Abstract: Methods of data analysis, methods of detection, methods of treatment, compositions, and kits associated with treatment of diarrheal disorders are disclosed herein. Inventive concepts disclosed herein can assist stake holders in relieving patient suffering by identifying appropriate therapeutic regimens in an individualized and/or accurate manner.

Abstract: Embodiments of the disclosure include methods and compositions related to accurate diagnosis and treatment of medical conditions having diarrhea as a symptom. In specific cases, the disclosure concerns accurate assessment of a diarrheal cause related to the presence or risk that may or may not be a pathogenic infection, such as a Clostridioides difficule infection (CDI). Particular embodiments encompass one or more specific features that provide information for accurate diagnosis and treatment of CDI versus another cause for diarrhea.

Abstract: Embodiments include methods for generating a metabolite profile of a stool sample and methods of assessing the status of a subject using the metabolic profile derived from a stool sample.

Abstract: Embodiments of the invention include methods and/or compositions for analysis of samples for C. difficile infection to determine whether or not an individual is at risk for having recurrent C. difficile infection or a CDI misdiagnosis. Methods include characterization of microflora composition from the gut, wherein alterations of the microflora gut composition are indicative of recurrence of infection. Methods include analysis of nucleic acids from the gut, such as 16S rRNA as being identifying of a particular bacteria in the analysis of bacterial populations of the gut.

Abstract: Embodiments of the invention include methods and/or compositions for analysis of samples for C. difficile infection to determine whether or not an individual is at risk for having recurrent C. difficile infection or a CDI misdiagnosis. Methods include characterization of microflora composition from the gut, wherein alterations of the microflora gut composition are indicative of recurrence of infection. Methods include analysis of nucleic acids from the gut, such as 16S rRNA as being identifying of a particular bacteria in the analysis of bacterial populations of the gut.

Abstract: Embodiments include methods for generating a metabolite profile of a stool sample and methods of assessing the status of a subject using the metabolic profile derived from a stool sample.

Abstract: Provided herein are novel onco-fetal carbohydrate motifs present in adenocarcinoma cells. This novel carbohydrate motif is preferentially recognized by tomato fruit lectin-conotoxin. Also provided are methods for inhibiting proliferation and growth of cancer cells and for treating pathophysiological conditions, e.g., cancer, chronic pain, inflammation and/or a microbial infection, by contacting such cells with or administering tomato fruit lectin-conotoxin or similar natural or bioengineered molecules. In addition provided herein are genetically modified plants and seed, fruit, progeny, and hybrids therefrom and a genetically modified foodstuffs overexpressing a lectin-conotoxin. Further provided are DNA and expression vectors expressing lectin-conotoxin described herein.