Abstract: The present invention discloses a multi-energy complementary system for a co-associated abandoned mine and a use method. The multi-energy complementary system for a co-associated abandoned mine includes a mining mechanism, a grouting mechanism and an energy mechanism. In the present invention, the mining of coal and uranium resources is realized through the mining mechanism, the subsidence and seepage reduction of the stratum is realized through the grouting mechanism, and the effective utilization of waste resources is realized through the energy mechanism. Finally, with the efficient cooperation of the three mechanisms, safe and efficient development and utilization of co-associated resources in the full life cycle are realized, and the purposes of green and efficient mining of coal and uranium resources and secondary development of a coal seam goaf are achieved, thereby facilitating the realization of dual-carbon goals and the development of low-carbon green energy.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: Provided is a use of a mitoxantrone hydrochloride liposome in the preparation of a drug for treating urothelial cancer, breast cancer, and bone and soft tissue sarcoma. Further provided is a method for treating urothelial cancer, breast cancer, and bone and soft tissue sarcoma, and the method is to administer a therapeutically effective amount of mitoxantrone hydrochloride liposomes to a patient in need. The mitoxantrone hydrochloride liposome can effectively treat urothelial cancer, breast cancer, and bone and soft tissue sarcoma, and compared with common mitoxantrone hydrochloride injections, the mitoxantrone hydrochloride liposome has better therapeutic effect and fewer adverse reactions.

Abstract: A shift-register unit, a grid driving circuit and a displaying device, which relates to the technical field of displaying. In the present disclosure, the oxide-semiconductor layers of the oxide thin-film transistors may be delimited into regions according to the total channel widths and the channel lengths required by the oxide thin-film transistors in the shift-register unit, wherein the sum of the widths of the independent semiconductor branches obtained by the delimitation is equal to the required total channel width. Accordingly, one oxide thin-film transistor can realize the required total channel width by using the one or more semiconductor branches, to ensure the normal operation of the oxide thin-film transistor, whereby the oxide-semiconductor layers of the different oxide thin-film transistors can be configured differently, to realize the purpose of reducing the border frame of the displaying device.

Abstract: Embodiments of the present application provide a method for controlling voltages of a liquid crystal on silicon (LCoS) two-dimensional array which includes a plurality of pixel sets, and the plurality of pixel sets include a first pixel set and a second pixel set. The method includes: determining a plurality of bit sequences, where the plurality of bit sequences include a first bit sequence and a second bit sequence; controlling a voltage of the first pixel set by using the first bit sequence; and controlling a voltage of the second pixel set by using the second bit sequence, where the first pixel set and the second pixel set are in different phase cycles in a port direction of the LCoS two-dimensional array, the first pixel set and the second pixel set have a same phase, and duty ratios of the first bit sequence and the second bit sequence are the same.

Abstract: A surgical instrument (10) includes a housing (20) defining a longitudinal axis and a first assembly (200) and a second assembly (300) operably coupled to the housing (20). The first assembly (200) includes a first function button (200b) pivotably coupled to the housing (20) about a first pivot (200p) and a first circuit (210) supported by the housing (20) and aligned with the first pivot (200p). The first function button (200b) includes a first arm (201) on a first side of the first pivot (200p) and a second arm (202) on a second side of the first pivot (200p). The first circuit (210) is aligned with the cutting picot between the first arm (201) and the second arm (202) and includes a first actuator (211) on the first side of the first pivot (200p) and a second actuator (212) on the second side of the first pivot (200p).

Abstract: Certain aspects of the present disclosure provide techniques and apparatus for a training and using machine learning models in multi-device network environments. An example computer-implemented method for network communications performed by a host device includes extracting a feature set from a data set associated with a client device using a client-device-specific feature extractor, wherein the feature set comprises a subset of features in a common feature space, training a task-specific model based on the extracted feature set and one or more other feature sets associated with other client devices, wherein the feature sets associated with the other client devices comprise one or more subsets of features in the common feature space, and deploying, to each respective client device of a plurality of client devices, a respective version of the task-specific model.

Abstract: The present disclosure provides interferon receptor agonists with improved safety profiles and therapeutic indices. The interferon receptor agonists are attenuated through masking and/or reduced receptor binding as compared to a wild-type interferon. IFN receptor agonists optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor- or immune cell-associated antigen and directs the interferon receptor agonist to a tumor site and/or tumor-reactive immune cells. The disclosure further provides pharmaceutical compositions comprising the interferon receptor agonists, and methods of use of the interferon receptor agonists in therapy, as well as nucleic acids encoding the interferon receptor agonists, recombinant cells that express the interferon receptor agonists and methods of producing the interferon receptor agonists.

Abstract: The present application provides a preparation method for a core-shell structured tungsten/gadolinium oxide functional fiber for X and ? ray protection, comprising: first preparing a core-shell structured tungsten/gadolinium oxide powder; preparing a W@Gd2O3/PP blended melt from the powder; and preparing a W@Gd2O3/PP composite fiber from the blended melt. The core-shell structured tungsten/gadolinium oxide functional fiber prepared by the method can play a role in synergistic protection in the aspect of radiation protection, eliminate a weak protection area, and effectively absorb secondary radiation generated by radiation. Secondly, the prepared functional fiber has the characteristics of no lead and light weight, and has good application prospects in the aspect of X and ? ray radiation protection.

Abstract: The present disclosure provides systems and methods for ultrasound image processing. The methods include obtaining a first ultrasound image and a second ultrasound image of a target subject. The first ultrasound image and the second ultrasound image include a linear interventional device within the target subject. The methods include identifying one or more line segments in the second ultrasound image by processing the second ultrasound image using a first line detection algorithm. For each of the one or more line segments, the methods include determining a corrected line segment by processing a target region in the second ultrasound image corresponding to the line segment using a second line detection algorithm. The methods include generating a fused ultrasound image of the first ultrasound image and the second ultrasound image based on one or more corrected line segments corresponding to the one or more line segments.

Abstract: A method for interaction between devices based on a pointing operation and an electronic device. The electronic device may be a mobile phone or the like. In the method, a pointing operation performed by a user from a handheld device to a target device is detected via an acceleration sensor, a gyroscope, an IMU, a camera, or the like of the handheld device, and a wireless positioning function of the handheld device is triggered. When it is identified that an axis of the handheld device intersects or approximately intersects with the target device, at least one type of feedback such as visual feedback, sound feedback, and vibration may be provided on the handheld device and/or the target device, login account information and device information of the target device are transmitted to the handheld device, and a target device control window is displayed on the handheld device.

Abstract: The present disclosure provides interferon receptor agonists with improved safety profiles and therapeutic indices. The interferon receptor agonists are attenuated through masking and/or reduced receptor binding as compared to a wild-type interferon. IFN receptor agonists optionally further comprise a targeting moiety, e.g., a targeting moiety that recognizes a tumor- or immune cell-associated antigen and directs the interferon receptor agonist to a tumor site and/or tumor-reactive immune cells. The disclosure further provides pharmaceutical compositions comprising the interferon receptor agonists, and methods of use of the interferon receptor agonists in therapy, as well as nucleic acids encoding the interferon receptor agonists, recombinant cells that express the interferon receptor agonists and methods of producing the interferon receptor agonists.

Abstract: A B7-H3 targeting antibody-drug conjugate, and a preparation method therefor and use thereof. Provided is the antibody-drug conjugate as shown in formula I. The compound has a good targeting property, good inhibitory effect on tumor cells positively expressing B7-H3, and good druggability and safety. The present antibody-drug conjugate has an inhibitory effect against B7-H3, and also a good inhibitory effect against at least one of NCI-N87, A375, LN-229, PA-1, MDA-MB-468, Calu-6 and HS-700T cells.

Abstract: A TROP2 targeting antibody-drug conjugate, and a preparation method and use therefor. The antibody-drug conjugate is shown in formula I. Said type of compound has a good targeting property, a good inhibitory effect on tumor cells positively expressing TROP2, and good druggability and high safety. The present antibody drug conjugate has an inhibitory effect on TROP2, and also a good inhibitory effect on at least one of NCI-N87, MDA-MB-468 and BXPC3 cells.

Abstract: The present disclosure provides a method for performing a non-revisiting coverage task by a manipulator with a least number of lift-offs, and relates to the technical field of manipulator path planning. By explicitly considering lift-offs of an end-effector from a surface of an object due to kinematic constraints when the manipulator performs a task of covering the surface of the object, this method transforms a problem of coverage path design into a problem of sub-cell decomposition and solves the problem to obtain an approach for the manipulator to cover a sub-cell. The method of the present disclosure minimizes the number of lift-offs of the end-effector from the surface of the object when the manipulator performs the coverage task.

Abstract: A display method includes displaying an application on a screen in a first mode and receiving an operation performed on the screen, where the operation is any operation in a plurality of consecutive operations. The consecutive operations include any one or any combination of a same operation mode, a same operation object, and a same region for an operation object, and the same operation mode includes either or both of a same operation gesture and a same operation direction for an operation gesture. Switching, in response to the operation, display of the application from the first mode to a second mode, where each of the first mode and the second mode is any one of a full-screen mode, a window mode, a card mode, or a floating ball mode.

Abstract: Provided is a display panel. The display panel comprises an array substrate and a color filter substrate, wherein the color filter substrate comprises a second substrate and a black matrix pattern, wherein the black matrix pattern comprises a body, via hole shielding parts, and compensation shielding parts, the via hole shielding parts being disposed within first domains of part of plurality of sub-pixel regions, the compensation shielding parts being disposed within second domains that are adjacent in first direction to the first domains where the via hole shielding parts are disposed, and at most one of the via hole shielding part and the compensation shielding part being disposed in one sub-pixel region.

Abstract: An antibody-drug conjugate, and an intermediate thereof, a preparation method therefor, and an application thereof. Provided is an antibody-drug conjugate as represented by formula I. The compound has good targetability, has a good inhibitory effect on HER3-positive tumor cells, and has good druggability and high safety. The antibody-drug conjugate has an inhibitory effect on HER3, has an inhibitory effect on SK-BR-3 and SW620 cells, and also has a good inhibitory effect on at least one of 22Rv1, LNCaP, NCI-H820, OVCAR-8, and HCC827 cells.

Abstract: The present disclosure relates to a push method, push apparatus of video and storage medium, and relates to the technical field of multimedia technologies. The push method of video includes: acquiring videos comprising video(s) with a photosensitive tag and video(s) without a photosensitive tag, wherein each video has a photosensitive tag if it is determined as a photosensitive video by a photosensitive video recognition model; and pushing video(s) that do not have a photosensitive tag among the videos to a browsing user in case that the browsing user is in a state of photosensitive video filtering.

Abstract: There is provided a display panel including: a light guide structure layer having a light exiting side and configured to enable internal light to be emitted from a preset position; a display structure layer on the light exiting side and including a light adjusting structure, a black matrix and a reflection matrix positioned on a side, away from the light guide structure layer, of the light adjusting structure, the light adjusting structure is configured to control light emitted from the preset position to enter an area where the black matrix is positioned and/or an area where the reflection matrix is positioned; a light absorption structure layer on a side of the light adjusting structure away from the black matrix and configured to absorb light reflected by the black matrix and allow light reflected by the reflection matrix to pass through. A display device is further provided.