Abstract: The present invention provides compositions and methods for treating a tissue disorder associated with a response-to-injury process or proliferating cells in a mammal. The tissue disorders include fibrosis, inflammation, degeneration and invasive disorders such as those occur in cancerous cells. The methods provided herein include administering to the mammal, an effective amount of a composition that alters the activity of transition molecules within a cell. Transition molecules are shown to be comprised of hyaladherins, hyaluronans and associated molecules that regulate the transitional phenotype.

Abstract: Pharmaceutical compositions for treating multiple sclerosis are disclosed comprising an amount of vitamin B12, vitamin B12 analogues, vitamin B12 derivatives, vitamin B12 conjugates or mixtures thereof in combination with interferon. Vitamin B12 or its analogues, derivatives, conjugates or mixtures thereof are administered separately or in combination with interferon to have a synergistic effect resulting in an enhanced therapeutic efficacy for treating multiple sclerosis.

Abstract: Pharmaceutical compositions for treating multiple sclerosis are disclosed comprising an amount of vitamin B12, vitamin B12 analogues, vitamin B12 derivatives, vitamin B12 conjugates or mixtures thereof in combination with interferon-beta. Vitamin B12 or its analogues, derivatives, conjugates or mixtures thereof are administered separately or in combination with interferon-beta to have a synergistic effect resulting in an enhanced therapeutic efficacy for treating multiple sclerosis.