Patents by Inventor Ton That Hai
Ton That Hai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140287016Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate.Type: ApplicationFiled: March 14, 2014Publication date: September 25, 2014Applicants: BAXTER INTERNATIONAL INC., NORTHWESTERN UNIVERSITY, BAXTER HEALTHCARE SAInventors: Ton That Hai, John-Bruce Devault Green, Timothy Michael Fulghum, Phillip Byron Messersmith, Tadas Stanislovas Sileika
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Publication number: 20140128445Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.Type: ApplicationFiled: January 13, 2014Publication date: May 8, 2014Applicants: Baxter Healthcare SA, Baxter International Inc.Inventors: Guohan Yang, Ton That Hai, Bennett Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
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Patent number: 8653131Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.Type: GrantFiled: August 21, 2009Date of Patent: February 18, 2014Assignees: Baxter Healthcare S.A., Baxter International Inc.Inventors: Guohan Yang, Ton That Hai, Bennett P. Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
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Publication number: 20140001112Abstract: Methods and devices for providing dialysis treatment are provided. The device comprises a cartridge for providing regenerative dialysis, the cartridge comprising: a body having an inlet and an outlet and defining an interior, the interior including at least a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon, wherein at least two of the layers are blended together to provide a gradient of the two materials.Type: ApplicationFiled: June 18, 2013Publication date: January 2, 2014Inventors: Sujatha Karoor, Brian Donovan, Ton That Hai, Mari Katada, Luis Lu, Leo Martis, Stavroula Morti, Salim Mujais, Paul J. Sanders, Paul J. Soltys, Rahul Tandon
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Patent number: 8491517Abstract: Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.Type: GrantFiled: October 26, 2011Date of Patent: July 23, 2013Assignee: Baxter International Inc.Inventors: Sujatha Karoor, Brian Donovan, Ton That Hai, Mari Katada, Luis Lu, Leo Martis, Stavroula Morti, Salim Mujais, Paul J. Sanders, Paul J. Soltys, Rahul Tandon
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Patent number: 8431086Abstract: A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.Type: GrantFiled: June 7, 2011Date of Patent: April 30, 2013Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Kent L. Lurvey, Shmuel Sternberg, Vadim V. Krongauz, Rosa H. Yeh, Robin G. Pauley, Dustin C. Cawthon, Ton That Hai, Lecon L. Woo, Ashok K. Khanna, Birendra K. Lal, Michael Tung-Kiung Ling, William S. Hoerle, Craig L. Sandford, Mark A. Nordhaus, Alexander Savitski, Nicklaus J. Kirichkow, Kenneth Glen Suh, Sivaramakrishnan Krishnamoorthy, Hsinjin E. Yang, Robert A. Clarke
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Publication number: 20120037558Abstract: Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.Type: ApplicationFiled: October 26, 2011Publication date: February 16, 2012Applicant: BAXTER INTERNATIONAL INC.Inventors: Sujatha Karoor, Brian Donovan, Ton That Hai, Mari Katada, Luis Lu, Leo Martis, Stavroula Morti, Salim Mujais, Paul J. Sanders, Paul J. Soltys, Rahul Tandon
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Patent number: 8066658Abstract: Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.Type: GrantFiled: May 13, 2009Date of Patent: November 29, 2011Assignee: Baxter International Inc.Inventors: Sujatha Karoor, Brian Donovan, Ton That Hai, Mari Katada, Luis Lu, Leo Martis, Stavroula Morti, Salim Mujais, Paul J. Sanders, Paul J. Soltys, Rahul Tandon
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Publication number: 20110236258Abstract: A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.Type: ApplicationFiled: June 7, 2011Publication date: September 29, 2011Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.Inventors: Kent L. Lurvey, Shmuel Sternberg, Vadim V. Krongauz, Rosa H. Yeh, Robin G. Pauley, Dustin C. Cawthon, Ton That Hai, Lecon L. Woo, Ashok K. Khanna, Birendra K. Lal, Michael Tung-Kiung Ling, William S. Hoerle, Craig L. Sandford, Mark A. Nordhaus, Alexander Savitski, Nicklaus J. Kirichkow, Kenneth Glen Suh, Sivaramakrishnan Krishnamoorthy, Hsinjin E. Yang, Robert A. Clarke
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Patent number: 8002726Abstract: Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.Type: GrantFiled: August 13, 2009Date of Patent: August 23, 2011Assignee: Baxter International Inc.Inventors: Sujatha Karoor, Brian Donovan, Ton That Hai, Mari Katada, Luis Lu, Leo Martis, Stavroula Morti, Salim Mujais, Paul J. Sanders, Paul J. Soltys, Rahul Tandon
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Patent number: 7981381Abstract: A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.Type: GrantFiled: July 20, 2007Date of Patent: July 19, 2011Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Kent L. Lurvey, Shmuel Sternberg, Vadim V. Krongauz, Rosa H. Yeh, Robin G. Pauley, Dustin C. Cawthon, Ton That Hai, Lecon L. Woo, Ashok K. Khanna, Birendra K. Lal, Michael Tung-Kiung Ling, William S. Hoerle, Craig L. Sandford, Mark A. Nordhaus, Alexander Savitski, Nicklaus J. Kirichkow, Kenneth Glen Suh, Sivaramakrishnan Krishnamoorthy, Hsinjin E. Yang, Robert A. Clarke
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Patent number: 7955290Abstract: Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.Type: GrantFiled: July 6, 2007Date of Patent: June 7, 2011Assignee: Baxter International Inc.Inventors: Sujatha Karoor, Brian Donovan, Ton That Hai, Mari Katada, Luis Lu, Leo Martis, Stavroula Morti, Salim Mujais, Paul J. Sanders, Paul J. Soltys, Rahul Tandon
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Patent number: 7776360Abstract: The present invention is directed to novel compounds, methods of manufacture and methods of use. The present invention is also directed to solid drug/active agent particles having one or more of the compounds of the present invention associated with the surface thereof. The compounds of the present invention are comprised of a non-polar polyether covalently linked to an anionic sulfonate group. The compounds have an amphipathic quality and preferably, are surface active. Such compounds are preferably useful as surface-active agents to coat and stabilize dispersions of particles in a continuous liquid medium. These surface-active agents may be applied in the stabilization of suspensions, emulsions, or liposome formulations intended for pharmaceutical, medical, cosmetic, or agricultural use. The particles that can be prepared by a variety of methods and will preferably comprise a pharmaceutical agent.Type: GrantFiled: December 15, 2005Date of Patent: August 17, 2010Assignees: Baxter International, Baxter Healthcare S.A.Inventors: James E. Kipp, Ton That Hai, Bennett P. Melnick
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Publication number: 20100197817Abstract: A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.Type: ApplicationFiled: April 13, 2010Publication date: August 5, 2010Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.Inventors: Tuan Bui, Ton That Hai, Mark Nordhaus, Paul Sanders, Cong Jiang, David Lamb, Ozlem Yardimci
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Publication number: 20090314707Abstract: Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.Type: ApplicationFiled: May 29, 2009Publication date: December 24, 2009Applicant: BAXTER INTERNATIONAL INC.Inventors: Sujatha Karoor, Brian Donovan, Ton That Hai, Mari Katada, Luis Lu, Leo Martis, Stavroula Morti, Salim Mujais, Paul J. Sanders, Paul J. Soltys, Rahul Tandon
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Publication number: 20090301958Abstract: Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.Type: ApplicationFiled: August 13, 2009Publication date: December 10, 2009Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.Inventors: Sujatha Karoor, Brian Donovan, Ton That Hai, Mari Katada, Luis Lu, Leo Martis, Stavroula Morti, Salim Mujais, Paul J. Sanders, Paul J. Soltys, Rahul Tandon
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Publication number: 20090218288Abstract: Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.Type: ApplicationFiled: May 13, 2009Publication date: September 3, 2009Applicant: BAXTER INTERNATIONAL INC.Inventors: Sujatha Karoor, Brian Donovan, Ton That Hai, Mari Katada, Luis Lu, Leo Martis, Stavroula Morti, Salim Mujais, Paul J. Sanders, Paul J. Soltys, Rahul Tandon
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Publication number: 20090024096Abstract: A method for immobilizing dyes and antimicrobial agents on a porous surface is disclosed and described. The surface may be that of a medical device, such as a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, and surfaces of an infusion pump. The surfaces may also be one or more of those associated with a dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.Type: ApplicationFiled: July 20, 2007Publication date: January 22, 2009Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.Inventors: TON THAT HAI, Mark A. Nordhaus, Vadim V. Krongauz, Kent L. Lurvey
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Patent number: 7384558Abstract: Therapeutic compositions are provided. The compositions include a single molecule that can display both antioxidant and carbonyl trapping properties. This can effectively reduce inflammation, oxidative stress and carbonyl stress, such as to prevent and/or treat cardiovascular disease and inflammatory diseases in kidney disease patients.Type: GrantFiled: July 26, 2004Date of Patent: June 10, 2008Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Ton That Hai, Mark Nordhaus, Paul Sanders, Cong Jiang, Sujatha Karoor, Ben Melnick, Leo Martis
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Publication number: 20080107564Abstract: An access device including access site is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.Type: ApplicationFiled: October 18, 2006Publication date: May 8, 2008Inventors: Shmuel Sternberg, Kent L. Lurvey, Robin G. Pauley, Dustin C. Cawthon, Ton That Hai, Lecon Woo, Ashok K. Khanna, Birendra K. Lal, Michael Tung-Kiung Ling, Vadim V. Krongauz, Rosa H. Yeh, William S. Hoerle, Craig L. Sandford