Patents by Inventor Tong-Jian Shen

Tong-Jian Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Low oxygen affinity mutant hemoglobins
    Patent number: 6812328
    Abstract: Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: November 2, 2004
    Assignee: Carnegie Mellon University
    Inventors: Chien Ho, Ching-Hsuan Tsai, Tsuei-Yun Fang, Tong-Jian Shen
  • Low oxygen affinity mutant hemoglobins
    Patent number: 6808898
    Abstract: Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: October 26, 2004
    Assignee: Carnegie Mellon University
    Inventors: Chien Ho, Ching-Hsuan Tsai, Tsuei-Yun Fang, Tong-Jian Shen
  • Low oxygen affinity mutant hemoglobins
    Patent number: 6803212
    Abstract: Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: October 12, 2004
    Assignee: Carnegie Mellon University
    Inventors: Chien Ho, Ching-Hsuan Tsai, Tsuei-Yun Fang, Tong-Jian Shen
  • Low oxygen affinity mutant hemoglobins
    Publication number: 20020193293
    Abstract: Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.
    Type: Application
    Filed: November 9, 2001
    Publication date: December 19, 2002
    Inventors: Chien Ho, Ching-Hsuan Tsai, Tsuei-Yun Fang, Tong-Jian Shen
  • Low oxygen affinity mutant hemoglobins
    Patent number: 6486123
    Abstract: Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.
    Type: Grant
    Filed: June 21, 2000
    Date of Patent: November 26, 2002
    Assignee: Carnegie Mellon University
    Inventors: Chien Ho, Ching-Hsuan Tsai, Tsuei-Yun Fang, Tong-Jian Shen
  • Low oxygen affinity mutant hemoglobins
    Publication number: 20020151468
    Abstract: Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation, The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.
    Type: Application
    Filed: November 9, 2001
    Publication date: October 17, 2002
    Inventors: Chien Ho, Ching-Hsuan Tsai, Tsuei-Yun Fang, Tong-Jian Shen
  • Low oxygen affinity mutant hemoglobins
    Publication number: 20020151469
    Abstract: Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.
    Type: Application
    Filed: November 9, 2001
    Publication date: October 17, 2002
    Inventors: Chien Ho, Ching-Hsuan Tsai, Tsuei-Yun Fang, Tong-Jian Shen
  • Low oxygen affinity mutant hemoglobin
    Patent number: 5843888
    Abstract: A non-naturally occurring mutant hemoglobin (.alpha.96Val.fwdarw.Trp) is provided that has a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. The mutant hemoglobin is preferably obtained by recombinant DNA techniques. Such a mutant hemoglobin may be used as a component of a blood substitute.
    Type: Grant
    Filed: May 1, 1995
    Date of Patent: December 1, 1998
    Assignee: Carnegie Mellon University
    Inventors: Chien Ho, Hyun-Won Kim, Tong-Jian Shen
  • Unmodified recombinant human adult hemoglobin production
    Patent number: 5753465
    Abstract: Methods for obtaining unmodified recombinant human normal adult hemoglobin involve a novel expression plasmid that coexpresses human .alpha.- and .beta.-globin genes and E. coli methionine aminopeptidase genes under the control of separate tac promoters. Methods are also provided for correcting an abnormal conformation of some of the heme groups incorporated in the proteins expressed by the expression plasmid.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: May 19, 1998
    Assignee: Carnegie Mellon University
    Inventors: Chien Ho, Tong-Jian Shen