Patents by Inventor Tongjie Wang
Tongjie Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250129333Abstract: Provided are a RIC cell, and a preparation method therefor and application thereof. The present invention particularly relates to the lineage-specific differentiation of a pluripotent or multipotent stem cell, specifically to a RIC cell differentiated from a stem cell, and a preparation method therefor and application thereof.Type: ApplicationFiled: July 11, 2022Publication date: April 24, 2025Applicants: INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES, BEIJING INSTITUTE FOR STEM CELL AND REGENERATIVE MEDICINEInventors: Jinyong Wang, Dehao HUANG, Jianhuan LI, Fangxiao HU, Tongjie WANG, Chengxiang XIA, Baoyang HU, Jie HAO, Lei WANG, Liu WANG
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Patent number: 11918987Abstract: Provided are a preparation method for a propylene epoxidation catalyst, and a use thereof. During the preparation, an alkoxide solution of a prepared active component and a silica gel support are mixed, then a rotary evaporation treatment is performed on the mixture to remove a low-carbon alcohol to obtain a catalyst precursor, and then the obtained catalyst precursor is subjected to calcination and silylation treatments to obtain the propylene epoxidation catalyst. The catalyst is prepared in a simple process, can be applied to the chemical process of preparing propylene oxide by propylene epoxidation, has high average selectivity to propylene oxide, and has industrial application prospect.Type: GrantFiled: January 14, 2020Date of Patent: March 5, 2024Assignee: Wanhua Chemical Group Co., Ltd.Inventors: Lei Wang, Tongji Wang, Fei Ye, Kang Sun, Naibo Chu, Qiankun Jiao, Yuan Li
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Patent number: 11511260Abstract: The present invention relates to a preparation method for an olefin epoxidation catalyst, comprising: (1) preparing a titanium-silicon gel; (2) performing pore-enlarging treatment to the titanium-silicon gel by using organic amine or liquid ammonia, and drying, calcinating to obtain a titanium-silicon composite oxide; (3) optionally performing alcohol solution of organic alkali metal salt treatment; and (4) optionally performing gas-phase silanization treatment. The catalyst prepared by the method of the present invention has adjustable variability for pore size, so that the activity thereof for epoxidation reactions of the olefin molecules with different dynamic diameters is higher; the surface acidity of the catalyst can be reduced effectively through two-step modification to the catalyst, so that the catalyst has higher selectivity for epoxidation product.Type: GrantFiled: June 29, 2018Date of Patent: November 29, 2022Inventors: Tongji Wang, Fei Ye, Lei Wang, Naibo Chu, Lichao Yang, Kang Sun, Yuan Li, Weiqi Hua
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Publication number: 20220305479Abstract: Provided are a preparation method for a propylene epoxidation catalyst, and a use thereof. During the preparation, an alkoxide solution of a prepared active component and a silica gel support are mixed, then a rotary evaporation treatment is performed on the mixture to remove a low-carbon alcohol to obtain a catalyst precursor, and then the obtained catalyst precursor is subjected to calcination and silylation treatments to obtain the propylene epoxidation catalyst. The catalyst is prepared in a simple process, can be applied to the chemical process of preparing propylene oxide by propylene epoxidation, has high average selectivity to propylene oxide, and has industrial application prospect.Type: ApplicationFiled: January 14, 2020Publication date: September 29, 2022Applicant: Wanhua Chemical Group Co., Ltd.Inventors: Lei WANG, Tongji WANG, Fei YE, Kang SUN, Naibo CHU, Qiankun JIAO, Yuan LI
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Patent number: 11291985Abstract: A preparation method for a propylene epoxidation catalyst: pre-hydrolyzing a silicon source, adding a titanium source and reacting to form a sol, atomizing the sol and then spraying it into liquid ammonia for molding, implementing pore broadening, and performing drying, calcination, and silanization treatment to obtain a Ti—SiO2 composite oxide catalyst. The present catalyst can be used in the chemical process of preparing propylene oxide by epoxidation of propylene, the average propylene oxide selectivity being up to 97.5%, having prospects for industrial application.Type: GrantFiled: June 14, 2018Date of Patent: April 5, 2022Inventors: Lei Wang, Tongji Wang, Fei Ye, Lichao Yang, Guangquan Yi, Jiaoying Cui, Naibo Chu, Yuan Li, Weiqi Hua
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Patent number: 11213811Abstract: Disclosed in the present invention are a preparation method for an olefin epoxidation catalyst and applications thereof. The method comprises: loading an auxiliary metal salt onto a silica gel carrier, and carrying out a drying treatment to the silica gel carrier; loading a titanium salt (preferably TiCl4) onto the silica gel carrier by a chemical vapor deposition method; calcining to obtain a silica gel on which the auxiliary metal oxide and Ti species are loaded; obtaining an catalyst precursor (Ti-MeO—SiO2 composite oxide) by water vapor washing; loading alkyl silicate (preferably tetraethyl orthosilicate) onto the surface of the catalyst precursor by a chemical vapor deposition method and calcining the catalyst precursor to obtain a Ti-MeO—SiO2 composite oxide with the surface coated with a SiO2 layer; and carrying out a silylanization treatment to obtain the catalyst.Type: GrantFiled: May 24, 2018Date of Patent: January 4, 2022Assignee: WANHUA CHEMICAL GROUP CO., LTD.Inventors: Lei Wang, Tongji Wang, Fei Ye, Lichao Yang, Guangquan Yi, Jiaoying Cui, Naibo Chu, Yuan Li, Weiqi Hua
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Publication number: 20210113990Abstract: The present invention relates to a preparation method for an olefin epoxidation catalyst, comprising: (1) preparing a titanium-silicon gel; (2) performing pore-enlarging treatment to the titanium-silicon gel by using organic amine or liquid ammonia, and drying, calcinating to obtain a titanium-silicon composite oxide; (3) optionally performing alcohol solution of organic alkali metal salt treatment; and (4) optionally performing gas-phase silanization treatment. The catalyst prepared by the method of the present invention has adjustable variability for pore size, so that the activity thereof for epoxidation reactions of the olefin molecules with different dynamic diameters is higher; the surface acidity of the catalyst can be reduced effectively through two-step modification to the catalyst, so that the catalyst has higher selectivity for epoxidation product.Type: ApplicationFiled: June 29, 2018Publication date: April 22, 2021Applicant: Wanhua Chemical Group Co., Ltd.Inventors: Tongji Wang, Fei Ye, Lei Wang, Naibo Chu, Lichao Yang, Kang Sun, Yuan Li, Weiqi Hua
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Publication number: 20200269228Abstract: A preparation method for a propylene epoxidation catalyst: pre-hydrolyzing a silicon source, adding a titanium source and reacting to form a sol, atomizing the sol and then spraying it into liquid ammonia for molding, implementing pore broadening, and performing drying, calcination, and silanization treatment to obtain a Ti—SiO2 composite oxide catalyst. The present catalyst can be used in the chemical process of preparing propylene oxide by epoxidation of propylene, the average propylene oxide selectivity being up to 97.5%, having prospects for industrial application.Type: ApplicationFiled: June 14, 2018Publication date: August 27, 2020Applicant: Wanhua Chemical Group Co., Ltd.Inventors: Lei Wang, Tongji Wang, Fei Ye, Lichao Yang, Guangquan Yi, Jiaoying Cui, Naibo Chu, Yuan Li, Weiqi Hua
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Publication number: 20200147599Abstract: Disclosed in the present invention are a preparation method for an olefin epoxidation catalyst and applications thereof. The method comprises: loading an auxiliary metal salt onto a silica gel carrier, and carrying out a drying treatment to the silica gel carrier; loading a titanium salt (preferably TiCl4) onto the silica gel carrier by a chemical vapor deposition method; calcining to obtain a silica gel on which the auxiliary metal oxide and Ti species are loaded; obtaining an catalyst precursor (Ti-MeO—SiO2 composite oxide) by water vapor washing; loading alkyl silicate (preferably tetraethyl orthosilicate) onto the surface of the catalyst precursor by a chemical vapor deposition method and calcining the catalyst precursor to obtain a Ti-MeO—SiO2 composite oxide with the surface coated with a SiO2 layer; and carrying out a silylanization treatment to obtain the catalyst.Type: ApplicationFiled: May 24, 2018Publication date: May 14, 2020Inventors: Lei WANG, Tongji WANG, Fei YE, Lichao YANG, Guangquan YI, Jiaoying CUI, Naibo CHU, Yuan LI, Weiqi HUA
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Patent number: 10493106Abstract: The present invention discloses a method for remolding bone marrow microenvironment in a subject having an impaired bone marrow microenvironment, which comprises implanting a composition comprising isolated mesenchymal stromal cells (MSCs) into the bone marrow cavity of the subject. The method of the present invention successfully remolds the bone marrow microenvironment, recovers the normal hematopoiesis of bone marrow, inhibits/delays the pathological process of leukemia and significantly prolongs the survival period. In addition, the method according to the present invention can be used for the treatment of hematologic tumors such as leukemia and aplastic anemia (AA), which is safe and effective but has no side effects.Type: GrantFiled: January 12, 2018Date of Patent: December 3, 2019Assignee: GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCESInventors: Jinyong Wang, Chengxiang Xia, Yong Dong, Tongjie Wang, Xiaofei Liu, Juan Du, Yang Geng, Lijuan Liu, Hongling Wu
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Publication number: 20190111084Abstract: The present invention discloses a method for remolding bone marrow microenvironment in a subject having an impaired bone marrow microenvironment, which comprises implanting a composition comprising isolated mesenchymal stromal cells (MSCs) into the bone marrow cavity of the subject. The method of the present invention successfully remolds the bone marrow microenvironment, recovers the normal hematopoiesis of bone marrow, inhibits/delays the pathological process of leukemia and significantly prolongs the survival period. In addition, the method according to the present invention can be used for the treatment of hematologic tumors such as leukemia and aplastic anemia (AA), which is safe and effective but has no side effects.Type: ApplicationFiled: January 12, 2018Publication date: April 18, 2019Inventors: Jinyong Wang, Chengxiang Xia, Yong Dong, Tongjie Wang, Xiaofei Liu, Juan Du, Yang Geng, Lijuan Liu, Hongling Wu