Patents by Inventor Tony Hung
Tony Hung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11724237Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc.Type: GrantFiled: May 16, 2022Date of Patent: August 15, 2023Assignee: President and Fellows of Harvard CollegeInventors: David A. Weitz, Adam R. Abate, Tony Hung, Pascaline Mary
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Publication number: 20220274072Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc.Type: ApplicationFiled: May 16, 2022Publication date: September 1, 2022Applicant: President and Fellows of Harvard CollegeInventors: David A. Weitz, Adam R. Abate, Tony Hung, Pascaline Mary
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Patent number: 11358105Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc.Type: GrantFiled: January 11, 2021Date of Patent: June 14, 2022Assignee: President and Fellows of Harvard CollegeInventors: David A. Weitz, Adam R. Abate, Tony Hung, Pascaline Mary
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Publication number: 20210197146Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc.Type: ApplicationFiled: January 11, 2021Publication date: July 1, 2021Applicant: President and Fellows of Harvard CollegeInventors: David A. Weitz, Adam R. Abate, Tony Hung, Pascaline Mary
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Patent number: 10962563Abstract: Methods and systems are provided for measuring a velocity of a droplet passing through a microfluidic channel.Type: GrantFiled: January 11, 2019Date of Patent: March 30, 2021Assignee: Bio-Rad Laboratories, Inc.Inventors: Aaron Weber, Tony Hung, Sepehr Kiani
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Patent number: 10919008Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc.Type: GrantFiled: July 25, 2017Date of Patent: February 16, 2021Assignee: President and Fellows of Harvard CollegeInventors: David A. Weitz, Adam R. Abate, Tony Hung, Pascaline Mary
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Patent number: 10730045Abstract: The present invention generally pertains to a system for performing droplet inflation, and methods and kits comprising the same. The system comprises at least one microfluidic channel comprising one or more droplets flowing therein, one or more fluid reservoirs, one or more inflators, one or more inflator nozzles, and at least one mechanism for disrupting an interface between a droplet and a fluid. The present invention provides for the inflation of a relatively controlled volume of fluid into a droplet resulting in an increase in the volume of the droplet relative to its volume prior to inflation and, accordingly, dilution of the concentration of species, if any, previously present and emulsified in the droplet.Type: GrantFiled: November 20, 2018Date of Patent: August 4, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: Tony Hung, Adnan Esmail, Sepehr Kiani
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Patent number: 10633701Abstract: The present invention relates to systems and methods for sequencing nucleic acids, including sequencing nucleic acids in fluidic droplets. In one set of embodiments, the method employs sequencing by hybridization using droplets such as microfluidic droplets. In some embodiments, droplets are formed which include a target nucleic acid, a nucleic acid probe, and at least one identification element, such as a fluorescent particle. The nucleic acid probes that hybridize to the target nucleic acid are determined, in some instances, by determining the at least one identification element. The nucleic acid probes that hybridize to the target nucleic acid may be used to determine the sequence of the target nucleic acid. In certain instances, the microfluidic droplets are provided with reagents that modify the nucleic acid probe. In some cases, a droplet, such as those described above, is deformed such that the components of the droplets individually pass a target area.Type: GrantFiled: August 7, 2017Date of Patent: April 28, 2020Assignee: President and Fellows of Harvard CollegeInventors: David A. Weitz, Jeremy Agresti, Michael P. Weiner, Adam R. Abate, Tony Hung
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Patent number: 10589274Abstract: Methods and systems for manipulating drops in microfluidic channels are provided.Type: GrantFiled: May 22, 2018Date of Patent: March 17, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: Sepehr Kiani, Joshua Blouwolff, Adnan Esmail, Jason Hung, Tony Hung, Adam R. Abate, Scott Powers, Pascaline Mary
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Patent number: 10569268Abstract: The present invention generally pertains to a system for performing injection of multiple substantially controlled volumes into or out of a droplet, and methods and kits comprising the same. The system of the present invention comprises at least one microfluidic channel, one or more injection channels, an injection inlet associated with each of the one or more injection channels, and a mechanism for disrupting an interface between a droplet and a fluid and/or emulsion, wherein the at least one microfluidic channel comprises one or more droplets are flowing therein, and wherein each of the one or more injection channels comprises at least one fluid and/or emulsion therein.Type: GrantFiled: November 27, 2017Date of Patent: February 25, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: Adam Abate, Sepehr Kiani, Tony Hung, Pascaline Mary, Adnan Moez Esmail
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Patent number: 10343167Abstract: The present invention provides a microfluidic system, method and kit for performing assays. The system may comprise a microfluidic device and a detector, wherein the assay yields results that may be read by a detector and analyzed by the system. The assay may comprise one or more chemical or biological reaction against, or performed on, a sample or multiple samples. The sample(s) may become larger and/or smaller during the performance of the assay. The sample(s) may be present within a vehicle, or on a carrier within a vehicle, in the microfluidic device, and wherein the vehicle may become larger and/or smaller during the performance of the assay. The assay may be a cascading assay comprising a series of multiple assays, wherein each assay may be the same or different, and wherein each assay in the series of multiple assays may further comprise one or more process or step.Type: GrantFiled: August 30, 2017Date of Patent: July 9, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Adnan Esmail, Tal Raz, John Healy, Tony Hung, Sepehr Kiani, Pascaline Mary
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Publication number: 20190146002Abstract: Methods and systems are provided for measuring a velocity of a droplet passing through a microfluidic channel.Type: ApplicationFiled: January 11, 2019Publication date: May 16, 2019Inventors: Aaron WEBER, Tony HUNG, Sepehr KIANI
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Publication number: 20190091685Abstract: The present invention generally pertains to a system for performing droplet inflation, and methods and kits comprising the same. The system comprises at least one microfluidic channel comprising one or more droplets flowing therein, one or more fluid reservoirs, one or more inflators, one or more inflator nozzles, and at least one mechanism for disrupting an interface between a droplet and a fluid. The present invention provides for the inflation of a relatively controlled volume of fluid into a droplet resulting in an increase in the volume of the droplet relative to its volume prior to inflation and, accordingly, dilution of the concentration of species, if any, previously present and emulsified in the droplet.Type: ApplicationFiled: November 20, 2018Publication date: March 28, 2019Inventors: Tony HUNG, Adnan ESMAIL, Sepehr KIANI
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Patent number: 10215771Abstract: Methods and systems are provided for measuring a velocity of a droplet passing through a microfluidic channel.Type: GrantFiled: November 4, 2015Date of Patent: February 26, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Aaron Weber, Tony Hung, Sepehr Kiani
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Publication number: 20180369818Abstract: Methods and systems for manipulating drops in microfluidic channels are provided.Type: ApplicationFiled: May 22, 2018Publication date: December 27, 2018Inventors: Sepehr KIANI, Joshua BLOUWOLFF, Adnan ESMAIL, Jason HUNG, Tony HUNG, Adam R. ABATE, Scott POWERS, Pascaline MARY
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Patent number: 10159977Abstract: The present invention generally pertains to a system for performing droplet inflation, and methods and kits comprising the same. The system comprises at least one microfluidic channel comprising one or more droplets flowing therein, one or more fluid reservoirs, one or more inflators, one or more inflator nozzles, and at least one mechanism for disrupting an interface between a droplet and a fluid. The present invention provides for the inflation of a relatively controlled volume of fluid into a droplet resulting in an increase in the volume of the droplet relative to its volume prior to inflation and, accordingly, dilution of the concentration of species, if any, previously present and emulsified in the droplet.Type: GrantFiled: January 20, 2017Date of Patent: December 25, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Tony Hung, Adnan Esmail, Sepehr Kiani
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Patent number: 10130950Abstract: Systems and methods for confining droplets within a microfluidic channel as well as systems and methods for packing droplets are provided. More specifically, a system and method are provided for controlling the introduction and removal of oil into a microfluidic channel in order to control where drops are allowed to flow within that channel.Type: GrantFiled: November 25, 2014Date of Patent: November 20, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Tony Hung, Sepehr Kiani, Scott Powers, Adnan Esmail
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Patent number: 10022721Abstract: Methods and systems for manipulating drops in microfluidic channels are provided.Type: GrantFiled: August 27, 2014Date of Patent: July 17, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Sepehr Kiani, Joshua Blouwolff, Adnan Esmail, Jason Hung, Tony Hung, Adam R. Abate, Scott Powers, Pascaline Mary
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Patent number: 10012592Abstract: The present invention generally pertains to methods and kits for managing the variation in spectroscopic intensity measurements through the use of a reference component. The reference component may comprise a reference spectroscopic substance and may be contained together with a sample of interest in a sample to be tested, wherein the sample of interest may comprise a sample spectroscopic substance. Each sample to be tested may be uniquely identified and, hence, “barcoded” by combinations of different colors and concentrations of spectroscopic substances, contained therein.Type: GrantFiled: October 2, 2017Date of Patent: July 3, 2018Assignee: Bio-Rad Laboratories, Inc.Inventors: Adam Abate, John Lawrence Emhoff, Tony Hung, Adnan Moez Esmail, Sepehr Kiani, Pascaline Mary
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Publication number: 20180078933Abstract: The present invention generally pertains to a system for performing injection of multiple substantially controlled volumes into or out of a droplet, and methods and kits comprising the same. The system of the present invention comprises at least one microfluidic channel, one or more injection channels, an injection inlet associated with each of the one or more injection channels, and a mechanism for disrupting an interface between a droplet and a fluid and/or emulsion, wherein the at least one microfluidic channel comprises one or more droplets are flowing therein, and wherein each of the one or more injection channels comprises at least one fluid and/or emulsion therein.Type: ApplicationFiled: November 27, 2017Publication date: March 22, 2018Inventors: Adam ABATE, Sepehr KIANI, Tony HUNG, Pascaline MARY, Adnan Moez ESMAIL