Patents by Inventor Tony Godfrey
Tony Godfrey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230002807Abstract: This invention provides ultra-sensitive methods and compositions for detecting patient-specific mutations from cell free nucleic acids (cfDNA) without sequencing. Methods of the invention make use of fluidic partitions for multiplex amplification of cfDNA and thereby create a library of uniformly amplified amplicons. The uniformly amplified amplicons can be split into any number of different detection reactions (while maintaining detection sensitivity) for single-plex detection of mutations present in cfDNA. These methods provide substantially improved signal to noise ratio and easier discrimination of low-abundance mutations.Type: ApplicationFiled: June 29, 2022Publication date: January 5, 2023Inventors: Tony Godfrey, Catherine Kugler, Robert Meltzer
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Patent number: 8993251Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: GrantFiled: December 16, 2011Date of Patent: March 31, 2015Assignees: The Regents of the University of California, The Hospital for Sick ChildrenInventors: Joe W. Gray, Colin Conrad Collins, Soo-In Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Publication number: 20140113978Abstract: The present invention is directed to methods and products for defining a biomarker of disease phenotype. The present invention further relates to methods and kits for determining a subject's risk of developing recurrent hepatocellular carcinoma based on a defined microRNA biomarker that reliably distinguishes hepatocellular carcinoma disease recurrence from non-recurrence. The invention also relates to methods of treating a patient having heptocellular carcinoma based on their risk of developing hepatocellular carcinoma disease recurrence.Type: ApplicationFiled: May 1, 2012Publication date: April 24, 2014Applicant: UNIVERSITY OF ROCHESTERInventors: Christopher Barry, Tony Godfrey, Anthony Almudevar
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Publication number: 20130095475Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: ApplicationFiled: December 16, 2011Publication date: April 18, 2013Applicants: THE HOSPITAL FOR SICK CHILDREN, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Joe W. Gray, Colin Conrad Collins, Soo-In Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Patent number: 8101370Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: GrantFiled: May 27, 2008Date of Patent: January 24, 2012Assignees: The Regents of the University of California, The Hospital for Sick ChildrenInventors: Joe W. Gray, Colin Conrad Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Patent number: 7811986Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: GrantFiled: July 22, 2008Date of Patent: October 12, 2010Assignees: The Regents of The University of California, The Hospital for Sick ChildrenInventors: Joe W. Gray, Colin Conrad Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Publication number: 20090155789Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: ApplicationFiled: May 27, 2008Publication date: June 18, 2009Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE HOSPITAL FOR SICK CHILDRENInventors: Joe W. Gray, Colin Conrad Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Publication number: 20090081672Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: ApplicationFiled: July 22, 2008Publication date: March 26, 2009Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE HOSPITAL FOR SICK CHILDRENInventors: Joe W. Gray, Colin Conrad Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Patent number: 7455964Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: GrantFiled: January 17, 1997Date of Patent: November 25, 2008Assignees: The Hospital for Sick Children, The Regents of the University of CaliforniaInventors: Joe W. Gray, Colin Conrad Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Patent number: 7413899Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: GrantFiled: February 6, 2006Date of Patent: August 19, 2008Assignees: The Hospital for Sick Children, The Regents of the University of CaliforniaInventors: Joe W Gray, Colin Conrad Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Publication number: 20060292591Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: ApplicationFiled: February 6, 2006Publication date: December 28, 2006Inventors: Joe Gray, Colin Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Publication number: 20060205006Abstract: A method for balancing multiplexed PCR methods is provided. In the method, two or more sequential temporal PCR stages are used to effectively separate two or more PCR reactions in a single tube as an alternative to primer limiting to modulate the relative rate of production of a first amplicon by a first primer set and a second amplicon by a second primer set during the first and second amplification stages. Also provided are rapid RT-PCR methods that find particular use in intraoperative diagnoses and prognoses, for instance in diagnosing malignant esophageal adenocarcenoma by determining expression levels of carcinoembryonic antigen (CEA) in sentinel lymph nodes.Type: ApplicationFiled: May 12, 2006Publication date: September 14, 2006Inventors: Tony Godfrey, James Luketich, Siva Raja, Lori Kelly, Sydney Finkelstein
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Patent number: 7049424Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: GrantFiled: October 16, 1996Date of Patent: May 23, 2006Assignee: The Regents of the University of CaliforniaInventors: Joe W. Gray, Colin Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Publication number: 20060068433Abstract: Methods for balancing multiplexed PCR reactions are provided which exploit differences in primer and amplicon Tms. The methods may be controlled by a computer process. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.Type: ApplicationFiled: September 20, 2005Publication date: March 30, 2006Inventors: Tony Godfrey, William McMillan
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Publication number: 20060068418Abstract: Methods for identifying expression of markers indicative of the presence of breast cancer and lung cancer are provided. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.Type: ApplicationFiled: July 8, 2005Publication date: March 30, 2006Inventors: Tony Godfrey, Liqiang Xi, Siva Raja, William Gooding
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Publication number: 20060019290Abstract: Methods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.Type: ApplicationFiled: July 8, 2005Publication date: January 26, 2006Inventors: Tony Godfrey, Liqiang Xi, Siva Raja, Steven Hughes, William Gooding
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Patent number: 6808878Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: GrantFiled: July 15, 1997Date of Patent: October 26, 2004Assignees: The Regents of the University of California, The Hospital for Sick ChildrenInventors: Joe W. Gray, Colin Conrad Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Publication number: 20030148270Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: ApplicationFiled: October 16, 1996Publication date: August 7, 2003Inventors: JOE W. GRAY, COLIN COLLINS, SOO-IN HWANG, TONY GODFREY, DAVID KOWBEL, JOHANNA ROMMENS
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Patent number: 5892010Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.Type: GrantFiled: July 15, 1996Date of Patent: April 6, 1999Assignees: The Regents of the University of California, The Hospital for Sick ChildrenInventors: Joe Gray, Colin Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens