Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: An infrared energy detection apparatus having a first array of infrared detectors adapted to detect infrared energy of a first wavelength and produce an electrical signal corresponding to such detected energy, and a second array of infrared detectors, positioned to intercept infrared energy passing through the first array, and adapted to detect energy of a second wavelength in such intercepted energy and produce an electrical signal corresponding to such detected energy. The first array of infrared detectors includes an array of detector devices formed along a lower portion thereof adapted to detect a portion of radiation impinging on the upper portion thereof and, electronic circuitry disposed between the upper and lower portions and connected to the detector devices for producing electrical signals representative of the detected energy having the first wavelength.