Abstract: The present disclosure relates to the field of biotechnologies. Specifically disclosed are an interferon signaling pathway-related gene panel and an in vitro diagnostic product thereof, and the use of the same in assessing the recurrence risk of breast cancer and/or providing guidance for breast cancer treatment with interferon.

Abstract: Various embodiments of the teachings herein include methods for implementing communication conversion between a server-client system and a publish-subscribe (pub-sub) system. An example may include: receiving a message from the pub-sub system, wherein a topic of the message includes information related to a target service in the server-client system to which the message is to be sent, and a payload of the message includes identification information of a consumer in the pub-sub system, wherein the consumer is to receive a response message from the server-client system; parsing the message to determine a host and a service provider that provide the target service, and the consumer who is to receive the response message; sending a request message for the target service to the service provider on the determined host; receiving the response message; adding the identification information to the response message; and sending it to the pub-sub system.

Abstract: A method for switching transmission methods in a multiple input multiple output (MIMO) system may include: receiving scenario identification related data from a user equipment (UE) in a current transmission method; determining a target transmission method of the UE from at least two predefined transmission methods based on the scenario identification related data; and switching the current transmission method of the UE to the target transmission method.

Abstract: Embodiments of the disclosed technologies receive, for a first machine learning task, a first set of raw features arranged according to a first schema, and, for a second machine learning task, a second set of raw features arranged according to a second schema different than the first schema. A multi-task raw feature set is created by storing, in a data store arranged according to a common schema, the first and second sets of raw features. A common feature that is common to both the first and second sets of raw features is identified. A multi-task transformed feature set and a model bundle are created. The multi-task transformed feature set is separated into first and second sets of transformed features. The first and second sets of transformed features and the model bundle can be used to create a trained multi-task machine learning model.

Abstract: In accordance with an embodiment, described herein are systems and methods for providing direct access to a sharded database. A shard director provides access by software client applications to database shards. A connection pool (e.g., a Universal Connection Pool, UCP) and database driver (e.g., a Java Database Connectivity, JDBC, component) can be configured to allow a client application to provide a shard key, either during connection checkout or at a later time; recognize shard keys specified by the client application; and enable connection by the client application to a particular shard or chunk. The approach enables efficient re-use of connection resources, and faster access to appropriate shards.

Abstract: A pharmaceutical composition comprising: i) a herpes gE protein, an active fragment of the protein, a variant of the protein, or a mixture of at least two of them; ii) an immunostimulatory composition comprising a saponin and a CpG oligodeoxynucleotide, or consisting of an adjuvant comprising a saponin and a CpG oligodeoxynucleotide. Use of the pharmaceutical composition in the preparation of a medicament for preventing and/or treating a varicella-zoster virus infection and/or a varicella-zoster virus mediated disease. The pharmaceutical composition achieves an unexpected technical effect and can mediate a stronger immune response.

Abstract: The present invention belongs to the field of biopharmaceutics and in particular relates to a pharmaceutical composition. The pharmaceutical composition comprises a hepatitis B surface antigen, a hepatitis B core antigen, and an immunostimulatory composition, wherein the immunostimulatory composition comprises a saponin and a CpG oligodeoxynucleotide, or consists of an adjuvant comprising a saponin and a CpG oligodeoxynucleotide.

Abstract: A bridge structure dynamic response of a bridge structure under the action of heavy duty vehicle load is obtained through sensors arranged on the bridge structure; according to vertical vibration acceleration ao and vertical deflection yo of the bridge at a center of gravity o of the heavy duty vehicle and speed of the heavy duty vehicle Uvehicle, a response of a table top of a vibration table is reconstructed, and interaction force of the vehicle-bridge coupling model is obtained; a nonlinear finite element model of the bridge structure is established, and the vehicle-bridge interaction force is taken as external force, and the dynamic response of the bridge structure is taken as a structural response, and modification of the finite element model of the bridge structure is completed through a nonlinear parameter identification method. The invention is mainly used for updating a bridge model.

Abstract: Techniques are described herein for predicting disk drive failure using a machine learning model. The framework involves receiving disk drive sensor attributes as training data, preprocessing the training data to select a set of enhanced feature sequences, and using the enhanced feature sequences to train a machine learning model to predict disk drive failures from disk drive sensor monitoring data. Prior to the training phase, the RNN LSTM model is tuned using a set of predefined hyper-parameters. The preprocessing, which is performed during the training and evaluation phase as well as later during the prediction phase, involves using predefined values for a set of parameters to generate the set of enhanced sequences from raw sensor reading. The enhanced feature sequences are generated to maintain a desired healthy/failed disk ratio, and only use samples leading up to a last-valid-time sample in order to honor a pre-specified heads-up-period alert requirement.

Abstract: Provided is an immunostimulatory composition, comprising a saponin and a CpG oligodeoxynucleotide, or consisting of an adjuvant comprising a saponin and a CpG oligodeoxynucleotide, wherein the sequence of the CpG oligodeoxynucleotide has two or more copies of 5?-TTCGTT-3? motif or 5?-TCGTCGTCG-3? motif. Also provided is use of the immunostimulatory composition in the preparation of a medication for treating diseases.

Abstract: Systems and methods for positive dispense verification. In one aspect, a system has a plurality of light emitters. The light from the emitters is directed toward a plurality of light detectors across a proximately horizontal plane. The liquid dispense device is positioned above the horizontal plane of light emission from the plurality of light emitters to the plurality of light detectors such that the dispensed liquid will travel through the horizontal plane defined by the emitted light and onto the container being inoculated. Each of the plurality of detectors is coupled to an amplifier. The amplifier generates a signal in response to an interrupt in the transmission of light from the light emitters to the light detectors when the light path is disrupted by the dispense of liquid confirming the liquid was dispensed onto the container.

Abstract: A mirror therapy device includes a first positioning assembly, a second positioning assembly and a transmission assembly connecting the first and second positioning assemblies. The first and second positioning assemblies are arranged in opposition to each other in such a manner that both are able to reciprocate. The first positioning assembly is configured for positioning of a healthy limb of a patient, and the second positioning assembly is configured for positioning of an affected limb of the patient. The transmission assembly is configured for power transmission between the first and second positioning assemblies so that the second positioning assembly moves in synchronization with the first positioning assembly under the action of the transmission assembly. A mirror therapy system includes the mirror therapy device and a display device.

Abstract: Techniques are disclosed herein for identifying, recording and restoring the state of a database session and various aspects thereof. A session template data structure is generated that includes session attribute values describing various aspects of the session that is established between a client system and a database management system (DBMS and enables the client system to issue to the DBMS commands for execution. Based on the session attribute values, DBMS may generate a template identifier corresponding to the session template data structure. The template identifier may be stored in an association with the session state that it partially (or in whole) represents. In an embodiment, when another state of a session is captured, if the template identifier for the state is the same, then rather than storing the attribute-value pairs for the other state, the template identifier is further associated with the other state.

Abstract: Disclosed is a gene panel which can evaluate lung adenocarcinoma molecular subtype and survival risk, and an application of a reagent, which detects the gene expression level of the gene panel, in preparing a product. The product is used for determining lung adenocarcinoma molecular subtype and evaluating lung adenocarcinoma patient survival risk. The product comprises a Next-Generation Sequencing (NGS) detection reagent kit, a fluorescence quantitative PCR detection reagent kit, a gene chip and a protein microarray. Also disclosed is a method which uses the detection reagent kits to evaluate lung adenocarcinoma molecular subtype and survival risk.

Abstract: A terminal, includes: multiple antenna ports, configured to connect antennas; a first determining unit, configured to determine a power scaling factor and indication information, and determine capability information of the terminal according to the power scaling factor and the indication information; a sending unit, configured to receive the capability information and send the capability information to a network device; a second determining unit, configured to determine a actual uplink transmission power of the terminal according to feedback information of the network device and the capability information.

Abstract: Techniques are provided herein for contextual embedding of features of operational logs or network traffic for anomaly detection based on sequence prediction. In an embodiment, a computer has a predictive recurrent neural network (RNN) that detects an anomalous network flow. In an embodiment, an RNN contextually transcodes sparse feature vectors that represent log messages into dense feature vectors that may be predictive or used to generate predictive vectors. In an embodiment, graph embedding improves feature embedding of log traces. In an embodiment, a computer detects and feature-encodes independent traces from related log messages. These techniques may detect malicious activity by anomaly analysis of context-aware feature embeddings of network packet flows, log messages, and/or log traces.

Abstract: Provided is an isolated antibody or antigen-binding fragment thereof that binds specifically to human CD-L1 protein, a nucleic acid molecule encoding the same, therapeutic compositions thereof, and their use to treat a PD-L1 related disease, such as a tumor which is PD-L1 positive.

Abstract: In accordance with an embodiment, the system enables access to a sharded database using a cache and a shard topology. A shard-aware client application connecting to a sharded database can use a connection pool (e.g., a Universal Connection Pool, UCP), to store or access connections to different shards or chunks of the sharded database within a shared pool. As new connections are created, a shard topology layer can be built at the database driver layer, which learns and caches shard key ranges to locations of shards. The shard topology layer enables subsequent connection requests from a client application to use a fast key path access to the appropriate shard or chunk.