Abstract: The present invention provides an ?-selective glycosylation method. The ?-selective glycosylation method includes performing a reaction of a donor having a saccharide structure and a formamide-containing compound to form a glycosyl imidate compound; and in one pot environment, performing an addition reaction of the glycosyl imidate compound and an acceptor having a hydroxyl group to form an ?-glycoside with high ?-selectivity. The ?-selective glycosylation method is applicable to the large scale production and easy to recover the formamide-containing compound.

Abstract: A coffin includes a coffin main body; the coffin main body includes an upper frame, a lower frame, a wall and a first cover. The first cover includes a first outward cover and a first cover frame, which is located on the upper frame and connected to the coffin main body. The wall includes two long walls, two short walls, and a bottom wall. The two long walls and two short walls are connected and surround the upper frame and lower frame, and the bottom wall is located on the lower frame, allowing the bottom wall, two long walls and two short walls to form a container. The first outward cover, two long walls, and bottom wall are made of cardboard which is honeycomb cardboard; the first cover frame, the upper frame, and the lower frame are made of wood.

Abstract: Methods and compositions for the treatment of toxin-mediated diseases are provided herein. One aspect of the invention is oligosaccharide-based therapeutics that interact with toxins and methods of uses thereof. In one embodiment the oligosaccharide-based therapeutics of the invention comprise polymeric particles with attached oligosaccharide binding moieties. The compositions of the invention can be used in the treatment of toxin-mediated diseases such as antibiotic-associated diarrhea and pseudomembranous colitis, including Clostridium difficile associated diarrhea.

Abstract: Methods and compositions for the treatment of toxin-mediated diseases are provided herein. One aspect of the invention is oligosaccharide-based therapeutics that interact with toxins and methods of uses thereof. In one embodiment the oligosaccharide-based therapeutics of the invention comprise polymeric particles with attached oligosaccharide binding moieties. The compositions of the invention can be used in the treatment of toxin-mediated diseases such as antibiotic-associated diarrhea and pseudomembranous colitis, including Clostridium difficile associated diarrhea.