Abstract: The present invention relates generally to amide containing heterobicyclic compounds having the following formulas: wherein R1, R2, D, and Q are as defined in the specification. More particularly, the present invention provides a new class of amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract: The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.

Abstract: The invention relates to an arrangement and to a method for the electromechanical drive for mold closing systems and calibration blow mandrel systems in blow molding machines, wherein the arrangement for the drive of an extrusion blow molding machine includes a push mechanism (3; 11), a push rod (4; 12) and exactly one electric motor (1; 9), wherein the push rod (4; 12) is movable by the push mechanism (3; 11) which is driven by the electric motor (1; 9), wherein the electric motor (1; 9) has an additional braking device (2; 10) which can be activated on the reaching of a required torque or a required force of the electric motor (2; 10) to hold the push rod (4; 12) in a state of maximum tension in its instantaneous position.

Abstract: The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.

Abstract: The invention relates to an arrangement and to a method for the electromechanical drive for mold closing systems and calibration blow mandrel systems in blow molding machines, wherein the arrangement for the drive of an extrusion blow molding machine includes a push mechanism (3; 11), a push rod (4; 12) and exactly one electric motor (1; 9), wherein the push rod (4; 12) is movable by the push mechanism (3; 11) which is driven by the electric motor (1; 9), wherein the electric motor (1; 9) has an additional braking device (2; 10) which can be activated on the reaching of a required torque or a required force of the electric motor (2; 10) to hold the push rod (4; 12) in a state of maximum tension in its instantaneous position.

Abstract: The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds having the following formulas: wherein R1, R2, R3, and R4 are as defined in the specification. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds amide containing heterobicyclic compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract: The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.

Abstract: A grinding machine for centerless grinding of workpieces is provided. The workpieces are disposed on a support in the area of a longitudinal plane of the grinding machine. A first slide is provided for a grinding wheel and positioned laterally relative to the longitudinal plane. A second slide is provided for a regulating wheel and is likewise positioned laterally with respect to the longitudinal plane. A first dressing tool is provided for dressing the grinding wheel at a first predetermined position and a second dressing tool for dressing the regulating wheel at a second predetermined position. The first and second predetermined positions are located in the area of the longitudinal plane.