Abstract: A method for forming a monolithic swirl nozzle configured to aerosolize a pharmaceutical drug. The swirl nozzle comprises an inlet for receiving the pharmaceutical drug to be aerosolized; a swirl chamber connected to the inlet and configured to aerosolize the pharmaceutical drug provided by the inlet; and an outlet connected to the swirl chamber and configured to discharge the aerosolized pharmaceutical drug. The method comprises providing a photoactivatable material and forming the swirl nozzle by selectively activating voxels in the photoactivatable material.

Abstract: A spray nozzle chip comprising: a first layer provided with a first layer orifice, and a mechanically flexible nozzle layer provided with a nozzle orifice, wherein the first layer has a valve seat arranged aligned with the nozzle orifice, wherein the spray nozzle chip has a valve functionality obtained by movement of the nozzle layer relative to the valve seat due to pressure changes, and wherein the nozzle layer is arranged at a distance from the valve seat when the nozzle layer is in a default non-pressurised state, whereby a gap with a gap length (L) is formed between the nozzle layer and the valve seat, wherein the gap length (L) is smaller than a dimension of a specific bacterial type, to thereby seal against bacterial ingrowth through the nozzle orifice of the specific bacterial type.

Abstract: A spray nozzle chip is presented having: a first layer provided with a first layer orifice, a mechanically flexible nozzle layer provided with a nozzle orifice, the spray nozzle chip having a valve functionality obtained by movement of the nozzle layer relative to the first layer due to pressure changes, wherein the nozzle orifice is closed when the nozzle layer is in a default non-pressurised state and wherein the nozzle orifice is opened and set in fluid communication with the first layer orifice when the nozzle layer is deformed due to pressure during a spraying operation, and wherein the spray nozzle chip further has a sealing layer configured to rupture when the nozzle layer is deformed due to applied pressure during a spraying operation.

Abstract: A spray nozzle chip is presented having: a first layer provided with a first layer orifice, a mechanically flexible nozzle layer provided with a nozzle orifice, the spray nozzle chip having a valve functionality obtained by movement of the nozzle layer relative to the first layer due to pressure changes, wherein the nozzle orifice is closed when the nozzle layer is in a default non-pressurised state and wherein the nozzle orifice is opened and set in fluid communication with the first layer orifice when the nozzle layer is deformed due to pressure during a spraying operation, and wherein the spray nozzle chip further has a sealing layer configured to rupture when the nozzle layer is deformed due to applied pressure during a spraying operation.