Patents by Inventor Tony Yantao Zhang

Tony Yantao Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8124776
    Abstract: The present invention provides for novel compounds of formula I wherein X is S or S(O); R1 and R2 are each independently selected from the group consisting of —CH2CH3 and phenyl; or R1 and R2 combine to form morpholino; and processes to prepare arzoxifene.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: February 28, 2012
    Assignee: Eli Lilly and Company
    Inventors: Charles Arthur Alt, Douglas Patton Kjell, Tony Yantao Zhang, Fu-Yao Zhang, Jared Wade Fennell, Kevin Dale Seibert
  • Publication number: 20100137602
    Abstract: The present invention provides for novel compounds of formula I wherein X is S or S(O); R1 and R2 are each independently selected from the group consisting of —CH2CH3 and phenyl; or R1 and R2 combine to form morpholino; and processes to prepare arzoxifene.
    Type: Application
    Filed: March 3, 2008
    Publication date: June 3, 2010
    Inventors: Charles Arthur Alt, Douglas Patton Kjell, Tony Yantao Zhang, Fu-Yao Zhang, Jared Wade Fennell, Kevin Dale Siebert
  • Patent number: 7309702
    Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.
    Type: Grant
    Filed: September 13, 2005
    Date of Patent: December 18, 2007
    Assignees: Avera Pharmaceuticals, Inc., Eli Lilly and Company
    Inventors: Alexander Glenn Godfrey, Daniel Timothy Kohlman, John Cunningham O'Toole, Yao-Chang Xu, Tony Yantao Zhang, Jeffrey Forrester McKelvy
  • Patent number: 7045628
    Abstract: The present invention relates to a one-pot process for preparing a compound of formula I: I; by reacting a compound of formula II with a compound of formula III: in the presence of a suitable solvent, a suitable base, a palladium catalyst and a suitable ligand.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: May 16, 2006
    Assignee: Eli Lilly and Company
    Inventors: Scott Allan May, Thomas Michael Wilson, Tony Yantao Zhang
  • Patent number: 7001908
    Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: February 21, 2006
    Assignees: Avera Pharmaceuticals, Inc., Eli Lilly and Company
    Inventors: Alexander Glenn Godfrey, Daniel Timothy Kohlman, John Cunningham O'Toole, Yao-Chang Xu, Tony Yantao Zhang
  • Patent number: 6946579
    Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: September 20, 2005
    Assignee: Eli Lilly and Company
    Inventors: Alexander Glenn Godfrey, Daniel Timothy Kohlman, John Cunningham O'Toole, Yao-Chang Xu, Tony Yantao Zhang
  • Publication number: 20040133047
    Abstract: The present invention relates to a one-pot process for preparing a compound of formula I: I; by reacting a compound of formula II with a compound of formula III: in the presence of a suitable solvent, a suitable base, a palladium catalyst and a suitable ligand.
    Type: Application
    Filed: May 20, 2003
    Publication date: July 8, 2004
    Inventors: Scott Allan May, Thomas Michael Wilson, Tony Yantao Zhang
  • Publication number: 20040049083
    Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.
    Type: Application
    Filed: July 2, 2003
    Publication date: March 11, 2004
    Inventors: Alexander Glenn Godfrey, Daniel Timothy Kohlman, John Cunningham O'Toole, Yao-Chang Xu, Tony Yantao Zhang
  • Publication number: 20040044009
    Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.
    Type: Application
    Filed: April 16, 2003
    Publication date: March 4, 2004
    Inventors: Alexander Glenn Godfrey, Daniel Timothy Kohlman, John Cunningham O'Toole, Yao-Chang Xu, Tony Yantao Zhang
  • Publication number: 20030225282
    Abstract: This invention provides a process for the arylation of lactones to form to chiral and achiral aryllactones having high enantioselectivity where applicable.
    Type: Application
    Filed: March 18, 2003
    Publication date: December 4, 2003
    Inventors: Tony Yantao Zhang, Hongbin Zhang, Christophor Scott Proctor
  • Patent number: 6538136
    Abstract: The present invention provides a novel process for the preparation of substituted piperidine-4-ones useful as intermediates in the preparation of pharmaceuticals.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: March 25, 2003
    Assignee: Eli Lilly and Company
    Inventors: John Robert Rizzo, Michael Alexander Staszak, Tony Yantao Zhang
  • Publication number: 20020169170
    Abstract: A method for potentiating the action of a serotonin reuptake inhibitor in increasing the availability of serotonin, norepinephrin and dopamine in the brain, comprising administering to a patient in need of such treatment a serotonin reuptake inhibitor in combination with an effective amount of a compound of the formula 1
    Type: Application
    Filed: December 18, 2001
    Publication date: November 14, 2002
    Inventors: Alexander Glenn Godfrey, Daniel Timothy Kohlman, John Cunningham O' Toole, Yao-Chang Xu, Tony Yantao Zhang
  • Patent number: 6376230
    Abstract: This invention provides processes for preparing intermediates useful for the preparation of cryptophycin compounds.
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: April 23, 2002
    Assignee: Eli Lilly and Company
    Inventors: James Abraham Aikins, Barbara Shreve Briggs, Tony Yantao Zhang, Milton Joseph Zmijewski, Jr.
  • Patent number: 6372936
    Abstract: A process for resolving amino protected racemic 3-amino-2-methylpropionic acid which comprises the steps of: (1) reacting said amino protected acid with a protected amino group with an enantiomer of a chiral amine to form diastereomeric salts; (2) recrystallizing the diastereomeric salts from ethyl acetate to separate the diastereomeric salts into crystal fractions; and (3) releasing the resolved acid from the diastereomeric salt by treating the diastereomeric salt with a basic solution is disclosed. A process for the preparation of the cryptophycin molecules is also disclosed.
    Type: Grant
    Filed: May 8, 2000
    Date of Patent: April 16, 2002
    Assignee: Eli Lilly and Company
    Inventors: James Abraham Aikins, Tony Yantao Zhang
  • Publication number: 20010003749
    Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.
    Type: Application
    Filed: January 3, 2001
    Publication date: June 14, 2001
    Inventors: Alexander Glenn Godfrey, Daniel Timothy Kohlman, John Cunningham O'Toole, Yao-Chang Xu, Tony Yantao Zhang
  • Patent number: 6103913
    Abstract: This invention provides processes for preparing lactone intermediates useful for the preparation of pharmaceutical compounds such as tetrahydrolipstatin and cryptophycin compounds.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: August 15, 2000
    Assignees: Eli Lilly and Company, Wayne State University, University of Hawaii
    Inventors: David Allen Hay, Tony Yantao Zhang
  • Patent number: 6090949
    Abstract: The present invention relates to intermediates and processes for preparing benzothiophenes.
    Type: Grant
    Filed: April 29, 1998
    Date of Patent: July 18, 2000
    Assignee: Eli Lilly and Company
    Inventors: John McNeill McGill, III, Jerry Wayne Misner, Tony Yantao Zhang
  • Patent number: 6043360
    Abstract: The instant invention provides intermediates and processes for the preparation of compounds of formula IV ##STR1## wherein: n is 0, 1, or 2;R is hydrogen or C.sub.1 -C.sub.4 alkyl;X.sup.1 is hydrogen, cyano, 4-hydroxybenzoyl, 4-halobenzoyl, or 4-(C.sub.1 -C.sub.4 alkoxy)benzoyl;Y is NR.sup.4 R.sup.5, 4-hydroxyphenyl, or 4-(C.sub.1 -C.sub.4 alkoxy)phenyl;and R.sup.4 and R.sup.5 are independently hydrogen or C.sub.1 -C.sub.4 alkyl.
    Type: Grant
    Filed: April 29, 1998
    Date of Patent: March 28, 2000
    Assignee: Eli Lilly and Company
    Inventors: Tony Yantao Zhang, John Paul Gardner
  • Patent number: 5977383
    Abstract: The instant invention provides improved processes for preparing benzothiophenes utilizing cation exchange resins.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jeffrey Thomas Vicenzi, Tony Yantao Zhang