Patents by Inventor Toomas MOKS

Toomas MOKS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS OF MANUFACTURE OF ANNEXIN V
    Publication number: 20240116982
    Abstract: The present invention provides a process for the recovery and/or purification of a recombinantly expressed intracellular protein comprising the sequence of Annexin A5 (AnxA5) from an endotoxin-producing host cell with a cell wall, wherein the process comprises releasing the intracellular protein from the host cell, characterised in that the step of releasing the intracellular AnxA5 protein is conducted in the presence of a homogenisation buffer comprising non-ionic detergent, and preferably wherein the process does not include any centrifugation steps for the recovery and/or purification of the AnxA5 protein after its release from the host cell and/or in which the AnxA5 protein remains in solution throughout the process except when temporarily bound to any chromatographic resins.
    Type: Application
    Filed: August 4, 2023
    Publication date: April 11, 2024
    Applicant: ANNEXIN PHARMACEUTICALS AB
    Inventors: Toomas MOKS, Jan Christoph REICH
  • Process of manufacture of annexin V
    Patent number: 11773134
    Abstract: The present invention provides a process for the recovery and/or purification of a recombinantly expressed intracellular protein comprising the sequence of Annexin A5 (AnxA5) from an endotoxin-producing host cell with a cell wall, wherein the process comprises releasing the intracellular protein from the host cell, characterised in that the step of releasing the intracellular AnxA5 protein is conducted in the presence of a homogenisation buffer comprising non-ionic detergent, and preferably wherein the process does not include any centrifugation steps for the recovery and/or purification of the AnxA5 protein after its release from the host cell and/or in which the AnxA5 protein remains in solution throughout the process except when temporarily bound to any chromatographic resins.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: October 3, 2023
    Assignee: ANNEXIN PHARMACEUTICALS AB
    Inventors: Toomas Moks, Jan Christoph Reich
  • Process of manufacture of annexin V
    Patent number: 11472837
    Abstract: The present invention provides a process for the recovery and/or purification of a recombinantly expressed intracellular protein comprising the sequence of Annexin A5 (AnxA5) from an endotoxin-producing host cell with a cell wall, wherein the process comprises releasing the intracellular protein from the host cell, characterised in that the step of releasing the intracellular AnxA5 protein is conducted in the presence of a homogenisation buffer comprising non-ionic detergent, and preferably wherein the process does not include any centrifugation steps for the recovery and/or purification of the AnxA5 protein after its release from the host cell and/or in which the AnxA5 protein remains in solution throughout the process except when temporarily bound to any chromatographic resins.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: October 18, 2022
    Assignee: ANNEXIN PHARMACEUTICALS AB
    Inventors: Toomas Moks, Jan Christoph Reich
  • PROCESS OF MANUFACTURE OF ANNEXIN V
    Publication number: 20210347819
    Abstract: The present invention provides a process for the recovery and/or purification of a recombinantly expressed intracellular protein comprising the sequence of Annexin A5 (AnxA5) from an endotoxin-producing host cell with a cell wall, wherein the process comprises releasing the intracellular protein from the host cell, characterised in that the step of releasing the intracellular AnxA5 protein is conducted in the presence of a homogenisation buffer comprising non-ionic detergent, and preferably wherein the process does not include any centrifugation steps for the recovery and/or purification of the AnxA5 protein after its release from the host cell and/or in which the AnxA5 protein remains in solution throughout the process except when temporarily bound to any chromatographic resins.
    Type: Application
    Filed: May 27, 2021
    Publication date: November 11, 2021
    Inventors: Toomas MOKS, Jan Christoph REICH