Patents by Inventor Tonya Caralla

Tonya Caralla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enrichment of tissue-derived adult stem cells based on retained extracellular matrix material
    Patent number: 9045735
    Abstract: Methods for enriching, detecting, or using adult stem cells through the use of recognition ligands that specifically bind to ECM components retained to the surfaces of adult stem cells are described. An ECM component such as hyaluronan that is retained to the surfaces of adult stem cells when removed from animal tissues can be used to detect a diverse population of adult stem cells based on the nature of the ECM niche region in which the adult stem cells normally reside. For example, a separation method such as magnetic separation can be used to detect and isolate or enrich adult stem cells based on a recognition ligand that is specific for an ECM component that is retained to the surfaces of adult stem cells to a greater degree than to other cells in the population.
    Type: Grant
    Filed: April 3, 2008
    Date of Patent: June 2, 2015
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: George Muschler, Tonya Caralla, Vincent Hascall, Ronald Midura
  • Enrichment of Tissue-Derived Adult Stem Cells Based on Retained Extracellular Matrix Material
    Publication number: 20100167316
    Abstract: Methods for enriching, detecting, or using adult stem cells through the use of recognition ligands that specifically bind to ECM components retained to the surfaces of adult stem cells are described. An ECM component such as hyaluronan that is retained to the surfaces of adult stem cells when removed from animal tissues can be used to detect a diverse population of adult stem cells based on the nature of the ECM niche region in which the adult stem cells normally reside. For example, a separation method such as magnetic separation can be used to detect and isolate or enrich adult stem cells based on a recognition ligand that is specific for an ECM component that is retained to the surfaces of adult stem cells to a greater degree than to other cells in the population.
    Type: Application
    Filed: April 3, 2008
    Publication date: July 1, 2010
    Applicant: THE CLEVELAND CLINIC FOUNDATION
    Inventors: George Muschler, Tonya Caralla, Vincent Hascall, Ronald Midura