Patents by Inventor Torild Wickstrom
Torild Wickstrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230068052Abstract: The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.Type: ApplicationFiled: October 10, 2022Publication date: March 2, 2023Inventors: Torild Wickstrom, Anders Svadberg, Ole Kristian Hjelstuen, Dag M. Evje, Liane Ochsenfeld
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Patent number: 11534494Abstract: The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.Type: GrantFiled: August 19, 2020Date of Patent: December 27, 2022Assignee: GE HEALTHCARE LIMITEDInventors: Knut Richard Dyrstad, Torild Wickstrom, Thanushan Rajanayagam, Kristine Romoren, Olav Ryan
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Patent number: 11504430Abstract: The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.Type: GrantFiled: December 21, 2011Date of Patent: November 22, 2022Assignee: GE HEALTHCARE LIMITEDInventors: Torild Wickstrom, Anders Svadberg, Ole Kristian Hjelstuen, Dag M Evje, Liane Ochsenfeld
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Publication number: 20220111052Abstract: The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.Type: ApplicationFiled: December 21, 2021Publication date: April 14, 2022Inventors: Knut Richard Dyrstad, Torild Wickstrom, Thanushan Rajanayagam, Kristine Romoren, Olav Ryan
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Publication number: 20220001034Abstract: The present invention provides a composition comprising anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid (18F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.Type: ApplicationFiled: July 2, 2021Publication date: January 6, 2022Inventors: Knut Richard Dyrstad, Torild Wickstrom, Thanushan Rajanayagam
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Patent number: 11077216Abstract: The present invention provides a composition comprising anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid (18F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.Type: GrantFiled: June 30, 2015Date of Patent: August 3, 2021Assignee: GE HEALTHCARE LIMITEDInventors: Knut Richard Dyrstad, Torild Wickstrom, Thanushan Rajanayagam
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Publication number: 20210030878Abstract: The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.Type: ApplicationFiled: August 19, 2020Publication date: February 4, 2021Inventors: Knut Richard Dyrstad, Torild Wickstrom, Thanushan Rajanayagam, Kristine Romoren, Olav Ryan
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Publication number: 20180177900Abstract: The present invention relates to a novel composition comprising 1-amino-3-[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.Type: ApplicationFiled: February 20, 2018Publication date: June 28, 2018Applicant: GE HEALTHCARE LIMITEDInventor: Torild Wickstrom
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Patent number: 10000518Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-ß-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.Type: GrantFiled: November 18, 2005Date of Patent: June 19, 2018Assignees: GE HEALTHCARE LIMITED, GE HEALTHCARE ASInventors: Lill Torild Wickstrom, Dirk-Jan in't Veld, Nigel John Osborn, Julian Grigg, Anthony Wilson
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Patent number: 9999692Abstract: The present invention relates to a novel composition comprising 1-amino-3-[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.Type: GrantFiled: March 28, 2014Date of Patent: June 19, 2018Assignee: GE Healthcare LimitedInventor: Torild Wickstrom
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Patent number: 9969761Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-?-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.Type: GrantFiled: April 22, 2014Date of Patent: May 15, 2018Assignees: GE HEALTHCARE AS, GE HEALTHCARE LIMITEDInventors: Torild Wickstrom, Dirk-Jan In't Veld, Nigel John Osborn, Julian Grigg, Anthony Wilson
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Publication number: 20170128597Abstract: The present invention provides a composition comprising anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid (18F-FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.Type: ApplicationFiled: June 30, 2015Publication date: May 11, 2017Inventors: Knut Richard Dyrstad, Torild Wickstrom, Thanushan Rajanayagam
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Publication number: 20160051710Abstract: The present invention relates to a novel composition comprising 1-amino-3[18F]-fluorocyclobutanecarboxylic acid ([18F]-FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [18F]-FACBC. Also provided by the invention is a method to obtain said composition.Type: ApplicationFiled: March 28, 2014Publication date: February 25, 2016Applicant: GE Healthcare LimitedInventor: Torild Wickstrom
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Patent number: 9061996Abstract: The present invention provides a method to prepare an 18F-labelled tricyclic indole compound comprising a solid-phase extraction (SPE) purification step. This method is particularly suitable for carrying out the radiofluorination method on an automated synthesizer. In addition to the radiofluorination method, the present invention provides a cassette designed to carry out the method on an automated synthesizer.Type: GrantFiled: December 14, 2011Date of Patent: June 23, 2015Assignee: GE Healthcare LimitedInventors: Dimitrios Mantzilas, Gry Helene Olaussen, Torild Wickstrom, Eric Horn, Imtiaz Khan
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Publication number: 20150018541Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-?-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.Type: ApplicationFiled: April 22, 2014Publication date: January 15, 2015Applicants: GE HEALTHCARE AS, GE HEALTHCARE LIMITEDInventors: Torild WICKSTROM, DIRK-JAN IN'T VELD, NIGEL JOHN OSBORN, JULIAN GRIGG, ANTHONY WILSON
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Publication number: 20130324715Abstract: The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.Type: ApplicationFiled: December 21, 2011Publication date: December 5, 2013Applicant: GE HEALTHCARE LIMITEDInventors: Torild Wickstrom, Anders Svadberg, Ole Kristian Hjelstuen, Dag M. Evje, Liane Ochsenfeld
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Publication number: 20130261315Abstract: The present invention provides a method to prepare an 18F-labelled tricyclic indole compound comprising a solid-phase extraction (SPE) purification step. This method is particularly suitable for carrying out the radiofluorination method on an automated synthesiser. In addition to the radiofluorination method, the present invention provides a cassette designed to carry out the method on an automated synthesiser.Type: ApplicationFiled: December 14, 2011Publication date: October 3, 2013Applicant: GE HEALTHCARE LIMITEDInventors: Dimitrios Mantzilas, Gry Helene Olaussen, Torild Wickstrom, Eric Horn, Imtiaz Khan
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Publication number: 20130217908Abstract: The invention relates to a method for improving stability of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). The invention further includes compositions comprising a radiopharmaceutical precursor and a drying agent, and cassettes for automated synthesis apparatus comprising the same.Type: ApplicationFiled: October 28, 2011Publication date: August 22, 2013Applicant: GE HEALTHCARE LIMITEDInventors: Tone Hauk Fritzell, Torild Wickstrom
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Patent number: 8496910Abstract: The invention relates to a method for improving stability of radiopharmaceutical precursors, and in particular non radiolabelled nucleoside derivatives which are used as precursors for production of radiolabelled nucleoside derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The invention further includes formulations of radiopharmaceutical precursors, and cassettes for automated synthesis apparatus comprising the same.Type: GrantFiled: June 20, 2007Date of Patent: July 30, 2013Assignee: GE Healthcare ASInventors: Svein Kvaale, Dirk-Jan In t Veld, Torild Wickstrom
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Publication number: 20100029930Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-?-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.Type: ApplicationFiled: November 18, 2005Publication date: February 4, 2010Inventors: Lill Torild Wickstrom, Dirk-Jan in't Veld, Nigel John Osborn, Julian Grigg, Anthony Wilson