Abstract: A self-injection syringe includes an injection button, a syringe body, a needle, and a non-slip surface attached to the syringe body. The non-slip surface may be either formed into the surface of the syringe body, or may be a hook-and-eye fastener material of the Velcro type. In one version of this invention, non-slip surface is confined to a narrow strip disposed lengthwise along the syringe body, so that it falls under the fingers of the user when wrapped around the body. This invention is especially useful when the syringe is of the type in the form of a pen, which contains a cartridge of medication within a cartridge holder, with the cartridge containing enough medication for a number of injections. In this configuration, the syringe has a removable cap and pocket clip, for ease of carrying.