Abstract: The invention provides, in a method of perfusion magnetic resonance imaging of a region of interest in a vascularized animal subject, said method comprising administering a contrast agent bolus into the vascular system of said subject; determining the magnetic resonance signal strength si(t) for voxels (i) of said region of interest at a series of time values (t) over a period from before contrast agent arrival in said region of interest to at least the end of the first pass of said contrast agent through said region of interest; from the determined values si(t) for said signal strength and an arterial input function v(t), determining values for the tissue residue function ri(t) for each said voxel; and optionally generating an image of said region of interest from the determined values of ri(t); the improvement comprising generating from si(t) a voxel specific arterial function vi(t) and using said voxel specific arterial function to determine the values of the tissue residue function ri(t).

Abstract: A method of generating an enhanced perfusion image comprising the use of a blind deconvolution algorithm and the adiabatic approximation to the Johnson and Wilson model (aaJW) and generation of an image, wherein the blind deconvolution algorithm and the aaJW model are used in the generation of values of the following parameters: voxel specific arterial input function cp[t] and voxel specific tissue residue function r[t].

Abstract: The invention relates to a method of perfusion imaging, as well as to methods of post-imaging data manipulation and programs therefor.

Abstract: The invention provides, in a method of perfusion magnetic resonance imaging of a region of interest in a vascularized animal subject, said method comprising administering a contrast agent bolus into the vascular system of said subject; determining the magnetic resonance signal strength si(t) for voxels (i) of said region of interest at a series of time values (t) over a period from before contrast agent arrival in said region of interest to at least the end of the first pass of said contrast agent through said region of interest; from the determined values si(t) for said signal strength and an arterial input function v(t), determining values for the tissue residue function ri(t) for each said voxel; and optionally generating an image of said region of interest from the determined values of ri(t); the improvement comprising generating from si(t) a voxel specific arterial function vi(t) and using said voxel specific arterial function to determine the values of the tissue residue function ri(t).