Patents by Inventor Torsten Dunkern

Torsten Dunkern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-membered cyclic amines or lactames substituted with urea and phenyl
    Patent number: 10265310
    Abstract: The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: April 23, 2019
    Assignee: GrÜNENTHAL GMBH
    Inventors: Florian Jakob, Sonja Nordhoff, David Rider, Markus Wagener, Gregor Bahrenberg, Torsten Dunkern
  • 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL
    Publication number: 20180078541
    Abstract: The present invention relates to a compound according to general formula (I) which acts as a modulator of FPR2 and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by FPR2.
    Type: Application
    Filed: September 20, 2017
    Publication date: March 22, 2018
    Applicant: GRÜNENTHAL GMBH
    Inventors: FLORIAN JAKOB, SONJA NORDHOFF, DAVID RIDER, MARKUS WAGENER, GREGOR BAHRENBERG, TORSTEN DUNKERN
  • Methylpyrrolopyrimidinecarboxamides
    Patent number: 9376442
    Abstract: The compounds of Formula (I), wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase and are useful for treating or preventing idiopathic pulmonary lung fibrosis.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: June 28, 2016
    Assignee: Takeda GmbH
    Inventors: Josef Stadlwieser, Beate Schmidt, Heiko Bernsmann, Torsten Dunkern, Ewald Benediktus, Andreas Pahl, Ragna Hussong, Olaf Nimz, Matthias Mueller, Martin Viertelhaus
  • Novel Phthalazinone-Pyrrolopyrimidinecarboxamide Derivatives
    Publication number: 20160108049
    Abstract: The compounds of formula (1), in which R1, R7, R8, R9, R10, R17, R18, R19, R20 and m have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
    Type: Application
    Filed: December 3, 2015
    Publication date: April 21, 2016
    Inventors: Thomas STENGEL, Thomas MAIER, Alexander MANN, Josef STADLWIESER, Dieter FLOCKERZI, Andreas PAHL, Ewald BENEDIKTUS, Manuela HESSMANN, Tobias KANACHER, Ragna HUSSONG, Christof ZITT, Hans Christof HOLST, Rolf-Peter HUMMEL, Martin VIERTELHAUS, Hermann TENOR, Torsten DUNKERN, Armin HATZELMANN, Christian HESSLINGER
  • EP2 receptor agonists
    Patent number: 9309187
    Abstract: The compounds of formula (1) in which R1, R4, A and X have the meanings as given in the description, are novel effective EP2 agonists.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: April 12, 2016
    Assignee: Takeda GmbH
    Inventors: Angelika Hoffmeyer, Rainer Boer, Manuela Hessmann, Andreas Pahl, Torsten Dunkern, Simone Hartung, Christof Zitt, Jurgen Volz, Christiane Praechter, Mahindra Makhija, Hiteshkumar Jain, Sandip Gavade, Arati Prabhu, Manojkumar Tiwari, Ashish Keche, Sarvesh Patel
  • 3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives
    Patent number: 9018175
    Abstract: The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: April 28, 2015
    Assignee: Takeda GmbH
    Inventors: Dieter Flockerzi, Thomas Stengel, Alexander Mann, Harald Ohmer, Ulrich Kautz, Steffen Weinbrenner, Stefan Fischer, Christof Zitt, Armin Hatzelmann, Torsten Dunkern, Christian Hesslinger, Thomas Maier, Hermann Tenor, Clemens Braun, Raimund Külzer, Degenhard Marx
  • Novel EP2 Receptor Agonists
    Publication number: 20150080400
    Abstract: The compounds of formula (1) in which R1, R4, A and X have the meanings as given in the description, are novel effective EP2 agonists.
    Type: Application
    Filed: April 30, 2013
    Publication date: March 19, 2015
    Applicant: TAKEDA GMBH
    Inventors: Angelika Hoffmeyer, Rainer Boer, Manuela Hessmann, Andreas Pahl, Torsten Dunkern, Simone Hartung, Christof Zitt, Jurgen Volz, Christiane Praechter, Mahindra Makhija, Hiteshkumar Jain, Sandip Gavade, Arati Prabhu, Manojkumar Tiwari, Ashish Keche, Sarvesh Patel
  • METHYLPYRROLOPYRIMIDINECARBOXAMIDES
    Publication number: 20150073001
    Abstract: The compounds of Formula (I), wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase and are useful for treating or preventing idiopathic pulmonary lung fibrosis.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 12, 2015
    Inventors: Josef STADLWIESER, Beate SCHMIDT, Heiko BERNSMANN, Torsten DUNKERN, Ewald BENEDIKTUS, Andreas PAHL, Ragna HUSSONG, Olaf NIMZ, Matthias MUELLER, Martin VIERTELHAUS
  • Methylpyrrolopyrimidinecarboxamides
    Patent number: 8927557
    Abstract: The compounds of Formula (I), wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: January 6, 2015
    Assignee: Takeda GmbH
    Inventors: Josef Stadlwieser, Beate Schmidt, Heiko Bernsmann, Torsten Dunkern, Ewald Benediktus, Andreas Pahl, Ragna Hussong, Olaf Nimz, Matthias Mueller, Martin Viertelhaus
  • Methylpyrrolopyridinecarboxamides
    Patent number: 8816085
    Abstract: The compounds of Formula (I), wherein R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: August 26, 2014
    Assignee: Takeda GmbH
    Inventors: Josef Stadlwieser, Beate Schmidt, Heiko Bernsmann, Alexander Sudau, Torsten Dunkern, Ragna Hussong, Ewald Benediktus, Andreas Pahl
  • NOVEL PHTHALAZINONE-PYRROLOPYRIMIDINECARBOXAMIDE DERIVATIVES
    Publication number: 20140112945
    Abstract: The compounds of formula (1) in which R1, R7, R8, R9, R10, R17, R18, R19, R20 and m have the meanings as given in the description, are novel effective inhibitors of type 4 and type 5 phosphodiesterase.
    Type: Application
    Filed: June 12, 2012
    Publication date: April 24, 2014
    Applicant: TAKEDA GmbH
    Inventors: Thomas Stengel, Thomas Maier, Alexander Mann, Josef Stadlwieser, Dieter Flockerzi, Andreas Pahl, Ewald Benediktus, Manuela Hessmann, Tobias Kanacher, Ragna Hussong, Christof Zitt, Hans Christof Holst, Rolf-Peter Hummel, Martin Viertelhaus, Hermann Tenor, Torsten Dunkern, Armin Hatzelmann, Christian Hesslinger
  • NOVEL 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO[4,3-C] ISOQUINOLINE COMPOUNDS
    Publication number: 20140113877
    Abstract: The compounds of formula (1) in which A, X, R1, R2, R3 and R7 have the meanings as given in the description, are novel effective inhibitors of type 4 and type 5 phosphodiesterase.
    Type: Application
    Filed: June 12, 2012
    Publication date: April 24, 2014
    Applicant: Takeda GmbH
    Inventors: Dieter Flockerzi, Alexander Mann, Thomas Stengel, Harald Ohmer, Ulrich Kautz, Steffen Weinbrenner, Stefan Fischer, Hermann Tenor, Christof Zitt, Armin Hatzelmann, Torsten Dunkern, Christian Hesslinger, Clemens Braun, Ewald Benediktus, Andreas Pahl, Raimund Kuelzer, Degenhard Marx
  • Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines
    Patent number: 8445501
    Abstract: The compounds of Formula (I), in which R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the N-oxides of the compounds and the salts thereof and the stereoisomers of the compounds, the salts, the N-oxides of the compounds and the N-oxides of the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: May 21, 2013
    Assignee: Takeda GmbH
    Inventors: Josef Stadlwieser, Beate Schmidt, Heiko Bernsmann, Alexander Sudau, Torsten Dunkern, Degenhard Marx, Jörg Diefenbach
  • 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4,3-c] ISOQUINOLINE DERIVATIVES
    Publication number: 20120289474
    Abstract: The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
    Type: Application
    Filed: December 15, 2010
    Publication date: November 15, 2012
    Applicant: NYCOMED GMBH
    Inventors: Dieter Flockerzi, Thomas Stengel, Alexander Mann, Harald Ohmer, Ulrich Kautz, Steffen Weinbrenner, Stefan Fischer, Christof Zitt, Armin Hatzelmann, Torsten Dunkern, Christian Hesslinger, Thomas Maier, Hermann Tenor, Clemens Braun, Raimund Külzer, Degenhard Marx
  • Use for PDE5 inhibitors
    Patent number: 8278300
    Abstract: The present invention is concerned with the use of PDE5 inhibitors in medicine.
    Type: Grant
    Filed: January 4, 2010
    Date of Patent: October 2, 2012
    Assignee: Nycomed GmbH
    Inventors: Torsten Dunkern, Christian Schudt, Friedrich Grimminger, Hossein Ardeschir Ghofrani, Manfred Kaps, Bernhard Rosengarten
  • COMPOSITION COMPRISING A PDE4 INHIBITOR AND A PDE5 INHIBITOR
    Publication number: 20120196867
    Abstract: The claimed subject matter relates to pharmaceutical compositions comprising a PDE4 inhibitor and a PDE5 inhibitor and the treatment of a disease in which phosphodiesterase 4 (PDE4) and/or phosphodiesterase 5 (PDE5) is detrimental.
    Type: Application
    Filed: April 12, 2012
    Publication date: August 2, 2012
    Applicant: NYCOMED GMBH
    Inventors: Torsten DUNKERN, Armin HATZELMANN, Christian SCHUDT, Friedrich GRIMMINGER, Hossein Ardeschir GHOFRANI
  • METHYLPYRROLOPYRIMIDINECARBOXAMIDES
    Publication number: 20120149721
    Abstract: The compounds of Formula (I), wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
    Type: Application
    Filed: August 24, 2010
    Publication date: June 14, 2012
    Applicant: NYCOMED GMBH
    Inventors: Josef Stadlwieser, Beate Schmidt, Heiko Bernsmann, Torsten Dunkern, Ewald Benediktus, Andreas Pahl, Ragna Hussong, Olaf Nimz, Matthias Mueller, Martin Viertelhaus
  • METHYLPYRROLOPYRIDINECARBOXAMIDES
    Publication number: 20120142633
    Abstract: The compounds of Formula (I), wherein R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
    Type: Application
    Filed: August 24, 2010
    Publication date: June 7, 2012
    Applicant: NYCOMED GMBH
    Inventors: Josef Stadlwieser, Beate Schmidt, Heiko Bernsmann, Alexander Sudau, Torsten Dunkern, Ragna Hussong, Ewald Benediktus, Andreas Pahl
  • PYRROLOPYRIMIDINECARBOXAMIDES
    Publication number: 20110021479
    Abstract: The compounds of Formula (I), in which R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the N-oxides of the compounds and the salts thereof and the stereoisomers of the compounds, the salts, the N-oxides of the compounds and the N-oxides of the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
    Type: Application
    Filed: February 25, 2009
    Publication date: January 27, 2011
    Applicant: NYCOMED GMBH
    Inventors: Josef Stadlwieser, Beate Schmidt, Heiko Bernsmann, Alexander Sudau, Torsten Dunkern, Degenhard Marx, Jörg Diefenbach
  • COMPOSITION COMPRISING A PDE4 INHIBITOR AND A PDE5 INHIBITOR
    Publication number: 20100234382
    Abstract: The invention relates to the combined administration of a PDE4 inhibitor and a PDE5 inhibitor for the treatment of a disease in which phosphodiesterase 4 (PDE4) and/or phosphodiesterase 5 (PDE5) is detrimental.
    Type: Application
    Filed: May 24, 2010
    Publication date: September 16, 2010
    Applicant: NYCOMED GMBH
    Inventors: Torsten DUNKERN, Armin HATZELMANN, Christian SCHUDT, Friedrich GRIMMINGER, Hossein Ardeschir GHOFRANI