Patents by Inventor Ton T. Hai

Ton T. Hai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYMERIC BENZYL CARBONATE-DERIVATIVES
    Publication number: 20100048483
    Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
    Type: Application
    Filed: August 21, 2009
    Publication date: February 25, 2010
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Guohan Yang, Ton T. Hai, Bennett Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
  • Oxirane-modified hemoglobin based composition
    Patent number: 5248766
    Abstract: A non-immunogenic mixture of hemoglobin based modified monomers and oligomers produced by the polymerization of a hemoglobin based solution in the presence of a three membered heterocyclic ring, i.e. polyether oxirane. The modified hemoglobin composition has a P.sub.50 of at least equivalent to the P.sub.50 of human red blood cell hemoglobin.
    Type: Grant
    Filed: April 21, 1992
    Date of Patent: September 28, 1993
    Assignee: Baxter International Inc.
    Inventors: Deanna J. Nelson, Ton T. Hai, Ana Srnak
  • Process for the production of crosslinked hemoglobin in the presence of sodium tripolyphosphate
    Patent number: 5128452
    Abstract: A process for the production of crosslinked hemoglobin comprises crosslinking hemoglobin in the presence of sodium tripolyphosphate.
    Type: Grant
    Filed: April 19, 1989
    Date of Patent: July 7, 1992
    Assignee: Baxter International Inc.
    Inventors: Ton T. Hai, Deanna J. Nelson, Ana Srnak
  • Preparation of bis(salicyl) diesters
    Patent number: 5041615
    Abstract: Bis(salicyl) diesters useful as cross-linking agents for hemoglobin are prepared in high yield and purity by reacting salicylic acid or a derivative thereof with a lower aliphatic dicarboxylic acid halide in a lower aliphatic ketone or nitrile solvent in the presence of a pyridine derivative. The desired diester is recovered from the resulting insoluble pyridine derivative salt.
    Type: Grant
    Filed: December 5, 1989
    Date of Patent: August 20, 1991
    Assignee: Baxter International Inc.
    Inventors: Ton T. Hai, Deanna J. Nelson, Ana Srnak
  • Pharmaceutical grade 3,5-dibromosalicylic acid and metohd for synthesizing same
    Patent number: 5013866
    Abstract: An improved method of synthesizing 3,5-dibromosalicylic acid provides a highly purified pharmaceutical grade product free of toxic by-products and solvents. The purified product may be utilized as an intermediate in synthesizing pharmaceutical grade substances, as a bactericide when incorporated into topical ointments, and as an adjuvant in drug absorption systems.
    Type: Grant
    Filed: November 28, 1989
    Date of Patent: May 7, 1991
    Assignee: Baxter International Inc.
    Inventors: Ton T. Hai, Deanna J. Nelson