Abstract: A prosthesis for a mammal comprises a prosthesis body (302) with a dorsal surface (311) and a ventral surface (312) shaped to fit in a joint between a tibia and a femur so that the dorsal surface faces a distal end of the femur and the ventral surface faces a proximal end of the tibia. At least one fixation element (303) is provided for fixing the prosthesis body (302) to the tibia (150), wherein the dorsal surface (311) is inclined in a dorsal direction towards a caudal edge of the prosthesis body, to stabilize the femur.

Abstract: A joint prosthesis assembly, includes a joint prosthesis body (1) made of a first biocompatible non-resorbable material and an anchoring element (2-5) made of a second biocompatible non-resorbable material. The anchoring element (2-5) is arranged to allow rotation of an end portion of the joint prosthesis body (1) with respect to the anchoring element (2-5) when in situ.

Abstract: A joint prosthesis assembly, includes a joint prosthesis body (1) made of a first biocompatible non-resorbable material and an anchoring element (2-5) made of a second biocompatible non-resorbable material. The anchoring element (2-5) is arranged to allow rotation of an end portion of the joint prosthesis body (1) with respect to the anchoring element (2-5) when in situ.

Abstract: A self-regulating valve controls the flow of high pressure gas discharging from a gas cylinder in a fire suppression system in response to a detection of a fire within a protected space by a two-step process which reduces the pressure rise within the protected space upon release of the fire suppression gas into the protected space.

Abstract: A self-regulating valve controls the flow of high pressure gas discharging from a gas cylinder in a fire suppression system in response to a detection of a fire within a protected space by a two-step process which reduces the pressure rise within the protected space upon release of the fire suppression gas into the protected space.

Abstract: A two-step, self-regulating valve (16) controls gas flow from a gas cylinder (12) in a high pressure system. The valve (16) includes a valve body (24), a piston (26), a plug (28), a valve actuator (34), and a piston actuator (32). The piston (26) is movable within the valve body (24) along an axis between a first and a second position. The plug (28) is movable within the valve body (24) along the axis between a valve closed position, a partially open position, and a fully open position. The valve actuator (34) allows the plug (28) to move from the valve closed position to the partially open position. The piston actuator (32) causes the piston (26) to move from the first position to the second position when a gas pressure in the gas cylinder (12) is less than a setpoint. When the piston (26) moves to the second position, the piston (26) allows the plug (28) to move from the partially open position to the fully open position.

Abstract: A timing device, for indicating to a user a characteristic of a consumable product related to consumption of the product, comprises a printed circuit integrally supporting a processor, a timer, an indicator and a movement sensor thereon. The movement sensor is arranged to sense motion or vibration of the product relative to its surroundings for determining a user interaction with the product. The processor is operable in one mode so that the indicator indicates expiry of the product responsive to detection of user interaction by the sensor once the time interval of the timer has expired. In another mode, the processor is operable so that the indicator is activated responsive to a dosage interval of the timer being expired. In this later mode, the indicator is deactivated responsive to detection of user interaction by the sensor indicative of a dosage being taken.

Abstract: A two-step, self-regulating valve (16) controls gas flow from a gas cylinder (12) in a high pressure system. The valve (16) includes a valve body (24), a piston (26), a plug (28), a valve actuator (34), and a piston actuator (32). The piston (26) is movable within the valve body (24) along an axis between a first and a second position. The plug (28) is movable within the valve body (24) along the axis between a valve closed position, a partially open position, and a fully open position. The valve actuator (34) allows the plug (28) to move from the valve closed position to the partially open position. The piston actuator (32) causes the piston (26) to move from the first position to the second position when a gas pressure in the gas cylinder (12) is less than a setpoint. When the piston (26) moves to the second position, the piston (26) allows the plug (28) to move from the partially open position to the fully open position.

Abstract: A combination therapy for treating mood disorders, including depressive disorders such as major depression, panic disorder, obsessive compulsive disorder, social anxiety disorder, seasonal affective disorder, and premenstrual dysphoria is provided herein. The combination therapy comprises administering an effettive amount of mecamylamine together with at least one agent for treatment of a mood disorder to a patient in need of treatment of the mood disorder. Pharmaceutical formulations, including packaged pharmaceutical formulations, comprising mecamylamine and an additional agent, such as an SSRI, are also provided herein.

Abstract: An electronic organizer and storage device has a plurality of compartments for storing tablets or capsules, a plurality of preprogrammed prescription cycles, a compliance verification function unit, a prescription cycle verification unit, a multi-color-multi-function indicator for confirming operation functions, a light for each compartment, and an alarm unit, the light unit and the alarm unit being formed so that a light flashes by the light unit adjacent to a corresponding tablet chamber when tablets or capsules are to be taken and at the same time an audible alarm is activated by the alarm unit so as to provide an audible alarm and at the same time visually identify which tablets or capsules to take next; a unit for storing information on missed alarms; a unit for displaying information on missed alarms using a light means and an audible means; and a unit to queue and transfer information on missed alarms to an external computing device.

Abstract: An electronic organizer and storage device has a plurality of compartments for storing tablets or capsules, a plurality of preprogrammed prescription cycles, a compliance verification function unit, a prescription cycle verification unit, a multi-color-multi-function indicator for confirming operation functions, a light for each compartment, and an alarm unit, the light unit and the alarm unit being formed so that a light flashes by the light unit adjacent to a corresponding tablet chamber when tablets or capsules are to be taken and at the same time an audible alarm is activated by the alarm unit so as to provide an audible alarm and at the same time visually identify which tablets or capsules to take next; a unit for storing information on missed alarms; a unit for displaying information on missed alarms using a light means and an audible means; and a unit to queue and transfer information on missed alarms to an external computing device.