Patents by Inventor Toralf Senger

Toralf Senger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180291389
    Abstract: Assay method, comprising providing a plant capable of expressing a delta-12 desaturase, wherein said delta-12 desaturase has at least 50% total amino acid sequence identity to at least one of the sequences SEQ ID NO. 328 to 336, and/or at least 59% total amino acid sequence similarity to at least one of the sequences SEQ ID NO. 328 to 336, and wherein the plant is also capable of expressing at least one or more enzymes of unsaturated fatty acid metabolism, of which enzymes at least one is capable of using linoleic acid as a substrate, and of which enzymes at least one is supposedly connected to a plant metabolic property, growing the plant, and measuring said plant metabolic property for said plant.
    Type: Application
    Filed: November 13, 2015
    Publication date: October 11, 2018
    Inventors: Toralf Senger, Heiko A. Haertel
  • Publication number: 20180291390
    Abstract: The present invention generally is concerned with the modification of plant lipids containing PUFAs. In this context, the invention is particularly concerned with plants and plant materials for such modifications, wherein the plants preferably are oilseed plants. Regarding plant parts, the invention is particularly concerned with seeds of such plants and preferably seeds of oilseed plants. The invention is also concerned with plant positions obtainable or obtained by the modification method of the invention, and with full stuff of feedstuff comprising such liquid compositions.
    Type: Application
    Filed: November 13, 2015
    Publication date: October 11, 2018
    Inventors: Toralf SENGER, Carl ANDRE
  • Publication number: 20180142217
    Abstract: The invention provides nucleic acid molecules which encodes a novel fatty acid desaturase, KCS, KCR and/or LACS from Thraustochytrium aureum and Sphaeroforma arctica. The invention also provides recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA and for screening for delta-4 desaturases.
    Type: Application
    Filed: January 8, 2018
    Publication date: May 24, 2018
    Applicant: BASF PLANT SCIENCE COMPANY GMBH
    Inventors: Laurent Marty, Toralf Senger
  • Patent number: 9879234
    Abstract: The invention provides nucleic acid molecules which encodes a novel fatty acid desaturase, KCS, KCR and/or LACS from Thraustochytrium aureum and Sphaeroforma arctica. The invention also provides recombinant expression vectors containing the nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA and for screening for delta-4 desaturases.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: January 30, 2018
    Assignee: BASF PLANT SCIENCE COMPANY GMBH
    Inventors: Laurent Marty, Toralf Senger
  • Patent number: 9828589
    Abstract: The present invention pertains to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucleotides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: November 28, 2017
    Assignee: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Sten Stymne, Jenny Lindberg Yilmaz
  • Publication number: 20160319249
    Abstract: The present invention relates to methods for the conversion of the substrate specificity of desaturases. Specifically, the present invention pertains to a method for the conversion of the substrate specificity of a ?5 and/or ?6 desaturase to the substrate specificity of a ?4 desaturase, the method comprising: identifying regions and/or amino acid residues which control the substrate specificity of (i) the ?5 and/or ?6 desaturase and (ii) the ?4 desaturase; and replacing in the amino acid sequence of the mentioned ?5 and/or ?6 desaturase, the regions and/or amino acid residues which control the substrate specificity of the ?5 and/or ?6 desaturase, by the corresponding regions and/or amino acid residues which control the substrate specificity of the ?4 desaturase, thereby converting the substrate specificity of the ?5 and/or ?6 desaturase to the substrate specificity of the ?4 desaturase.
    Type: Application
    Filed: December 17, 2014
    Publication date: November 3, 2016
    Inventors: Toralf Senger, Patricia Vrinten, Ze Long Lim
  • Patent number: 9458477
    Abstract: The invention provides isolated nucleic acid molecules which encode a fatty acid desaturase, KCS, KCR, DH and ECR from Nannochloropsis oculata. The invention also provides recombinant expression vectors containing desaturase, KCS, KCR, DH and ECR nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: October 4, 2016
    Assignee: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Jörg Bauer, Laurent Marty
  • Publication number: 20160272951
    Abstract: The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucleotides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
    Type: Application
    Filed: May 20, 2016
    Publication date: September 22, 2016
    Inventors: Toralf Senger, Laurent MARTY, Sten STYMNE, Jenny LINDBERG YILMAZ, Johnathan A. NAPIER, Olga SAYANOVA, Richard HASLAM, Ruiz Lopez NOEMI
  • Patent number: 9428757
    Abstract: The invention in principle pertains to the field of recombinant manufacture of fatty acids. It provides novel nucleic acid molecules comprising nucleic acid sequences encoding fatty acid desaturases, elongases, acyltransferases, terminator sequences and high expressing seed-specific promoters operatively linked to the said nucleic acid sequences wherein nucleic acid expression enhancing nucleic acids (NEENAs) are functionally linked to said promoters.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: August 30, 2016
    Assignee: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Jörg Bauer, Josef Martin Kuhn
  • Patent number: 9388437
    Abstract: The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucletides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: July 12, 2016
    Assignee: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Laurent Marty, Sten Stymne, Jenny Lindberg Yilmaz, Johnathan A. Napier, Olga Sayanova, Richard Haslam, Ruiz Lopez Noemi
  • Publication number: 20160168584
    Abstract: The present invention relates to transgenic nucleic acids, expression cassettes, vectors, plant cells, plant organs and plants. The invention also relates to methods for increasing expression or activity of a target gene, particularly in a plant cell or plant organ, and also to uses of recombinant nucleic acids and expression cassettes to increase expression or activity of a target gene or for manufacturing of a vector, plant cell, plant organ or plant. Incidentally, the invention relates to enhancers for achieving increased expression or activity of a target gene, particularly in a plant cell or plant organ, when operably linked to a promoter functional in such plant cell, plant organ or plant. The invention is described herein with reference to the technical field of production of polyunsaturated fatty acids (PUFAs), without being limited to this technical field. For the production of desired molecules in plant cells, e.g.
    Type: Application
    Filed: July 3, 2014
    Publication date: June 16, 2016
    Applicant: BASF PLANT SCIENCE COMPANY GMBH
    Inventors: Toralf Senger, Joerg Bauer
  • Publication number: 20160060606
    Abstract: The present invention pertains to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucleotides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
    Type: Application
    Filed: November 10, 2015
    Publication date: March 3, 2016
    Inventors: Toralf Senger, Sten Stymne, Jenny Lindberg Yilmaz
  • Patent number: 9212371
    Abstract: The present invention pertains to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucleotides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: December 15, 2015
    Assignee: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Sten Stymne, Jenny Lindberg Yilmaz
  • Patent number: 9139854
    Abstract: The present invention relates to polynucleotides from Cochliobolus heterostrophus C5, Cyanothece sp. CCY0110, Mycocentrospora acerin and Hyaloperonospora parasitica, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides according to the invention, and to the polypeptides encoded by the polynucleotides. The invention furthermore relates to antibodies against the polypeptides according to the invention. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: September 22, 2015
    Assignee: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Jörg Bauer, Johnathan A. Napier
  • Patent number: 9090902
    Abstract: The present invention relates to nucleic acids derived from Drechslera tritici-repentis, Cylindorcarpon herteronema, Diploida natalensis, Stagonospora nodorum, Microdochium nivalae and Periplaneta americana. The invention also relates to the individual coding sequences and to proteins encoded by these sequences in combination with other sequences as well as to a process for converting oleic acid to linoleic acid to Iinoleic acid and the production of arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid in a plant.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: July 28, 2015
    Assignees: BASF Plant Science GmbH, Bioriginal Food & Science Corp.
    Inventors: Jörg Bauer, Toralf Senger, Thorsten Zank, Xiao Qiu, Guohai Wu
  • Publication number: 20150203826
    Abstract: The invention provides nucleic acid molecules which encodes a novel fatty acid desaturase, KCS, KCR and/or LACS from Thraustochytrium aureum and Sphaeroforma arctica. The invention also provides recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA and for screening for delta-4 desaturases.
    Type: Application
    Filed: July 30, 2013
    Publication date: July 23, 2015
    Inventors: Laurent Marty, Toralf Senger
  • Publication number: 20140335579
    Abstract: The present invention relates to polynucleotides from Cochliobolus heterostrophus C5, Cyanothece sp. CCY0110, Mycocentrospora acerin and Hyaloperonospora parasitica, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides according to the invention, and to the polypeptides encoded by the polynucleotides. The invention furthermore relates to antibodies against the polypeptides according to the invention. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Inventors: Toralf Senger, Jörg Bauer, Johnathan A. Napier
  • Patent number: 8853383
    Abstract: The present invention is concerned with means and methods for allowing tissue specific and, in particular, seed specific expression of genes. The present invention, accordingly, relates to a polynucleotide comprising an expression control sequence which allows seed specific expression of a nucleic acid of interest being operatively linked thereto. Moreover, the present invention contemplates vectors, host cells, non-human transgenic organisms comprising the aforementioned polynucleotide as well as methods and uses of such a polynucleotide.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: October 7, 2014
    Assignee: BASF Plant Science GmbH
    Inventors: Jörg Bauer, Toralf Senger
  • Patent number: 8822662
    Abstract: The present invention relates to polynucleotides from Cochliobolus heterostrophus C5, Cyanothece sp. CCY0110, Mycocentrospora acerina and Hyaloperonospora parasitica, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides according to the invention, and to the polypeptides encoded by the polynucleotides. The invention furthermore relates to antibodies against the polypeptides according to the invention. Finally, the invention also relates to production processes for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: September 2, 2014
    Assignee: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Jörg Bauer, Johnathan A. Napier
  • Patent number: 8785163
    Abstract: The present invention relates to polynucleotides from Helobdella robusta, Laccaria bicolor, Lottia gigantea, Microcoleus chthonoplastes, Monosiga brevicollis, Mycosphaerella fijiensis, Mycospaerella graminicola, Naegleria gruberi, Nectria haematococca, Nematostella vectensis, Phycomyces blakesleeanus, Trichoderma resii, Physcomitrella patens, Postia placenta, Selaginella moellendorffii and Microdochium nivale, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotides according to the invention, and to the polypeptides encoded by the polynucleotides. The invention furthermore relates to antibodies against the polypeptides according to the invention.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: July 22, 2014
    Assignee: BASF Plant Science GmbH
    Inventors: Toralf Senger, Jörg Bauer