Patents by Inventor Tongcun ZHANG

Tongcun ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210340510
    Abstract: The present invention relates to the field of genetic engineering, particularly to a fumonisin degrading enzyme FumDPS, gene and application thereof. The present invention provides a fumonisin degrading enzyme FumDPS from Pigmentiphaga sp. which has the amino acid sequence of SEQ ID NO: 1, has the optimum temperature of 37° C., and the optimum pH of 8 to 9, remains more than 60% of the activity in the range of pH 3 to 7, and has 100% of degradation rate of fumonisin B1 at the optimum temperature and pH.
    Type: Application
    Filed: September 29, 2019
    Publication date: November 4, 2021
    Inventors: Zhongyuan LI, Tongcun ZHANG, Junqi ZHAO, Huihui LIU
  • Publication number: 20190389940
    Abstract: Relating to immunotherapy of infectious diseases, in particular to construction and application of a recombinant gene for chimeric antigen receptor (CAR) for treating HIV infection, a single-chain antibody ScFv is capable of recognizing gp120 on the surface of an HIV virus-infected cell, which is obtained by tandemly ligating light chain and heavy chain variable regions of an antibody against gp120 on the surface of the HIV virus-infected cell. The single-chain antibody is made into a chimeric antigen receptor (CAR), the CAR encoding gene is transferred into a plasmid vector, and the lentiviral vector into which the CAR encoding gene is transduced is transduced into CD8+ T lymphocytes. The obtained CAR-T lymphocytes have been found to have significant activity in inhibiting and killing HIV-infected cells in both in vitro and in vivo experiments, which can be used as an active ingredient for preparing a drug against HIV infection.
    Type: Application
    Filed: August 28, 2017
    Publication date: December 26, 2019
    Inventors: Tongcun ZHANG, Chaojiang GU, Xinghua LIAO