Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A system including multiple Channel Heat Exchangers may be used in a minimum of two separate heat exchangers that may be alternated between a hot storage mode and a cold storage mode. The combination of the hot storage mode and cold storage mode creates a synergy, specifically providing greatly increased heat recovery, greatly increased heating and cold storage and greatly increased energy efficiency by combining the two modes with ancillary equipment.

Abstract: A direct heat exchange system uniformly transfers heat through a multiphase substance, such as a refrigerant, to a barrier that emits heat radiantly and convectively. The system solely uses the multiphase substance to exchange heat between the multiphase substance and the barrier. No intermediary fluids are used. A heat exchange portion, such as a heat pump, absorbs and emits heat and transfers it to the multiphase substance. A tube portion carries the multiphase substance to the barrier. The heat is directly exchanged between the tube and the barrier. The barrier emits radiant heat or absorbs heat. A tube fastener fastens the tube to the barrier. A thermal mass portion stores heat behind the barrier. A dehumidification coil helps prevent indoor condensation and tempers the temperature of the air proximal to the barrier by drying the air. A decorative panel covers the tube portion and the thermal mass portion.

Abstract: A method provides a guest access to a defined space selectively accessible through an automated gate. The method includes the steps of causing a resident interface to be displayed to a resident via a resident data device. Guest data is received from the resident about the guest using the resident data device. The guest data is transmitted to a central station. The guest identifies when the guest arrives at the automated gate. The method also opens the automated gate to allow the guest to travel into the defined space after the automated gate is opened.

Abstract: A method provides a guest access to a defined space selectively accessible through an automated gate. The method includes the steps of causing a resident interface to be displayed to a resident via a resident data device. Guest data is received from the resident about the guest using the resident data device. The guest data is transmitted to a central station. The guest identifies when the guest arrives at the automated gate. The method also opens the automated gate to allow the guest to travel into the defined space after the automated gate is opened.

Abstract: A direct heat exchange system uniformly transfers heat through a multiphase substance, such as a refrigerant, to a barrier that emits heat radiantly and convectively. The system solely uses the multiphase substance to exchange heat between the multiphase substance and the barrier. No intermediary fluids are used. A heat exchange portion, such as a heat pump, absorbs and emits heat and transfers it to the multiphase substance. A tube portion carries the multiphase substance to the barrier. The heat is directly exchanged between the tube and the barrier. The barrier emits radiant heat or absorbs heat. A tube fastener fastens the tube to the barrier. A thermal mass portion stores heat behind the barrier. A dehumidification coil helps prevent indoor condensation and tempers the temperature of the air proximal to the barrier by drying the air. A decorative panel covers the tube portion and the thermal mass portion.