoo, Quan Chen
  • Ultrasonic elastography providing axial, orthogonal, and shear strain
    Publication number: 20050165309
    Abstract: Ultrasonic signals obtained at a range of angles are fit to a material independent model to derive both axial and lateral strain and thus parameters dependent on lateral strain including Poisson's ratio and shear strain.
    Type: Application
    Filed: February 23, 2004
    Publication date: July 28, 2005
    Inventors: Tomy Varghese, Udomchai Techavipoo, Quan Chen, James Zagzebski
  • Parametric ultrasound imaging using angular compounding
    Publication number: 20040243001
    Abstract: Parametric ultrasonic measurements which characterize the structure of tissue, using information from an ultrasonic signal beyond amplitude information, are obtained by combining multiple ultrasonic signals acquired at different angles, thereby reducing the variance of the calculations. Such angular compounding may be applied to detecting scatterer size, spacing, density, and attenuation.
    Type: Application
    Filed: February 4, 2004
    Publication date: December 2, 2004
    Inventors: James A. Zagzebski, Tomy Varghese, Anthony L. Gerig
  • Ultrasonic elastography with angular compounding
    Publication number: 20040215075
    Abstract: Ultrasonic strain measurements, which characterize the structure of tissue, may be obtained by combining multiple echo signals acquired at different compressions and at different angles. Such angular compounding may improve the quality of the elastic signal and provide at one time both an axial and lateral strain measurement.
    Type: Application
    Filed: January 27, 2004
    Publication date: October 28, 2004
    Inventors: James A. Zagzebski, Tomy Varghese
  • Method and apparatus for imaging the cervix and uterine wall
    Publication number: 20040210136
    Abstract: Elastography is used to examine soft tissue of the uterus to detect tumors and to evaluate the strength of the cervix of the uterus based on its elastographic properties.
    Type: Application
    Filed: April 21, 2003
    Publication date: October 21, 2004
    Inventors: Tomy Varghese, Mark Alan Kliewer, James A. Zagzebski