Patents by Inventor Tony A. Klink

Tony A. Klink has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120244549
    Abstract: This invention provides methods to determine the activity of methyltransferase enzymes which employ S-adenosylmethionine (SAM) as a substrate and transfer a methyl group to convert this substrate to S-adenosylhomocysteine (SAH), by measuring SAH conversion to AMP.
    Type: Application
    Filed: March 23, 2012
    Publication date: September 27, 2012
    Applicant: BELLBROOK LABS, LLC
    Inventors: Robert G. Lowery, Matt Staeben, Tony A. Klink
  • Publication number: 20100240080
    Abstract: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.
    Type: Application
    Filed: March 22, 2010
    Publication date: September 23, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Tony A. Klink, Jane A. Beebe, David A. Lasky, Karen M. Kleman-Leyer, Richard Somberg
  • Patent number: 7727752
    Abstract: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: June 1, 2010
    Assignee: Life Technologies Corporation
    Inventors: Tony A. Klink, Jane A. Beebe, David A. Lasky, Karen M. Kleman-Leyer, Richard Somberg
  • Patent number: 7619059
    Abstract: Compositions, methods, and kits for detecting and monitoring post-translational modification activities, including kinase or phosphatase activities, are described. The compositions typically include a peptide, a first detectable moiety, a first binding member, and a protease cleavage site. Modification of a composition by a post-translational modification enzyme, such as a kinase or phosphatase, alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition when it is associated noncovalently with a probe composition that includes a second binding member and a second detectable moiety. Panel assays for determining substrates or modulators of enzymatic activities are also described.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: November 17, 2009
    Assignee: Life Technologies Corporation
    Inventors: Kevin R. Kupcho, Kurt Vogel, Elizabeth A. Werner, Jane A. Beebe, Tony A. Klink, David A. Lasky, Karen M. Kleman-Leyer, Richard Somberg
  • Patent number: 7582461
    Abstract: Compositions, methods, and kits for detecting and monitoring kinase or phosphatase activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase or phosphatase alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase or phosphatase activity are also described.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: September 1, 2009
    Assignee: Life Technologies Corporation
    Inventors: Elizabeth A. Werner, Tony A. Klink, Jane A. Beebe, David A. Lasky, Karen M. Kleman-Leyer, Richard Somberg