Patents by Inventor Tongxiang Lin

Tongxiang Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDUCTION OF PLURIPOTENT CELLS
    Publication number: 20250136948
    Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.
    Type: Application
    Filed: December 5, 2024
    Publication date: May 1, 2025
    Inventors: Tongxiang Lin, Sheng Ding
  • Induction of pluripotent cells
    Patent number: 12195762
    Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: January 14, 2025
    Assignee: The Scripps Research Institute
    Inventors: Tongxiang Lin, Sheng Ding
  • INDUCTION OF PLURIPOTENT CELLS
    Publication number: 20210403878
    Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.
    Type: Application
    Filed: May 14, 2021
    Publication date: December 30, 2021
    Inventors: Tongxiang Lin, Sheng Ding
  • Induction of pluripotent cells
    Patent number: 11046933
    Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 29, 2021
    Assignee: The Scripps Research Institute
    Inventors: Tongxiang Lin, Sheng Ding
  • COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20180171303
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: February 8, 2018
    Publication date: June 21, 2018
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • INDUCTION OF PLURIPOTENT CELLS
    Publication number: 20180163181
    Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.
    Type: Application
    Filed: January 19, 2018
    Publication date: June 14, 2018
    Inventors: Tongxiang Lin, Sheng Ding
  • Combined chemical and genetic approaches for generation of induced pluripotent stem cells
    Patent number: 9926533
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: March 27, 2018
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • Induction of pluripotent cells
    Patent number: 9909105
    Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: March 6, 2018
    Assignee: The Scripps Research Institute
    Inventors: Tongxiang Lin, Sheng Ding
  • CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20180002671
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: August 23, 2017
    Publication date: January 4, 2018
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • Chemical approaches for generation of induced pluripotent stem cells
    Patent number: 9771563
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: September 26, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20170081640
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: November 30, 2016
    Publication date: March 23, 2017
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • Combined chemical and genetic approaches for generation of induced pluripotent stem cells
    Patent number: 9540615
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 10, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • Combined chemical and genetic approaches for generation of induced pluripotent stem cells
    Patent number: 9534205
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: January 3, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20160369244
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 22, 2016
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • Chemical approaches for generation of induced pluripotent stem cells
    Patent number: 9394524
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: July 19, 2016
    Assignee: The Scripps Research Institute
    Inventors: Tongxiang Lin, Wenlin Li, Sheng Ding
  • INDUCTION OF PLURIPOTENT CELLS
    Publication number: 20150240214
    Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.
    Type: Application
    Filed: March 3, 2015
    Publication date: August 27, 2015
    Inventors: Tongxiang Lin, Sheng Ding
  • Induction of pluripotent cells
    Patent number: 9005968
    Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: April 14, 2015
    Assignee: The Scripps Research Institute
    Inventors: Tongxiang Lin, Sheng Ding
  • COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20130273536
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 17, 2013
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • METHODS OF GENERATING PLURIPOTENT STEM CELLS
    Publication number: 20130059385
    Abstract: Disclosed are methods, compositions, and kits of producing an induced pluripotent stem cell from a mammalian non-pluripotent cell that does not endogenously or heterologously express Sox2 and is not in contact with a Sox2 polypeptide.
    Type: Application
    Filed: March 2, 2010
    Publication date: March 7, 2013
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Wenlin Li, Tongxiang Lin, Sheng Ding
  • INDUCTION OF PLURIPOTENT CELLS
    Publication number: 20120264218
    Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.
    Type: Application
    Filed: October 15, 2010
    Publication date: October 18, 2012
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Tongxiang Lin, Sheng Ding