Patents by Inventor Tongcheng Qian

Tongcheng Qian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for differentiation of human pluripotent stem cells to brain microvascular endothelial cells
    Patent number: 10214724
    Abstract: Methods for generating functional brain microvascular endothelial cells (BMECs) under chemically defined, serum-free conditions are provided. In particular, efficient and cost-effective methods for generating functional BMECs under chemically defined culture conditions are provided. BMECs obtained according to the methods provided herein are suitable for in vitro blood brain barrier (BBB) formation.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: February 26, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Tongcheng Qian, Eric V. Shusta, Sean P. Palecek
  • METHOD OF DIFFERENTIATING HUMAN PLURIPOTENT STEM CELLS TO PODOCYTES
    Publication number: 20190055520
    Abstract: The present invention provides methods and kits for differentiating podocytes from pluripotent stem cells and from other cell types.
    Type: Application
    Filed: August 20, 2018
    Publication date: February 21, 2019
    Inventors: Tongcheng Qian, Sean P. Palecek, Eric V. Shusta
  • METHODS FOR DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS TO BRAIN MICROVASCULAR ENDOTHELIAL CELLS
    Publication number: 20170283772
    Abstract: Methods for generating functional brain microvascular endothelial cells (BMECs) under chemically defined, serum-free conditions are provided. In particular, efficient and cost-effective methods for generating functional BMECs under chemically defined culture conditions are provided. BMECs obtained according to the methods provided herein are suitable for in vitro blood brain barrier (BBB) formation.
    Type: Application
    Filed: April 4, 2017
    Publication date: October 5, 2017
    Inventors: Tongcheng Qian, Eric V. Shusta, Sean P. Palecek
  • Superhydrophobic poly(dimethylsiloxane) and methods for making the same
    Patent number: 8614003
    Abstract: A hydrophobic coating having a contact angle of at least about 150 degrees is disclosed herein, which coating comprises: a polymer substrate comprising a first linker incorporated therein at a specified surface density of from about 3×10?4 to about 9×10?8 units per nm2; a first polymer layer in contact with said first linker; a second linker in contact with said first polymer layer; and a second polymer layer in contact with said second linker. Also disclosed herein are methods for producing the hydrophobic coating. This hydrophobic coating is useful for making microfluidic devices having a hydrophobic coating on the microfluidic channels, as well as other uses in the field of microfluidics.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: December 24, 2013
    Assignee: Peking University
    Inventors: Hongwei Ma, Tongcheng Qian, Yuanzi Wu
  • Superhydrophobic poly(dimethylsiloxane) and methods for making the same
    Patent number: 8367214
    Abstract: A hydrophobic coating having a contact angle of at least about 150 degrees is disclosed herein, which coating comprises: a polymer substrate comprising a first linker incorporated therein at a specified surface density of from about 3×10?4 to about 9×10?8 units per nm2; a first polymer layer in contact with said first linker; a second linker in contact with said first polymer layer; and a second polymer layer in contact with said second linker. Also disclosed herein are methods for producing the hydrophobic coating. This hydrophobic coating is useful for making microfluidic devices having a hydrophobic coating on the microfluidic channels, as well as other uses in the field of microfluidics.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: February 5, 2013
    Assignee: Peking University
    Inventors: Hongwei Ma, Tongcheng Qian, Yuanzi Wu
  • SUPERHYDROPHOBIC POLY(DIMETHYLSILOXANE) AND METHODS FOR MAKING THE SAME
    Publication number: 20110165415
    Abstract: A hydrophobic coating having a contact angle of at least about 150 degrees is disclosed herein, which coating comprises: a polymer substrate comprising a first linker incorporated therein at a specified surface density of from about 3×10?4 to about 9×10?8 units per nm2; a first polymer layer in contact with said first linker; a second linker in contact with said first polymer layer; and a second polymer layer in contact with said second linker. Also disclosed herein are methods for producing the hydrophobic coating. This hydrophobic coating is useful for making microfluidic devices having a hydrophobic coating on the microfluidic channels, as well as other uses in the field of microfluidics.
    Type: Application
    Filed: August 11, 2008
    Publication date: July 7, 2011
    Inventors: Hongwei Ma, Tongcheng Qian, Yuanzi Wu