Abstract: The present disclosure relates to the biopharmaceutical field, in particular, Exatecan derivatives, linker-payloads, and conjugates and thereof antibody-drug conjugates, and the corresponding preparing process and use thereof.

Abstract: Method and system for detecting disease in blood sample is described. By extracting extracellular vesicles (EVs) from the blood sample and employing liposome fusion probes, it is shown that the test can be completed within hours instead of weeks, and the detection limit can be significantly lowered.

Abstract: This disclosure describes a method and system for active machine learning model that automatically and continuously improve the model with high accuracy, sensitivity, specificity and universality.

Abstract: A method and system for detecting TB in a bodily fluid sample are described. By extracting extracellular vesicles (EVs) from the bodily fluid sample and employing antibody-conjugated nanoparticles to capture Mtb-related biomarkers, it is shown that the test can be completed within hours instead of weeks, and the detection limit can be significantly lowered with high accuracy. Additionally, the method and system described is capable of distinguishing between active and latent TB infections.

Abstract: An online educational system includes a load balancing reverse proxy server adapted to receive requests from a plurality of student clients and institution clients; a platform coupled to the server, the platform comprising supporting services including tuition and fee payment management, identity and role management, student application status management services; an analytical data warehouse and databases coupled to the platform; a data warehouse coupled to the analytical data warehouse; and a machine learning network coupled to the data warehouse to generate educational recommendations to help students learn.

Abstract: Crystalline molecular framework:small molecule compounds. The molecular framework is formed from guanidinium cations and organosulfonate anions and the guanidinium cations and organosulfonate anions are associated via one or more hydrogen bond. The small molecule(s) is/are encapsulated by the molecular framework. Methods for making crystalline molecular framework:small molecule compounds may include combining guanidinium cations, organosulfonate anions, and small molecules in a single step. The crystalline molecular framework:small molecule compounds can be used to determine the structure of the small molecule(s).

Abstract: A system and method for an automatic transfer switch comprising a fixed contact (26), a first oscillating rod (16) communicatively and operatively connected to a first movable contact (25), a second oscillating rod (18) communicatively and operatively connected to a second movable contact (27), a link rod (12) communicatively and operable connected to the first and second oscillating rods (16, 18), a guide plate (20), and a permanent magnetic actuator (2) comprising a first end and a second end communicatively and operatively connected to the link rod (12) via a third oscillating rod (8), wherein the first end being energized independently of the second end. The automatic transfer switch is operable to position the guide plate (20) based at least on a permanent magnetic force applied to the first end or the second end of the permanent magnetic actuator.

Abstract: Crystalline molecular framework:small molecule compounds. The molecular framework is formed from guanidinium cations and organosulfonate anions and the guanidinium cations and organosulfonate anions are associated via one or more hydrogen bond. The small molecule(s) is/are encapsulated by the molecular framework. Methods for making crystalline molecular framework:small molecule compounds may include combining guanidinium cations, organosulfonate anions, and small molecules in a single step. The crystalline molecular framework:small molecule compounds can be used to determine the structure of the small molecule(s).

Abstract: A storage assembly comprises a first cover having a first foot portion, a second cover having a second cover and a housing. The housing includes a first rail extending at a height direction and having a first end, a second rail extending at the height direction and having a second end, and a cavity forming a storage space. The first cover is moveable between a first stowed position and a first middle position when the first foot portion moves in the first rail, and pivotable via the first end from the first middle position to a first use position to cover the cavity, and the second cover is moveable between a second stowed position and a second middle position when the second foot portion moves in the second rail, and pivotable via the second end from the second middle position to a second use position to cover the cavity.

Abstract: A storage assembly comprises a first cover having a first foot portion, a second cover having a second cover and a housing. The housing includes a first rail extending at a height direction and having a first end, a second rail extending at the height direction and having a second end, and a cavity forming a storage space. The first cover is moveable between a first stowed position and a first middle position when the first foot portion moves in the first rail, and pivotable via the first end from the first middle position to a first use position to cover the cavity, and the second cover is moveable between a second stowed position and a second middle position when the second foot portion moves in the second rail, and pivotable via the second end from the second middle position to a second use position to cover the cavity.

Abstract: A system and method for an automatic transfer switch comprising a fixed contact, a first oscillating rod communicatively and operatively connected to a first movable contact, a second oscillating rod communicatively and operatively connected to a second movable contact, a link rod communicatively and operable connected to the first and second oscillating rods, and a guide plate. The automatic transfer switch is operable to position the guide plate based at least on a state of a solenoid. A permanent magnetic actuator communicatively and operatively connected to the link rod via a third oscillating rod is operable to rotate the first oscillating rod or the second oscillating rod based at least on the position of the guide plate.

Abstract: A system and method for an automatic transfer switch comprising a fixed contact (26), a first oscillating rod (16) communicatively and operatively connected to a first movable contact (25), a second oscillating rod (18) communicatively and operatively connected to a second movable contact (27), a link rod (12) communicatively and operable connected to the first and second oscillating rods (16, 18), a guide plate (20), and a permanent magnetic actuator (2) comprising a first end and a second end communicatively and operatively connected to the link rod (12) via a third oscillating rod (8), wherein the first end being energized independently of the second end. The automatic transfer switch is operable to position the guide plate (20) based at least on a permanent magnetic force applied to the first end or the second end of the permanent magnetic actuator.

Abstract: A system and method for an automatic transfer switch comprising a fixed contact, a first oscillating rod communicatively and operatively connected to a first movable contact, a second oscillating rod communicatively and operatively connected to a second movable contact, a link rod communicatively and operable connected to the first and second oscillating rods, and a guide plate. The automatic transfer switch is operable to position the guide plate based at least on a state of a solenoid. A permanent magnetic actuator communicatively and operatively connected to the link rod via a third oscillating rod is operable to rotate the first oscillating rod or the second oscillating rod based at least on the position of the guide plate.

Abstract: A method for detecting hepcidin. Having a sample liquid in contact with a nanochip having a specific surface coating structure of silicon oxide, so that hepcidin is enriched with specificity; eluting the nanochip with an eluent; by performing mass spectrometric detection on the elution product, determining the hepcidin content in the elution product. The enrichment method substantially enhances the sensitivity and accuracy of mass spectrometric detection. A kit for detecting hepcidin comprising a sample diluent and a nanochip, the sample diluent comprising water, trifluoroacetic acid, and acetonitrile.

Abstract: A method for detecting hepcidin. Having a sample liquid in contact with a nanochip having a specific surface coating structure of silicon oxide, so that hepcidin is enriched with specificity; eluting the nanochip with an eluent; by performing mass spectrometric detection on the elution product, determining the hepcidin content in the elution product. The enrichment method substantially enhances the sensitivity and accuracy of mass spectrometric detection. A kit for detecting hepcidin comprising a sample diluent and a nanochip, the sample diluent comprising water, trifluoroacetic acid, and acetonitrile.

Abstract: A variable flow infant feeding assembly is designed so that a caregiver can select an optimal feeding flow rate without having to change nipples, as may be desired depending upon the age and appetite of the infant as well as the liquid that is being dispensed. Preferably, the assembly includes a baby bottle and a nipple member that has ventilation structure defined therein for permitting replacement air to enter the baby bottle during feeding. Retention structure such as a threaded ring member is provided for securing the nipple member to the baby bottle. Advantageously, variable restrictor structure is provided, preferably so as to be integral with the ring member, for selectively blocking at least a portion of the ventilation structure. By controlling the size of the opening through which replacement air flows into the baby bottle, the variable restrictor structure permits the feeding flow rate through the nipple member to be adjusted by a caregiver.

Abstract: A variable flow infant feeding assembly is designed so that a caregiver can select an optimal feeding flow rate without having to change nipples, as may be desired depending upon the age and appetite of the infant as well as the liquid that is being dispensed. Preferably, the assembly includes a baby bottle and a nipple member that has ventilation structure defined therein for permitting replacement air to enter the baby bottle during feeding. Retention structure such as a threaded ring member is provided for securing the nipple member to the baby bottle. Advantageously, variable restrictor structure is provided, preferably so as to be integral with the ring member, for selectively blocking at least a portion of the ventilation structure. By controlling the size of the opening through which replacement air flows into the baby bottle, the variable restrictor structure permits the feeding flow rate through the nipple member to be adjusted by a caregiver.