Patents by Inventor Tonia S. AHMED

Tonia S. AHMED has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10995049
    Abstract: The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R1 is defined in the specification
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: May 4, 2021
    Assignee: California Institute of Technology
    Inventors: Jiaming Li, Chen Xu, Tonia S Ahmed, Robert H Grubbs, Brian M. Stoltz
  • Publication number: 20210053043
    Abstract: This invention relates generally to metathesis catalysts and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in Z and E selective olefin metathesis reactions. The invention has utility in the fields of organometallics and organic synthesis.
    Type: Application
    Filed: November 10, 2020
    Publication date: February 25, 2021
    Inventors: Adam M. JOHNS, T. Patrick MONTGOMERY, Tonia S. AHMED, Robert H. GRUBBS, Richard L. PEDERSON
  • Publication number: 20210017111
    Abstract: The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R1 is defined in the specification
    Type: Application
    Filed: July 7, 2020
    Publication date: January 21, 2021
    Inventors: Jiaming Li, Chen Xu, Tonia S. Ahmed, Robert H. Grubbs, Brian M. Stoltz
  • Publication number: 20200385360
    Abstract: This invention relates generally to the synthesis of E-macrocycles using stereoretentive ruthenium olefin metathesis catalysts supported by dithioiate ligands. Macrocycles were generated with excellent selectivity (>99% E) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield) from diene starting materials bearing two E-olefins or bearing one E-olefin and one terminal olefin, A variety of rings were constructed, ranging from 12- to 18-membered macrocycles, including the antibiotic recifeiolide. The invention has utility in the fields of organometallics and organic synthesis.
    Type: Application
    Filed: December 4, 2018
    Publication date: December 10, 2020
    Inventors: Tonia S. AHMED, T. Patrick MONTGOMERY, Robert H. GRUBBS
  • Patent number: 10857530
    Abstract: This invention relates generally to metathesis catalysts and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in Z and E selective olefin metathesis reactions. The invention has utility in the fields of organometallics and organic synthesis.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: December 8, 2020
    Assignees: Umicore AG & Co. KG, California Institute of Technology
    Inventors: Adam M. Johns, T. Patrick Montgomery, Tonia S. Ahmed, Robert H. Grubbs, Richard L. Pederson
  • Publication number: 20200102285
    Abstract: A highly efficient, Z-selective ring-closing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based catalyst supported by a dithiolate ligand is reported. This catalyst is demonstrated to be remarkably active as observed in initiation experiments showing complete catalyst initiation at ?20° C. within 10 min. Using easily accessible diene starting materials bearing a Z-olefin moiety, macrocyclization reactions generated products with significantly higher Z-selectivity in appreciably shorter reaction times, in higher yield, and with much lower catalyst loadings than in previously reported systems. Macrocyclic lactones ranging in size from twelve-membered to seventeen-membered rings are synthesized in moderate to high yields (68-79% yield) with excellent Z-selectivity (95%-99% Z).
    Type: Application
    Filed: April 24, 2018
    Publication date: April 2, 2020
    Inventors: Tonia S. AHMED, Robert H. GRUBBS
  • Publication number: 20180361371
    Abstract: This invention relates generally to metathesis catalysts and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in Z and E selective olefin metathesis reactions. The invention has utility in the fields of organometallics and organic synthesis.
    Type: Application
    Filed: December 9, 2016
    Publication date: December 20, 2018
    Inventors: Adam M. JOHNS, T. Patric MONTGOMERY, Tonia S. AHMED, Robert H. GRUBBS, Richard L. PEDERSON
  • Patent number: 9701704
    Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in (E)-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: July 11, 2017
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Choon Woo Lee, Robert H. Grubbs, Pablo E. Guzman, Tonia S. Ahmed, T. Patrick Montgomery
  • Publication number: 20170022231
    Abstract: This invention relates generally to olefin metathesis catalyst compounds, to the preparation of such compounds, and the use of such catalysts in the metathesis of olefins and olefin compounds, more particularly, in the use of such catalysts in (E)-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.
    Type: Application
    Filed: March 18, 2016
    Publication date: January 26, 2017
    Inventors: Choon Woo LEE, Robert H. GRUBBS, Pablo E. GUZMAN, Tonia S. AHMED, T. Patrick MONTGOMERY