Abstract: The invention relates to a rotary actuator (1) to be installed between a dipper arm (9) and an excavator tool (12) of an excavator (2). The rotary actuator (1) comprises a first actuator part (20) adapted to be fixed to the dipper arm (9) or to the excavator tool (12), wherein the first actuator part (20) is formed with an inner cylindrical orifice (23) comprising first part guide means (24). The rotary actuator (1) further comprises a second actuator part (21) adapted to be fixed to the other of the dipper arm (9) or the excavator tool (12), wherein at least a part of the second actuator part (21) is arranged inside the inner cylindrical orifice (23) and wherein the second actuator part (21) is rotatably supported by the first actuator part (20) while being substantially axially fixed in relation to the first actuator part (20). Furthermore, an outer cylindrical surface (25) of the second actuator part (21) comprises second part guide means (26).

Abstract: The present invention relates to association of one or more polymorphisms located in the human SFRS8, CD83, SLAMF1, CD86, HRH1, IL2, TLR7, TLR8 and TLR10 genes to the occurrence of allergic diseases such as rhinitis, asthma, and atopic dermatitis, auto-immune diseases, infectious diseases, and graft/host incompatibilities. The invention relates both to methods for diagnosing a predisposition to said diseases, classifying said diseases and to methods and compositions for treating subjects with said diseases. Furthermore the invention relates to screens for identifying compounds effective in treating said diseases. The invention describes specific single nucleotide polymorphisms the presence of which in the genome of an individual is strongly associated with the predisposition of said individual to an immune related disease.

Abstract: There is provided a gene expression pattern which is clinically relevant to metastasizing breast cancer. In particular, the identity of genes that are correlated with patient survival and breast cancer recurrence are provided. The gene expression profile, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to predict survival of subjects afflicted with breast cancer and the likelihood of breast cancer recurrence. The invention thus provides for the use of a gene expression pattern (or profile or “signature”) which correlates with (and thus able to discriminate between) patients with good or poor survival outcomes.