Abstract: The present invention relates to a device (10) for determining an arterial compliance of a subject (12). The device (10) comprises an inflatable cuff (14), a pressure sensor (18) which is configured to sense a pressure signal (52) that is indicative of a pressure within the cuff (14), a second sensor (20) which is at least partly integrated in the cuff (14) and configured to sense a second signal (56) that is responsive to expansions and contractions of the cuff (14) caused by a pulsating blood flow in an artery (50) of the subject (12), and a processing unit (22). The processing unit is configured to determine based on said part of the pressure signal (52) a pulse pressure of the subject (12), to determine based on said part of the second signal (56) an arterial volume change of the artery (50) of the subject (12) during at least one cardiac cycle, and to determine the arterial compliance of the subject (12) based on pulse pressure and the arterial volume change.