Abstract: A radiative cooling apparatus including a layer of a material. The layer defines an exterior face. The material has a composition such that the layer is configured to reflect, at the exterior face, at least partly of the incoming electromagnetic radiation of at least some wavelengths in the solar spectrum. The layer is further configured to emit thermally-generated electromagnetic emission of at least some mid-infrared wavelengths out from the exterior face. Ceramics provided by embodiments of the invention could produce extra cooling effect without any electricity consumption, creating a prominent benefit to the energy saving of air conditioning systems of buildings.

Abstract: Embodiments of this application provide a route advertisement method, a network device, and a system. A first network device receives a route advertisement packet from a second network device, where the route advertisement packet includes a common field and a variable field, the common field carries a common part of N segment routing over internet protocol version 6 SRv6 segment identifiers SIDs, the variable field carries a variable part of a first SRv6 SID in the N SRv6 SIDs, the N SRv6 SIDs correspond to a first prefix, and N is a positive integer greater than or equal to 2. The first network device obtains the N SRv6 SIDs based on the common part and the variable part of the first SRv6 SID. The first network device generates a first route, where the first route includes the first prefix and the N SRv6 SIDs.

Abstract: A packet processing method and a network device are provided. The method is applied to a network system, and the network system includes a first network device and a plurality of network devices separately connected to the first network device. The method includes: The first network device groups the plurality of network devices into a plurality of groups based on a service, where each of the plurality of groups includes at least one network device. The first network device determines one or more groups in the plurality of groups, and forwards packets of the service to one or more of the plurality of network devices in the one or more groups. In present application, a mode for forwarding the packets of the service can be flexibly selected according to a service requirement, to better meet the service requirement.

Abstract: In one aspect, an active agent-conjugate, methods of preparing the active agent-conjugate, and uses thereof is provided.

Abstract: Embodiments of this application provide a DF election method and a device. The method is performed by a first network device, and the method includes: receiving an EVPN Ethernet segment ES route advertised by a second network device, where the ES route includes an ESI, the ESI identifies an Ethernet segment, and the Ethernet segment includes a first link and a second link, where the first network device and the second network device each are configured with a first broadcast domain, a first gateway accesses the first broadcast domain of the first network device through the first link, a second gateway accesses the first broadcast domain of the second network device through the second link, the first network device and the second network device each configure the ESI in the first broadcast domain, and the first gateway and the second gateway access a same EVPN site; and performing DF election based on the ES route, to determine that the first network device is a non-DF in the first broadcast domain.

Abstract: A route advertisement method, a network device, and a computer storage medium are provided, and pertain to the field of communication technologies. According to this application, an EVPN SRv6 route advertisement packet is extended to carry pseudo-wire identification information of an L2VPN PW between a first network device and a second network device, to help find, based on the pseudo-wire identification information, a forwarding entry associated with the L2VPN PW, and further process the forwarding entry associated with the L2VPN PW, thereby evolving an MPLS forwarding-based L2VPN VPWS into an SRv6 forwarding-based EVPN VPWS, or evolving an MPLS forwarding-based L2VPN VPLS into an SRv6 forwarding-based EVPN VPLS. In addition, the MPLS forwarding-based L2VPN VPWS or VPLS can be evolved into another type of EVPN SRv6 network.

Abstract: Provided, inter alia, are antibody drug conjugates (ADCs) which specifically bind B Cell Maturation Antigen (BCMA). Further disclosed are pharmaceutical compositions, and methods for treating cancer.

Abstract: The use of a genetic method to down-regulate RBO/EFR3/EFR3A/EFR3B proteins, TTC7 protein or PI4KIII? enzyme protein which interacts with RBO/EFR3/EFR3A/EFR3B proteins and TTC7 protein, or the use of a drug to inhibit PI4KIII? protein kinase activity reduces the accumulation of A?42 within neurons and age-dependent synaptic transmission failure and other obstacles in a fruit fly AD model, and obtains an effect of improving the learning and memory abilities of AD model mice. Provided is a method for using an RBO/EFR3/EFR3A/EFR3B inhibitor, a TTC7 inhibitor and a PI4KIII? inhibitor to treat Alzheimer's disease. Also provided is a method for screening a drug treating Alzheimer's disease by whether A? secretion by nerve cells is promoted or not.

Abstract: Embodiments of this application disclose a segment routing over internet protocol version 6 (SRv6)-based communication method and a related apparatus. A layer 2 gateway generates an Ethernet virtual private network instance (EVI) media access control (EVI-MAC route), where the EVI-MAC route includes an Ethernet virtual private network instance segment identifier (EVI SID), the EVI SID is an SRv6 SID applied for by an EVI from the layer 2 gateway, and a MAC address carried in the EVI-MAC route does not include a MAC address of each host in the EVI. The layer 2 gateway advertises the EVI-MAC route to a layer 3 gateway. After the layer 2 gateway advertises the EVI-MAC route to the layer 3 gateway, the layer 3 gateway does not receive a MAC address of a host from the layer 2 gateway.

Abstract: There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second drug conjugate with a different drug to a Lys residue on the targeting protein.

Abstract: A packet transmission method, device, and system are disclosed, and pertain to the field of network technologies. The system includes a first network device in a VPLS network and a second network device in a VPWS network. The first network device determines, based on a destination address carried in a received first packet, a virtual port corresponding to the destination address in a VPLS instance of the first network device, and sends the first packet to a second VPWS instance in the second network device based on the virtual port, where the virtual port is used to indicate a first VPWS instance in the first network device, and the second VPWS instance and the first VPWS instance are VPWS instances used to bear a same service.

Abstract: This disclosure relates to antibody-drug conjugates (ADCs) comprising an anti-Trop-2 antibody. Provided herein are compositions comprising such ADCs, as well as methods of making and using the same.

Abstract: Provided is a preparation method of an antibody-drug conjugate represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, or a solvate of the foregoing, wherein A, X, Y, L, D and a are as defined herein.

Abstract: A radiative cooling apparatus including a layer of a material. The layer defines an exterior face. The material has a composition such that the layer is configured to reflect, at the exterior face, at least partly of the incoming electromagnetic radiation of at least some wavelengths in the solar spectrum. The layer is further configured to emit thermally-generated electromagnetic emission of at least some mid-infrared wavelengths out from the exterior face. Ceramics provided by embodiments of the invention could produce extra cooling effect without any electricity consumption, creating a prominent benefit to the energy saving of air conditioning systems of buildings.

Abstract: This application provides a communication method and apparatus. The method includes: A first communication apparatus receives a first EVPN MAC route from a second communication apparatus, where the first EVPN MAC route carries a first MAC address and a first VNI. The first communication apparatus generates a second EVPN MAC route based on the first EVPN MAC route, where the second EVPN MAC route carries the first MAC address and a first SID that is of the first communication apparatus and that corresponds to the first VNI. The first communication apparatus sends the second EVPN MAC route to a third communication apparatus. This application implements interconnection between a VXLAN and an SRv6 network.

Abstract: An electronic device includes a main body, a display disposed on the main body, and a sound-making assembly. The sound-making assembly includes a speaker box and a driving diaphragm located in the speaker box, the speaker box is disposed inside the main body or is formed using the main body and the display, where the main body includes a speaker grille corresponding to the speaker box, the driving diaphragm is fastened inside the speaker box and divides the speaker box into two sub-chambers, the speaker grille is coupled to one of the two sub-chambers, the driving diaphragm vibrates after receiving an audio signal, the driving diaphragm drives, through vibration of the driving diaphragm, air in the two sub-chambers to vibrate to make a sound, and the sound is propagated through the speaker grille.

Abstract: A packet transmission method, device, and system are disclosed, and pertain to the field of network technologies. The system includes a first network device in a VPLS network and a second network device in a VPWS network. The first network device determines, based on a destination address carried in a received first packet, a virtual port corresponding to the destination address in a VPLS instance of the first network device, and sends the first packet to a second VPWS instance in the second network device based on the virtual port, where the virtual port is used to indicate a first VPWS instance in the first network device, and the second VPWS instance and the first VPWS instance are VPWS instances used to bear a same service.

Abstract: The use of a genetic method to down-regulate RBO/EFR3/EFR3A/EFR3B proteins, TTC7 protein or PI4KIII? enzyme protein which interacts with RBO/EFR3/EFR3A/EFR3B proteins and TTC7 protein, or the use of a drug to inhibit PI4KIII? protein kinase activity reduces the accumulation of A?42 within neurons and age-dependent synaptic transmission failure and other obstacles in a fruit fly AD model, and obtains an effect of improving the learning and memory abilities of AD model mice. Provided is a method for using an RBO/EFR3/EFR3A/EFR3B inhibitor, a TTC7 inhibitor and a PI4KIII? inhibitor to treat Alzheimer's disease. Also provided is a method for screening a drug treating Alzheimer's disease by whether A? secretion by nerve cells is promoted or not.

Abstract: The present invention provides an anti-ErbB2 antibody-drug conjugate, a composition comprising the conjugate, a method for preparing the conjugate, and use of the conjugate.