Patents by Inventor Tong Xiao

Tong Xiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES
    Publication number: 20120283433
    Abstract: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Application
    Filed: July 6, 2012
    Publication date: November 8, 2012
    Inventors: Neelakandha S. Mani, David C. Palmer, Chennagiri R. Pandit, Mayra B. Reyes, Tong Xiao, Sergio Cesco-Cancian
  • EVENT SCHEDULER FOR AN ELECTRICAL CIRCUIT DESIGN TO ACCOUNT FOR HOLD TIME VIOLATIONS
    Publication number: 20120240089
    Abstract: Implementations of the present disclosure involve an apparatus and/or method for identifying and classify nodes of an electrical circuit design to account for hold time violations occurring within the circuit. The nodes may be ordered based on a criticality of the nodes that may aid in identifying those nodes of the circuit where hold time violations may be corrected. In one embodiment, the criticality may relate to the number of potentially violating paths that utilize the identified nodes such that corrective measures applied at those nodes may correct several hold time violating paths. In addition, criticality may be scaled utilizing an available buffer library and other timing information.
    Type: Application
    Filed: March 16, 2011
    Publication date: September 20, 2012
    Applicant: ORACLE INTERNATIONAL CORPORATION
    Inventor: Tong Xiao
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
    Publication number: 20120184740
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 19, 2012
    Inventors: Sergio Cesco-Cancian, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Tong Xiao, Diego Broggini, Susanne Lochner
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatgives
    Publication number: 20120178932
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 12, 2012
    Inventors: Sergio CESCO-CANCIAN, Jeffrey S. GRIMM, Neelakandha S. MANI, Christopher M. MAPES, David C. PALMER, Daniel J. PIPPEL, Tong XIAO, Diego BROGGINI, Susanne LOCHNER
  • Synthesis of quaternary salt compounds
    Patent number: 8168829
    Abstract: The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: May 1, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: David C. Palmer, Sergio Casco-Cancian, Tong Xiao, Kirk L. Sorgi, Armin Roessler, Anita Vladislavic, Roger Faessler
  • NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES
    Publication number: 20120029191
    Abstract: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Application
    Filed: October 11, 2011
    Publication date: February 2, 2012
    Inventors: Neelakandha S. Mani, David C. Palmer, Chennagiri R. Pandit, Mayra B. Reyes, Tong Xiao, Sergio Cesco-Cancian
  • Processes for the preparation of cyclopropyl-amide derivatives
    Patent number: 8063206
    Abstract: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: November 22, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Neelakandha S. Mani, David C. Palmer, Chennagiri R. Pandit, Mayra B. Reyes, Tong Xiao, Sergio Cesco-Cancian
  • NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES
    Publication number: 20100286391
    Abstract: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Application
    Filed: July 20, 2010
    Publication date: November 11, 2010
    Inventors: Neelakandha S. Mani, David C. Palmer, Chennagiri R. Pandit, Mayra B. Reyes, Tong Xiao, Sergio Cesco-Cancian
  • Processes for the preparation of cyclopropyl-amide derivatives
    Patent number: 7795426
    Abstract: The present invention relates to processes for the preparation of cyclopropyl-amine derivatives of formula (II), as defined in the specification, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: September 14, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Neelakandha S. Mani, David C. Palmer, Chennagiri R. Pandit, Mayra B. Reyes, Tong Xiao, Sergio Cesco-Cancian
  • NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES
    Publication number: 20100197689
    Abstract: The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Application
    Filed: April 19, 2010
    Publication date: August 5, 2010
    Inventors: Neelakandha S. Mani, David C. Palmer, Chennagiri R. Pandit, Mayra B. Reyes, Tong Xiao, Sergio Cesco-Cancian
  • Processes for the preparation of piperazinyl and diazapanyl benzamide derivatives
    Patent number: 7728129
    Abstract: The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides of formula (I), as defined in the specification, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Grant
    Filed: October 26, 2006
    Date of Patent: June 1, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Neelakandha S. Mani, David C. Palmer, Chennagiri R. Pandit, Mayra B. Reyes, Tong Xiao, Sergio Cesco-Cancian
  • Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
    Publication number: 20100029942
    Abstract: The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
    Type: Application
    Filed: June 29, 2009
    Publication date: February 4, 2010
    Inventors: Sergio Cesco-Cancian, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Tong Xiao, Diego Broggini, Susanne Lochner
  • Process for the preparation of substituted pyrimidine derivatives
    Publication number: 20100004450
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Application
    Filed: June 29, 2009
    Publication date: January 7, 2010
    Inventors: Sergio Cesco-Cancian, Hongfeng Chen, Jeffrey S. Grimm, Neelakandha S. Mani, Christopher M. Mapes, David C. Palmer, Daniel J. Pippel, Kirk L. Sorgi, Tong Xiao
  • SYNTHESIS OF QUATERNARY SALT COMPOUNDS
    Publication number: 20090112004
    Abstract: The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.
    Type: Application
    Filed: October 22, 2008
    Publication date: April 30, 2009
    Inventors: David C. Palmer, Sergio Casco-Cancian, Tong Xiao, Kirl L. Sorgi, Armin Roessler, Anita Vladislavic, Roger Faessler
  • NOVEL PROCESSES FOR THE PREPARATION OF PIPERAZINYL AND DIAZAPANYL BENZAMIDE DERIVATIVES
    Publication number: 20070197508
    Abstract: The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Application
    Filed: October 26, 2006
    Publication date: August 23, 2007
    Inventors: Neelakandha Mani, David Palmer, Chennagiri Pandit, Mayra Reyes, Tong Xiao, Sergio Cesco-Cancian
  • NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES
    Publication number: 20070129351
    Abstract: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
    Type: Application
    Filed: October 26, 2006
    Publication date: June 7, 2007
    Inventors: Neelakandha Mani, David Palmer, Chennagiri Pandit, Mayra Reyes, Tong Xiao
  • Process for the preparation of substituted triazole compounds
    Publication number: 20060100259
    Abstract: The present invention is directed to a novel process for the preparation of substituted triazole compounds, useful in the treating or ameliorating a selective kinase or dual-kinase mediated disorder. The process of the present invention preferentially produces the desired regioisomer of the substituted triazole compounds.
    Type: Application
    Filed: January 21, 2005
    Publication date: May 11, 2006
    Inventors: David Palmer, Kirk Sorgi, Tong Xiao, Sergio Cesco-Cancian
  • Synthesis of piperidine and piperazine compounds as CCR5 antagonists
    Patent number: 6992189
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: January 31, 2006
    Assignee: Schering Corporation
    Inventors: William Leong, Minzhang Chen, Bosco A. D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew J. Goodman, Christopher M. Nielsen, Gary M. Lee, Juan A. Gamboa, Andrew D. Jones
  • Synthesis of piperidine and piperazine compounds as CCR5 antagonists
    Publication number: 20050187248
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:
    Type: Application
    Filed: March 24, 2005
    Publication date: August 25, 2005
    Inventors: William Leong, Minzhang Chen, Bosco D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew Goodman, Christopher Nielsen, Gary Lee, Juan Gamboa, Andrew Jones
  • Abstraction generation for hierarchical timing analysis using implicity connectivity graph derived from domain propagation
    Publication number: 20050091555
    Abstract: A method of using static timing analysis to extract implicit connectivity graph information. The method includes creating a unique clock waveform, defining a clock domain for the clock waveform, injecting the clock domain into a control node, propagating timing events from the control node to a transitively adjacent observation node, and retrieving transitively adjacent control node information to determine path delay information from the control node to the transitively adjacent observation node based upon propagation of timing events.
    Type: Application
    Filed: October 27, 2003
    Publication date: April 28, 2005
    Inventors: Tong Xiao, Robert Mains