Patents by Inventor Torsten GEISSLER
Torsten GEISSLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250040580Abstract: The present invention relates to ingredients for improving the flavour of food products. It concerns flavouring compositions with 8Z, 11Z-heptadecadional, 8Z-heptadecenal and 7Z-hexadecenal and optionally further aldehydes. Furthermore, the present invention relates to preparations with improved taste characteristics comprising an inventive flavouring composition as well as the use of an inventive flavouring composition and a method for improving at least one taste characteristic in a preparation.Type: ApplicationFiled: December 7, 2021Publication date: February 6, 2025Applicant: SYMRISE AGInventors: Uwe BORNSCHEUER, In Jung KIM, Holger ZORN, Torsten GEIßLER, Jakob Peter LEY, Christoph HARMS, Susanne OTTE-HÖLSCHER, Sina BRUNS, Marco Alexander FRAATZ, Andreas Klaus HAMMER, Philipp HONOLD
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Publication number: 20240298686Abstract: The present invention relates to the use of naringenin for improving the taste quality of phloretin. Additionally, the present invention relates to a method for improving the taste quality of phloretin. Furthermore, the invention relates to aroma compositions containing naringenin and phloretin as well as semi-finished and finished products containing the aroma compositions.Type: ApplicationFiled: December 21, 2020Publication date: September 12, 2024Inventors: Torsten GEISSLER, Jakob Peter LEY, Egon GROSS, Katharina REICHELT, Thomas RIESS, Tom SOMERS
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Publication number: 20240225063Abstract: The present invention primarily relates to a process for production of one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulphuric compounds, the process comprising providing a culture medium comprising one or more components supporting growth of a fungus from the phylum Basidiomycota and being convertable to one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulfur aroma compounds; cultivating a fungus from the phylum Basidiomycota in or on the culture medium under conditions that support the growth of the fungus and formation of the one or more flavourings, and optionally recovering the one or more flavourings.Type: ApplicationFiled: February 22, 2021Publication date: July 11, 2024Inventors: Tobias TRAPP, Torsten GEISSLER, Jakob Peter LEY, Jens KOCH, Gerhard KRAMMER, Suzan YALMAN, Marco FRAATZ, Holger ZORN
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Publication number: 20240150797Abstract: The present invention lies in the field of food ingredients and concerns a method for the production of dihydrochalcones from various educts as well as the corresponding enzymes, which are used for the production of dihydrochalcones. Furthermore, the present invention concerns transgenic microorganisms and vectors for expressing the enzymes according to the invention.Type: ApplicationFiled: March 3, 2021Publication date: May 9, 2024Applicant: Symrise AGInventors: Torsten Geissler, Jakob Peter Ley, Bastian Zirpel, Dong Yi, Uwe Bornscheuer
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Publication number: 20240130408Abstract: The present invention primarily relates to a process for production of one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulphuric compounds, the process comprising providing a culture medium comprising one or more components supporting growth of a fungus from the phylum Basidiomycota and being convertable to one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulfur aroma compounds; cultivating a fungus from the phylum Basidiomycota in or on the culture medium under conditions that support the growth of the fungus and formation of the one or more flavourings, and optionally recovering the one or more flavourings.Type: ApplicationFiled: February 22, 2021Publication date: April 25, 2024Inventors: Tobias TRAPP, Torsten GEISSLER, Jakob Peter LEY, Jens KOCH, Gerhard KRAMMER, Suzan YALMAN, Marco FRAATZ, Holger ZORN
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Publication number: 20230407349Abstract: The present invention relates to biotechnological methods for the production of saturated as well as unsaturated aldehydes, and mixtures thereof using at least one alpha-dioxygenase and at least one aldehyde dehydrogenase. The method may be carried out either fermentatively or enzymatically. Furthermore, the present invention relates to a vector system, as well as sequences and recombinant microorganisms encoding the enzymes that can be used to produce the aldehydes and mixtures according to the invention. Further, the present invention relates to compositions obtained by the methods according to the present invention.Type: ApplicationFiled: March 12, 2020Publication date: December 21, 2023Inventors: Torsten GEISSLER, Jakob Peter LEY, Michael BACKES, Christoph HARMS, Uwe BORNSCHEUER, Kathleen BALKE, Holger ZORN, Marco Alexander FRAATZ, Andreas HAMMER
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Publication number: 20230279451Abstract: The present invention relates to a biocatalytical method for manufacturing of homoeriodictyol dihydrochalcone and/or hesperetin dihydrochalcone by providing at least one first biocatalyst system for the hydroxylation of phloretin and/or its glycosides as well as at least one second biocatalyst for the methylation of 3-hydroxyphloretin. Further disclosed are microorganisms capable of producing such biocatalysts as well as sequences encoding the biocatalysts. Furthermore, the present invention relates to the use of a mixture obtained by a method as disclosed in the present invention and to specific compositions suitable as sweetness enhancers and/or flavouring agents.Type: ApplicationFiled: September 25, 2020Publication date: September 7, 2023Inventors: Torsten GEISSLER, Jakob Peter LEY, Bastian ZIRPEL
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Publication number: 20220202695Abstract: The present invention relates to a biocatalytic process for producing an aroma substance or a mixture of aroma substances, comprising the steps of: providing a conversion medium comprising a plant component of the gooseber-ry family, the rose family and/or the grapevine family; contacting the conversion medium with at least one fungus from the division of stander fungi capable of forming an aroma substance or a mixture of aroma sub-stances on the conversion medium; converting the plant component to the aroma substance or mixture of aroma substances with the aid of the fungus; and optionally recovering the aroma substance or mixture of aroma substances, wherein the aroma substance or mixture of aroma substances preferably com-prises at least one compound selected from the group consisting of 2-octanone, 2-nonanone, 2-undecanone, linalool oxides, benzaldehyde, geraniol, 2-octanol, methylanthranilate, 2-aminobenzaldehyde and linalool.Type: ApplicationFiled: May 15, 2020Publication date: June 30, 2022Inventors: Holger ZORN, Svenja SOMMER, Nadine SELLA, Christine SCHLERING, Martin RÜHL, Marco FRAATZ, Julia BÜTTNER, Tobias TRAPP, Gerhard KRAMMER, Torsten GEISSLER
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Patent number: 10988786Abstract: The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compound to yield a 3,4-dihydroxyphenyl compound and to biotechnological methods including in vivo and in vitro methods using said enzymes or catalytically active fragments thereof. Further provided is a method either using a suitable oxidase or hydroxylase further enabling the subsequent site specific methylation of the 3,4-dihydroxyphenyl compound in a coupled enzymatic reaction by providing a suitable O-methyltransferase. Finally, compositions obtainable by the aforementioned methods are disclosed.Type: GrantFiled: September 30, 2016Date of Patent: April 27, 2021Assignees: SYMRISE AG, LEIBNIZ-INSTITUT FÜR PFLANZENBIOCHEMIEInventors: Ludger A. Wessjohann, Susann Herrmann, Martin Dippe, Torsten Geissler, Katrin Geissler, Jakob Peter Ley
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Patent number: 10767198Abstract: A method for producing branched aldehydes is proposed, the method comprising the following steps: (a) providing a culture of one or more fungi of the genus Conidiobolus and producing biomass containing branched carboxylic acids in free and/or bound form; (b) extracting the biomass from step (a) to produce a first intermediate containing free and/or bound carboxylic acids; (c) optionally chemically, enzymatically or microbially hydrolyzing the bound carboxylic acids from the first intermediate; (d) treating the first intermediate with a reducing agent of a chemical nature to convert the free and/or bound carboxylic acids into the corresponding alcohols and optionally separating one or more alcohols from interfering by-products and producing the chemically produced second intermediate containing these alcohols as a mixture or in enriched form; (e) treating the first intermediate with a reducing agent of a biological nature to convert the free and/or bound carboxylic acids into the corresponding aldehydes havinType: GrantFiled: November 28, 2015Date of Patent: September 8, 2020Assignee: SYMRISE AGInventors: Marco A. Fraatz, Holger Zorn, Johanna Rost, Michael Goldmann, Egon Gross, Jakob Ley, Katrin Geissler, Torsten Geissler, Michael Backes, Fabia Hentschel, Jens-Michael Hilmer
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Publication number: 20190367954Abstract: A method for producing branched aldehydes is proposed, the method comprising the following steps: (a) providing a culture of one or more fungi of the genus Conidiobolus and producing biomass containing branched carboxylic acids in free and/or bound form; (b) extracting the biomass from step (a) to produce a first intermediate containing free and/or bound carboxylic acids; (c) optionally chemically, enzymatically or microbially hydrolyzing the bound carboxylic acids from the first intermediate; (d) treating the first intermediate with a reducing agent of a chemical nature to convert the free and/or bound carboxylic acids into the corresponding alcohols and optionally separating one or more alcohols from interfering by-products and producing the chemically produced second intermediate containing these alcohols as a mixture or in enriched form; (e) treating the first intermediate with a reducing agent of a biological nature to convert the free and/or bound carboxylic acids into the corresponding aldehydes havinType: ApplicationFiled: November 28, 2015Publication date: December 5, 2019Inventors: Mario FRAATZ, Holger ZORN, Johanna ROST, Michael GOLDMAN, Egon GROSS, Jakob LEY, Katrin GEISSLER, Torsten GEISSLER, Michael BACKES, Fabia HENTSCHEL, Jens-Michael HILMER
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Patent number: 10435673Abstract: A method is proposed for producing flavonoids, comprising the steps: (a) providing of a transgenic microorganism, containing (i) a first nucleic acid section (A), comprising or consisting of a gene coding for a CYP450 oxidase, (ii) a second nucleic acid section (B), comprising or consisting of a gene coding for a plant O-methyltransferase, and (b) adding of one or more flavanones to the transgenic microorganism, (c) the conversion of the substrate flavanones by the transgenic microorganism to the corresponding flavonoids, and optionally (d) isolating and purifying of the final products.Type: GrantFiled: September 27, 2015Date of Patent: October 8, 2019Assignee: SYMRISE AGInventors: Ludger Wessjohann, Anne-Kathrin Bauer, Jakob Ley, Torsten Geissler, Katrin Geissler
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Publication number: 20190289886Abstract: Proposed are mixtures of substances containing (a) phloretin, (b) naringenin, (c) at least one further sweet substance other than phloretin and naringenin, and optionally (d) at least one flavoring substance.Type: ApplicationFiled: December 1, 2015Publication date: September 26, 2019Inventors: Johannes KIEFL, Susanne PAETZ, Jakob LEY, Gerhard KRAMMER, Thomas RIESS, Kathrin LANGER, Günter KINDEL, Morine VERWOHLT, Torsten GEISSLER, Egon GROSS
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BIOTECHNOLOGICAL METHODS FOR PROVIDING 3,4-DIHYDROXYPHENYL COMPOUNDS AND METHYLATED VARIANTS THEREOF
Publication number: 20190194707Abstract: The present invention relates to genetically modified enzymes obtained by rational design of the active site binding pocket of the prototypic enzyme 4-hydroxyphenylacetate 3-hydroxylase (4HPA3H) for hydroxylating a 4-hydroxyphenyl compound to yield a 3,4-dihydroxyphenyl compound and to biotechnological methods including in vivo and in vitro methods using said enzymes or catalytically active fragments thereof. Further provided is a method either using a suitable oxidase or hydroxylase further enabling the subsequent site specific methylation of the 3,4-dihydroxyphenyl compound in a coupled enzymatic reaction by providing a suitable O-methyltransferase. Finally, compositions obtainable by the aforementioned methods are disclosed.Type: ApplicationFiled: September 30, 2016Publication date: June 27, 2019Inventors: Ludger A. WESSJOHANN, Susann HERRMANN, Martin DIPPE, Torsten GEISSLER, Katrin GEISSLER, Jakob Peter LEY -
Patent number: 10227620Abstract: The invention relates to providing both fermentative and biotechnological methods for producing 3,4-methylized cinnamic acids, 3,4-methylized cinnamic acid esters, 3,4-dimethoxyphenethylamine, and 4-methylized cinnamic acid amides using a 4?-O-methyltransferase, optionally in combination with further enzymes, wherein the enzymes are selected by means of metabolic engineering and operation have been adapted by targeted optimization, and compositions obtained by means of the method. The invention further relates to vector systems, recombinant microorganisms or fungi, and specific nucleic acid segments and polypeptides.Type: GrantFiled: February 1, 2016Date of Patent: March 12, 2019Assignee: SYMRISE AGInventors: Gerhard Krammer, Jakob Peter Ley, Katrin Geißler, Torsten Geißler, Frauke Gomoll, Peter Welters, Guido Jach, Ludger Wessjohann
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Publication number: 20160281118Abstract: The invention relates to providing both fermentative and biotechnological methods for producing 3,4-methylized cinnamic acids, 3,4-methylized cinnamic acid esters, 3,4-dimethoxyphenethylamine, and 4-methylized cinnamic acid amides using a 4?-O-methyltransferase, optionally in combination with further enzymes, wherein the enzymes are selected by means of metabolic engineering and operation have been adapted by targeted optimization, and compositions obtained by means of the method. The invention further relates to vector systems, recombinant microorganisms or fungi, and specific nucleic acid segments and polypeptides.Type: ApplicationFiled: February 1, 2016Publication date: September 29, 2016Inventors: GERHARD KRAMMER, JAKOB PETER LEY, KATRIN GEIßLER, TORSTEN GEIßLER, FRAUKE GOMOLL, PETER WELTERS, GUIDO JACH, LUDGER WESSJOHANN