Patents by Inventor Torben Koch

Torben Koch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Low substituted polymyxins and compositions thereof
    Patent number: 10711040
    Abstract: The present invention relates to novel low substituted polymyxins and compositions thereof.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: July 14, 2020
    Assignee: XELLIA PHARMACEUTICALS APS
    Inventors: Vidar Bjornstad, Solvi Gunnes, Torben Koch, Claes Melander
  • Polymyxins, compositions, methods of making and methods of use
    Patent number: 10640536
    Abstract: Disclosed herein is a composition comprising at least one polymyxin or a salt thereof represented by formula (I) wherein R1 is an aliphatic linear or branched C6-C10 acyl group, or (I?) R5 is —CH(CH3)2, —CH2CH(CH3)2, —CH(CH3)CH2CH3, or —CH2C6H5; R6 is —CH(CH3)2, —CH2CH(CH3)2, or —CH(CH3)CH2CH3; each of R2, R3, R4, R7 and R8 is either —(CH2)xCH2NH2 or —(CH2)xCH2N(CH2SO3M)2; wherein x is 0 or 1; wherein M is a monovalent cation; and wherein at least three of R2, R3, R4, R7 and R8 are —(CH2)xCH2N(CH2SO3M)2.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: May 5, 2020
    Assignee: XELLIA PHARMACEUTICALS APS
    Inventors: Solvi Gunnes, Vidar Bjornstad, Torben Koch, Claes Melander, Martin Mansson
  • LOW SUBSTITUTED POLYMYXINS AND COMPOSITIONS THEREOF
    Publication number: 20170218024
    Abstract: The present invention relates to novel low substituted polymyxins and compositions thereof.
    Type: Application
    Filed: June 29, 2015
    Publication date: August 3, 2017
    Inventors: VIDAR BJORNSTAD, SOLVI GUNNES, TORBEN KOCH, CLAES MELANDER
  • POLYMYXINS, COMPOSITIONS, METHODS OF MAKING AND METHODS OF USE
    Publication number: 20160002296
    Abstract: Disclosed herein is a composition comprising at least one polymyxin or a salt thereof represented by formula (I) wherein R1 is an aliphatic linear or branched C6-C10 acyl group, or (I?) R5 is —CH(CH3)2, —CH2CH(CH3)2, —CH(CH3)CH2CH3, or —CH2C6H5; R6 is —CH(CH3)2, —CH2CH(CH3)2, or —CH(CH3)CH2CH3; each of R2, R3, R4, R7 and R8 is either —(CH2)XCH2NH2 or —(CH2)xCH2N(CH2SO3M)2; wherein x is 0 or 1; wherein M is a monovalent cation; and wherein at least three of R2, R3, R4, R7 and R are —(CH2)xCH2N(CH2SO3M)2.
    Type: Application
    Filed: January 9, 2014
    Publication date: January 7, 2016
    Inventors: SOLVI GUNNES, VIDAR BJORNSTAD, TORBEN KOCH, CLAES MELANDER, MARTIN MANSSON
  • Method for purification of colistin and purified colistin components
    Patent number: 9005990
    Abstract: The present invention concerns a method of purifying colistin using reverse phase chromatography, wherein loading a column with colistin base in acetic acid and high ethanol concentration and eluting with low ethanol concentration is performed.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: April 14, 2015
    Assignee: Xellia Pharmaceuticals APS
    Inventors: Torben Koch, Carsten Overblle Petersen
  • Method for purification of colistin and purified colistin components
    Publication number: 20120208981
    Abstract: The present invention concerns a method of purifying colistin using reverse phase chromatography, wherein loading a column with colistin base in acetic acid and high ethanol concentration and eluting with low ethanol concentration is performed.
    Type: Application
    Filed: September 29, 2010
    Publication date: August 16, 2012
    Applicant: XELLIA PHARMACEUTICALS APS
    Inventors: Torben Koch, Carsten Overblle Petersen
  • Glycopeptide composition with improved antibiotic activity
    Patent number: 7981859
    Abstract: A glycopeptide composition with improved antibiotic activity is disclosed, along with a method of preparing such a composition and a pharmaceutical composition made therefrom.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: July 19, 2011
    Assignee: Xellia Pharmaceuticals APS
    Inventors: Anita Mathiesen, Torben Koch, Tiemen Geert Pieter Reijns, Gerd Trine Suhr-Jessen, Jørn Thyme
  • Glycopeptide composition with improved antibiotic activity
    Patent number: 7919470
    Abstract: A glycopeptide composition with improved antibiotic activity is disclosed, along with a method of preparing such a composition and a pharmaceutical composition made therefrom.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: April 5, 2011
    Assignee: Xellia Pharmaceuticals APS
    Inventors: Anita Mathiesen, Torben Koch, Trine Suhr-Jessen, Joern Thyme, Tiemen Geert Pieter Reijns
  • Glycopeptide Composition with Improved Antibiotic Activity
    Publication number: 20070287663
    Abstract: A glycopeptide composition with improved antibiotic activity is disclosed, along with a method of preparing such a composition and a pharmaceutical composition made therefrom.
    Type: Application
    Filed: September 17, 2004
    Publication date: December 13, 2007
    Inventors: Anita Mathiesen, Torben Koch, Trine Suhr-Jessen, Joern Thyme, Tiemen Reijns
  • Glycopeptide composition with improved antibiotic activity
    Publication number: 20050080004
    Abstract: A glycopeptide composition with improved antibiotic activity is disclosed, along with a method of preparing such a composition and a pharmaceutical composition made therefrom.
    Type: Application
    Filed: September 17, 2004
    Publication date: April 14, 2005
    Inventors: Anita Mathiesen, Torben Koch, Tiemen Pieter Reijns, Gerd Suhr-Jessen, Jorn Thyme
  • Drug salts
    Patent number: 6077822
    Abstract: It has been found that sugar acid salts represent beneficial controlled release forms for basic organic drug compounds. Examples of appropriate salts include mono, di, oligo and polysaccharide poly-O-sulphonic acid salts of antibiotics such as tetracyclins and aminoglycosides.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: June 20, 2000
    Assignee: Dumex-Alpharma A/S
    Inventors: Hjarne Dyrsting, Torben Koch
  • Salts of amino glycosides
    Patent number: 5595977
    Abstract: The present invention relates to novel amino glycoside salts of sucrose-octa-O-sulfonic acid of formula I:([sucrose-octa-O-sulfonic acid.sup.8- ]-[R-(NH.sub.3.sup.+).sub.x ].sub.y -M.sub.z.sup.n+) (I)(x.multidot.y)+(z.multidot.n)=8x.multidot.y.epsilon.N.vertline.[4.ltoreq.x.multidot.y.ltoreq.8], wherein N is the set of natural numbers,x.epsilon.Z.vertline.[4.ltoreq.x.ltoreq.6], wherein Z is the set of integersz.epsilon.N.vertline.[0.ltoreq.z.ltoreq.4],n.epsilon.Z.vertline.[1.ltoreq.n.ltoreq.3],wherein R is a sugar moiety of an amino glycoside and M is a metal ion or an ammonium ion, said compounds being useful for treating ulcerations of the stomach and duodenum.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: January 21, 1997
    Assignee: Dumex-Alpharma A/S
    Inventors: Hjarne Dyrsting, Torben Koch
  • Salts of tetracyclines
    Patent number: 5538954
    Abstract: A salt of sucrose-octa-O-sulfonic acid and a tetracycline useful in inhibiting protein synthesis of bacteria.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: July 23, 1996
    Assignee: A/S Dumex (Dumex Ltd.)
    Inventors: Torben Koch, Hjarne Dyrsting