Patents by Inventor Tony Verbeuren
Tony Verbeuren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6686358Abstract: A compound of formula (I): wherein: R1 represents hydrogen, or linear or branched (C1-C6)alkyl optionally substituted by one or more identical or different groups selected from aryl, heteroaryl, cycloalkyl and heterocycloalkyl, represents a saturated ring having from 4 to 7 ring members that may contain, in addition to nitrogen, one or two hetero atoms selected from O, S and —NR3 groups, wherein R3 represents hydrogen or linear or branched (C1-C6)alkyl, n represents an integer such that 1≦n≦6, R2 represents any one of the groups described in the description, their isomers and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as inhibitor of trypsin-related serine proteases and thrombin.Type: GrantFiled: December 14, 2001Date of Patent: February 3, 2004Assignee: Les Laboratoires ServierInventors: Guillaume De Nanteuil, Philippe Gloanec, Tony Verbeuren, Alain Rupin, Marie-Odile Vallez
-
Patent number: 6589956Abstract: A compound of formula (I): wherein: Ra represents a hydroxy, alkoxy, aryloxy or arylalkyloxy group, A represents a CH group or a nitrogen atom, in which case R1 is as defined in the description, or R1—A together represent an oxygen atom or a group, wherein R3 and R4 are as defined in the description, R2 being a hydrogen atom or an alkyl group, Rb and Rc, which may be identical or different, each represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, a hydroxy group or a trihaloalkyl group, n is an integer of from 2 to 6 inclusive, m and p are integers of from 0 to 6 inclusive, its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful as a TXA2 receptor antagonist and 5-HT2 receptor antagonist.Type: GrantFiled: July 12, 2002Date of Patent: July 8, 2003Assignee: Les Laboratoires ServierInventors: Gilbert Lavielle, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Christine Vayssettes-Courchay
-
Publication number: 20030109533Abstract: A compound of formula (I): 1Type: ApplicationFiled: July 12, 2002Publication date: June 12, 2003Inventors: Gilbert Lavielle, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Christine Vayssettes-Courchay
-
Patent number: 6545037Abstract: A compound of formula (I): which is useful as a TXA2 and 5-HT2 receptor and pharmaceutical compositions containing the same.Type: GrantFiled: March 14, 2002Date of Patent: April 8, 2003Assignee: Les Laboratoires ServierInventors: Gilbert Lavielle, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Jean-Jacques Descombes
-
Patent number: 6541471Abstract: A compound of formula (I): wherein: G represents a group such as: wherein R1 and R2 independently represent a hydrogen atom or an alkyl, cycloalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl or heteroarylalkyl group, or, R1 and R2 together with the nitrogen atom form a heterocycloalkyl group, R3 represents a hydrogen atom or an alkyl or optionally substituted phenyl group, Ra represents a hydroxy group, a linear or branched (C1-C6)alkoxy group or an amino group, Rb and Rc, which may be identical or different, each represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, a hydroxy group or a trihaloalkyl group, m is an integer of from 0 to 1 inclusive, n and q are integers of from 0 to 6 inclusive, p and r are integers of from 1 to 6 inclusive, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base; and medicinal products containing the same which are useful as a TXA2 receptType: GrantFiled: July 12, 2002Date of Patent: April 1, 2003Assignee: Les Laboratoires ServierInventors: Gilbert Lavielle, Thierry Dubuffet, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Christine Vayssettes-Courchay
-
Patent number: 6469011Abstract: Compound of formula (I): which is useful as a TXA2 and 5-HT2 receptor antagonist and pharmaceutical compositions containing the same.Type: GrantFiled: January 18, 2001Date of Patent: October 22, 2002Assignee: Les Laboratoires ServierInventors: Gilbert Lavielle, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Jean-Jacques Descombes
-
Publication number: 20020137742Abstract: Compound of formula (I): 1Type: ApplicationFiled: March 14, 2002Publication date: September 26, 2002Inventors: Gilbert Lavielle, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Jean-Jacques Descombes
-
Publication number: 20020111341Abstract: 1Type: ApplicationFiled: December 14, 2001Publication date: August 15, 2002Inventors: Guillaume DE Nanteuil, Philippe Gloanec, Tony Verbeuren, Alain Rupin, Marie-Odile Vallez
-
Patent number: 6302837Abstract: A compound selected from those of formula (I): wherein: X represents oxygen, sulphur, or NR3 wherein R3 is as defined in the description, Y represents oxygen, sulphur, NR3, or may represent single bond in certain cases, T represents nitrogen, carbon, or CH, A represents single bond, alkylene, arylene, cycloalkylene, heterocycloalkylene, heteroarylene, or —SO2—R4— wherein R4 is as defined in the description, W represents hydroxy, alkoxy, aryloxy, arylalkoxy, cycloalkyloxy, heterocycloalkyloxy or heteroaryloxy, or hydroxyamino, U1 represents hetero, or alkylene wherein one or more of carbon may optionally be replaced by one or more hetero atoms, V1 represents arylene, heteroarylene,or heterocycloalkylene, U2 represents single bond, hetero or alkylene wherein one or more carbon may optionally be replaced by one or more hetero atoms, V2 represents aryl, heteroaryl, or heterocycloalkyl, Ra, Rb, Rc, which may be identical or different, each independently of the others rType: GrantFiled: October 13, 2000Date of Patent: October 16, 2001Assignee: Adir et CompagnieInventors: Guillaume De Nanteuil, Christine Lila, Tony Verbeuren, Alain Rupin
-
Patent number: 6288077Abstract: Compound of formula (I): wherein: n represents 2 or 3, R1 represents optionally substituted alkyl, cycloalkyl or optionally substituted phenyl, R2 represents amino, optionally substituted amidino, optionally substituted guanidino or optionally substituted isothioureido, Ar represents aryl or heteroaryl, X1 represents hydroxy or optionally substituted amino, isomers thereof, and also salts thereof with a pharmaceutically acceptable acid or base, and which medicinal products containing the same/are useful as trypsin-related serine protease inhibitors.Type: GrantFiled: May 2, 2000Date of Patent: September 11, 2001Assignee: Adir et CompagnieInventors: Guillaume De Nanteuil, Philippe Gloanec, Tony Verbeuren, Alain Rupin
-
Patent number: 6277851Abstract: A compound selected from those of formula (I): wherein: R1 represents hydrogen, optionally substituted alkyl, cycloalkyl or heterocycloalkyl or a group of formula (G): wherein A1 represents single, —CH2—, —CH2—CH2— or —N(CH3)— or oxygen or sulphur, and X1 and X2, which may be identical or different, each represent carbon or nitrogen, R represents hydrogen or linear or branched (C1-C6)alkyl, represents a saturated ring having from 4 to 7 ring members, n represents integer wherein 1≦n≦6, Ar represents aryl or heteroaryl, its isomers, N-oxydes and pharmaceutically-acceptable acid or base addition salts thereof.Type: GrantFiled: June 15, 2000Date of Patent: August 21, 2001Assignee: Adir et CompagnieInventors: Guillaume De Nanteuil, Philippe Gloanec, Tony Verbeuren, Alain Rupin, Marie-Odile Vallez
-
Publication number: 20010009915Abstract: Compound of formula (I): 1Type: ApplicationFiled: January 18, 2001Publication date: July 26, 2001Inventors: Gilbert Lavielle, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Jean-Jacques Descombes
-
Patent number: 6048875Abstract: A compound of formula (I): ##STR1## wherein: X represents oxygen, sulphur, or NR.sub.3 wherein R.sub.3 is as defined in the description,Y represents oxygen, sulphur, NR.sub.3, or may a single bond when X represents NR.sub.3,Z represents nitrogen, carbon, or CH,A represents a single bond, alkylene (optionally substituted), arylene, cycloalkylene, heterocycle, or --SO.sub.2 --R.sub.4 -- wherein R.sub.4 is as defined in the description,W represents hydroxy, alkoxy, aryloxy, arylalkoxy, cycloalkyloxy, heterocycle bonded to oxygen, amino, or hydroxyamino,Ra, Rb, Rc, Rd, which may be the same or different, each independently of the others are as defined in the description,R.sub.1 represents aryl substituted by one to five identical or different substituents, each independently of the others,R.sub.Type: GrantFiled: April 26, 1999Date of Patent: April 11, 2000Assignee: Adir et CompagnieInventors: Guillaume De Manteuil, Christine Lila, Tony Verbeuren, Alain Rupin
-
Patent number: 6046205Abstract: Compound of formula (I): ##STR1## wherein: n is 0 or 1,A represents a .sigma. bond or alkylene or alkenylene,X represents nitrogen or C--R.sub.2,R.sub.1 represents hydrogen or alkyl,G.sub.1 represents any one of the groups defined in the description.These compounds are useful for treating a living body afflicted with venous insufficiency, and/or migraine, and/or migraine associated with vascular diseases.Type: GrantFiled: April 26, 1999Date of Patent: April 4, 2000Assignee: Adir et CompagnieInventors: Gilbert Lavielle, Olivier Muller, Christine Vayssettes-Courchay, Jean-Jacques Descombes, Tony Verbeuren
-
Patent number: 6020336Abstract: Compound of formula (I): ##STR1## wherein: n is 0 or 1,A represents a .sigma. bond or alkylene or alkenylene,X represents nitrogen or C--R.sub.2,R.sub.1 represents hydrogen or alkyl, andG.sub.1 represents any one of the groups defined in the description and medicaments containing the same.Type: GrantFiled: September 2, 1998Date of Patent: February 1, 2000Inventors: Gilbert Lavielle, Olivier Muller, Christine Vayssettes-Courchay, Jean-Jacques Descombes, Tony Verbeuren
-
Patent number: 6013667Abstract: Compounds of formula (I): in which:R.sub.a and R.sub.b, identical or different, represent hydrogen or alkyl or together form a bond,R.sub.C represents hydroxyl optionally substituted alkoxy, or optionally substituted amino,R.sub.1 represents hydrogen or --O--NO.sub.2, --O--NO, or --S--NO,R.sub.2 and R.sub.3, identical or different, represent hydrogen, alkyl, or optionally substituted phenyl,X represents oxygen or --NH--CO--,m represents 0 or 1,n represents an integer such that 0.ltoreq.n.ltoreq.6,p represents 0 or 1,R.sub.4 represents hydrogen, optionally substituted alkyl, optionally substituted phenyl, or a group as defined in the description,R.sub.5 represents hydrogen or alkyl,R.sub.6 represents hydrogen or alkyl,or R.sub.5 and R.sub.6 together form a chain --(CH.sub.2).sub.t -- in which t represents 1 or 2,q represents 0, 1, or 2,r represents an integer such that 0.ltoreq.r.ltoreq.6,R.sub.d and R.sub.Type: GrantFiled: February 27, 1998Date of Patent: January 11, 2000Assignee: Adir Et CompagnieInventors: Gilbert Lavielle, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Jean-Jacques Descombes
-
Patent number: 5814622Abstract: Compound of formula (I) ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, represent hydrogen or alkyl or alternatively R.sub.1 and R.sub.2 form, with the carbon atom which bears them, cycloalkyl,R.sub.3 represents hydrogen or alkyl, phenyl or benzyl,R.sub.4 represents:optionally substituted amino, optionally substituted amindino, optionally substituted guanidino, optionally substituted isothioureido, optionally substituted iminomethylamino, mercapto substituted with heterocyclic, or heterocyclic,R.sub.5 and R.sub.6 each represent hydrogen or alkyl, or ##STR2## forms a boronic ester of pinanediol, m represents an integer such that 0.ltoreq.m.ltoreq.6,n represents an integer such that 1.ltoreq.n.ltoreq.6,A represents any one of the following groups:* optionally substituted bicycloalkyl (C.sub.5 -C.sub.10)phenyl,* or a group of formula: ##STR3## A.sub.1 represents --CO--, --CS--, --SO.sub.Type: GrantFiled: February 27, 1997Date of Patent: September 29, 1998Assignee: Adir et CompagnieInventors: Guillaume de Nanteuil, Philippe Gloanec, Christine Lila, Bernard Portevin, Tony Verbeuren, Alain Rupin, Serge Simonet
-
Patent number: 5792789Abstract: Acids and esters of diosmetin of formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are as defined in the description, and the physiologically tolerable salts thereof.The said compounds can be used as medicaments in the treatment of chronic venous insufficiency and any other disorder involving hyperpermeability and/or inflammation.Type: GrantFiled: April 25, 1997Date of Patent: August 11, 1998Assignee: Adir et CompagnieInventors: Michel Wierzbicki, Marie-Francoise Boussard, Tony Verbeuren, Marie-Odile Vallez
-
Patent number: 5786330Abstract: The invention relates to the compounds of formula (I) (SEQ ID NO: I:H-phe-A.sub.1 -Arg-Pro-(Gly).sub.4 -Asn-Gly-Asp-Phe-Glu-Abo-Ile-Pro-Glu-Glu-A.sub.2 -Leu-glu-OH(I)in which A.sub.1 and A.sub.2 are as defined in the description. Medicinal products containing the same are useful as anticoagulants.Type: GrantFiled: April 2, 1996Date of Patent: July 28, 1998Assignee: Adir et CompagnieInventors: Jean-Luc Fauchere, Christophe Thurieau, Tony Verbeuren, Alain Rupin, Serge Simonet
-
Patent number: 5648374Abstract: Compounds of formula (I): ##STR1## in which: X represents --CH.sub.2 --, --(CH.sub.2).sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 --, --S--CH.sub.2 --, --SO--CH.sub.2 -- or --SO.sub.2 --CH.sub.2 --,Y represents oxygen or sulfur or --NR.sub.5 --,R.sub.1 represents halogen, linear or branched (C.sub.1 -C.sub.6) alkyl (unsubstituted or substituted), hydroxyl or linear or branched (C.sub.1 -C.sub.6) alkoxy,R.sub.2 represents hydrogen or halogen, linear or branched (C.sub.1 -C.sub.6) alkyl (unsubstituted or substituted), hydroxyl, linear or branched (C.sub.1 -C.sub.6) alkoxy or linear or branched (C.sub.1 -C.sub.6) alkylthio,R.sub.3 represents hydrogen or halogen, linear or branched (C.sub.1 -C.sub.6) alkyl (unsubstituted or substituted), hydroxyl, linear or branched (C.sub.1 -C.sub.6) alkoxy or linear or branched (C.sub.1 -C.sub.6) alkylthio,R.sub.4 represents hydrogen or amino (unsubstituted or substituted)R.sub.5 represents hydrogen or linear or branched (C.sub.1 -C.sub.6) alkyl, or alternativelyR.sub.1 and R.sub.Type: GrantFiled: April 11, 1995Date of Patent: July 15, 1997Assignee: ADIR et CompagnieInventors: Alex Cordi, Jean-Michel Lacoste, Michel Laubie, Tony Verbeuren, Jean-Jacques Descombes, Mark Millan