Patents by Inventor Torsten Groth

Torsten Groth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200055835
    Abstract: A compound of the formula I, wherein the symbols are as defined in the remaining specification, or a mixture of two or more compounds of the formula I, for use as active ingredient in the therapeutic—including prophylactic—treatment of a warm-blooded animal for the regulation of body weight (preferred) and/or fat loss (preferred) and/or for the management of obesity and/or for improving the total cholesterol HDL/LDL ratio; where the compound(s) of the formula I may be present in free form, in the form of a pharmaceutically and/or nutraceutically acceptable salt, in the form of tautomers, in the form of esters and/or in the form of solvates, as well as related invention embodiments.
    Type: Application
    Filed: March 21, 2019
    Publication date: February 20, 2020
    Inventors: Torsten Grothe, Ernst Roemer, Philipp Wabnitz
  • Patent number: 10047034
    Abstract: The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-CoA reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-CoA reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: August 14, 2018
    Assignee: Prairie Berry Europe GmbH
    Inventors: Joachim Hans, Torsten Grothe
  • Patent number: 9453016
    Abstract: The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: September 27, 2016
    Inventors: Torsten Grothe, Marc Stadler, Bärbel Köpcke, Ernst Roemer, Jens Bitzer, Philipp Wabnitz, Thomas Küper
  • Publication number: 20150133552
    Abstract: The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-CoA reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-CoA reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention.
    Type: Application
    Filed: May 7, 2013
    Publication date: May 14, 2015
    Inventors: Torsten Grothe, Joachim HANS
  • Patent number: 9005939
    Abstract: The present invention relates to an isolated, recombinant or synthetic polynucleotide encoding a polypeptide with protoilludene synthase activity and comprising a sequence selected from the group consisting of a) SEQ ID Nos. 1 or 14 of the attached sequence listing; b) a nucleic acid sequence complementary to SEQ ID Nos. 1 or 14; c) nucleic acid sequences which hybridize under stringent conditions to the nucleic acid sequences defined in a) and b) or their complementary strands, as well as to the polypeptide encoded by the isolated polynucleotide, as well as a method for the production of melleolides employing the polynucleotide or polypeptide of the invention.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: April 14, 2015
    Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Stefan Jennewein, Benedikt Engels, Torsten Grothe, Marc Stadler
  • Patent number: 8962575
    Abstract: The use or methods of use of extracts comprising one or more special clerodane compounds against inflammatory (including allergic) diseases or conditions, as well as novel compounds of this type, said clerodane derivatives for use against inflammatory (including allergic) diseases or conditions, pharmaceutical formulations comprising them especially for use against inflammatory disease or conditions, and related embodiments; said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disease or condition, as well as their preparation; pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment, and related embodiments.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: February 24, 2015
    Assignee: Biotropics Malaysia Berhad
    Inventors: Matthias Gehling, Torsten Grothe, Ernst Roemer, Peter Reinemer, Kathrin Reinhardt, Annie George, Nur Hanisah Mohtar, Noorsyarida Mohd Sapiai
  • Publication number: 20130338219
    Abstract: The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g.
    Type: Application
    Filed: December 8, 2011
    Publication date: December 19, 2013
    Applicant: Intermed Discovery GMBH
    Inventors: Torsten Grothe, Marc Stadler, Bärbel Köpcke, Ernst Roemer, Jens Bitzer, Philipp Wabnitz, Thomas Küper
  • Publication number: 20130023586
    Abstract: A compound of the formula I, wherein the symbols are as defined in the remaining specification, or a mixture of two or more compounds of the formula I, for use as active ingredient in the therapeutic—including prophylactic—treatment of a warm-blooded animal for the regulation of body weight (preferred) and/or fat loss (preferred) and/or for the management of obesity and/or for improving the total cholesterol HDL/LDL ratio; where the compound(s) of the formula I may be present in free form, in the form of a pharmaceutically and/or nutraceutically acceptable salt, in the form of tautomers, in the form of esters and/or in the form of solvates, as well as related invention embodiments.
    Type: Application
    Filed: January 13, 2011
    Publication date: January 24, 2013
    Applicant: INTERMED DISCOVERY GMBH
    Inventors: Torsten Grothe, Ernst Roemer, Philipp Wabnitz
  • Publication number: 20120058172
    Abstract: Compounds obtainable from plants, e.g. of the genus Eucalyptus, or from microorganisms are shown to be useful as CNS activity modulators useful e.g. in the treatment of depression, for lifting mood and/or for increasing behavioural initiative and the like. This use and related aspects form embodiments of the invention. Also compounds as such are presented. The compounds useful are acylphloroglucine derivatives of the formula I, wherein the substituents are as defined in the description.
    Type: Application
    Filed: November 11, 2011
    Publication date: March 8, 2012
    Applicant: Intermed Discovery GmbH
    Inventors: Ernst Roemer, Torsten Grothe
  • Publication number: 20110213026
    Abstract: The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, of an extract and/or one or more natural compounds from plants or parts of plants, respectively, from a genus selected from the group consisting of Schisandra, Illicium, Kadsura, Steganotaenia and Magnolia, alone or as supplement, as active ingredient in the regulation of body weight and/or fat loss and/or for the management of obesity, either in humans or in animals, to the use of said extract and/or natural compound(s) or mixtures in the manufacture of a pharmaceutical or nutraceutical formulation for the regulation of body weight and/or fat loss and/or for the management of obesity either in humans or in animals. The above extract and/or compound(s) can further be used to reduce one or more adverse metabolic parameters in a subject.
    Type: Application
    Filed: July 29, 2008
    Publication date: September 1, 2011
    Applicant: INTERMED DISCOVERY GMBH
    Inventors: Torsten Grothe, Ernst Roemer, Thomas Henkel
  • Publication number: 20110021613
    Abstract: Compounds obtainable from plants, e.g. of the genus Eucalyptus, or from microorganisms are shown to be useful as CNS activity modulators useful e.g. in the treatment of depression, for lifting mood and/or for increasing behavioural initiative and the like. This use and related aspects form embodiments of the invention. Also compounds as such are presented. The compounds useful are acylphloroglucine derivatives of the formula I, wherein the substituents are as defined in the description.
    Type: Application
    Filed: December 11, 2007
    Publication date: January 27, 2011
    Applicant: INTERMED DISCOVERY GMBH
    Inventors: Ernst Roemer, Torsten Grothe
  • Publication number: 20100267823
    Abstract: The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with a phosphodiesterase (PDE) dependent disease or condition of the central nervous system, as well as methods, uses and other inventions related thereto.
    Type: Application
    Filed: March 29, 2010
    Publication date: October 21, 2010
    Inventors: Annie George D/O V.K. George, Bärbel Köpcke, Ernst Roemer, Jens Bitzer, Joerg Gruenwald, Matthias Gehling, Philipp Wabnitz, Tengku Shahrir bin Tengku Adnan, Torsten Grothe
  • Publication number: 20100267822
    Abstract: The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with an estrogen receptor (ER) related disease or condition of the animal or human body, as well as methods, uses and other inventions related thereto.
    Type: Application
    Filed: March 29, 2010
    Publication date: October 21, 2010
    Inventors: Annie George D/O V.K. George, Bärbel Köpcke, Ernst Roemer, Jens Bitzer, Joachim Hans, Joerg Gruenwald, Matthias Gehling, Philipp Wabnitz, Tengku Shahrir bin Tengku Adnan, Torsten Grothe
  • Patent number: 7767428
    Abstract: This invention provides a salutaridinol 7-O-acetyltransferase protein, a salutaridinol 7-O-acetyltransferase gene, and a sequence which is complementary thereto. This invention further provides a method for the production of thebaine comprising the steps of (i) contacting in vitro a protein having salutaridinol 7-O-acetyltransferase activity with salutaridinol and acetyl coenzyme A at pH 8 to 9, and (ii) recovering the thebaine thus produced.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: August 3, 2010
    Assignee: Donald Danforth Plant Science Center
    Inventors: Toni M. Kutchan, Meinhart H. Zenk, Torsten Grothe
  • Publication number: 20090053764
    Abstract: This invention provides a protein comprising consecutive amino acids, the amino acid sequence of which is illustrated in FIG. 8 (SEQ. ID No. 14) or, a fragment thereof having at least 15 amino acids, or a variant thereof, the sequence of which has at least 70% identity with the amino acid sequence of FIG. 8 (SEQ. ID No. 14) over a length of at least 400 amino acids. This invention further provides a peptide comprising a fragment of salutaridinol 7-O-acetyltransferase protein of at least 6 consecutive amino acids which is not present in other plant acetyltransferases as illustrated in FIG. 2 (SEQ. IDs No. 8 to 12). This invention further provides a nucleic acid molecule comprising consecutive nucleotides (i) the nucleic acid sequence of which is illustrated in FIG. 9 (SEQ. ID No. 13) or FIG. 10 (SEQ. ID No. 15), or (ii) a fragment thereof having a length of at least 45 nucleotides, or (iii) a variant thereof, the sequence of which has at least 70% identity with the sequence of FIG. 9 (SEQ. ID No. 13) or FIG.
    Type: Application
    Filed: May 15, 2008
    Publication date: February 26, 2009
    Applicant: DONALD DANFORTH PLANT SCIENCE CENTER
    Inventors: Toni M. Kutchan, Meinhart H. Zenk, Torsten Grothe
  • Patent number: 7390642
    Abstract: This invention provides: (A) a protein the sequence of which is in FIG. 8 (SEQ. ID n° 14), or a fragment thereof having at least 15 amino acids, or a variant thereof, having at least 70% identity with FIG. 8 (SEQ. ID n° 14) over a length of at least 400 amino acids; (B) a peptide comprising a fragment of salutaridinol 7-O-acetyltransferase of at least 6 consecutive amino acids not present in other plant acetyltransferases as in FIG. 2 (SEQ. IDs n° 8 to 12); (C) a nucleic acid (i) the sequence of which is in FIG. 9 (SEQ. ID n° 13) or FIG. 10 (SEQ. ID n° 15), or (ii) a fragment thereof of at least 45 nucleotides, or (iii) a variant thereof, having at least 70% identity with FIG. 9 (SEQ. ID n° 13) or FIG. 10 (SEQ.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: June 24, 2008
    Assignee: Donald Danforth Plant Science Center
    Inventors: Toni M. Kutchan, Meinhart H. Zenk, Torsten Grothe
  • Publication number: 20070118000
    Abstract: The invention relates to a process for the preparation of iminodisuccinic acid ammonium metal salts, characterized in that, in a first stage, maleic anhydride (MA), alkali metal hydroxide and water are mixed in the molar ratio of 2:0-3:5-30 and then ammonia is metered in in the ratio MA:ammonia 2:1.5-8, in order to obtain iminodisuccinic acid ammonium salts which, in a second stage, are reacted with metal oxides, metal hydroxides (and) or other metal salts or their mixtures to give iminodisuccinic acid ammonium metal salts of the formula 8, IDA(NH4)x(Na)y(K)z(Me)m.(NH3)n??Formula 8 in which IDA represents iminodisuccinic acid anion, x=0.1-3.9 y=0-3 z=0-3 m=0.1-2 n=0-6 and Me represents metals of the IInd, IIIrd and IVth main groups and of the Ist to VIIIth subgroups as well as metals of the lanthanide series, of the Periodic Table, which can occur in the oxidation states 1, 2, 3 or 4, the compounds themselves and their intermediates, and the use.
    Type: Application
    Filed: January 12, 2007
    Publication date: May 24, 2007
    Inventors: Torsten Groth, Alfred Mitschker, Ralf-Johann Moritz, Thomas Klein, Thomas Menzel, Wolfgang Wirth
  • Patent number: 7183429
    Abstract: The invention relates to a process for the preparation of iminodisuccinic acid ammonium metal salts, characterized in that, in a first stage, maleic anhydride (MA), alkali metal hydroxide and water are mixed in the molar ratio of 2:0–3:5–30 and then ammonia is metered in in the ratio MA: ammonia 2:1.5–8, in order to obtain iminodisuccinic acid ammonium salts which, in a second stage, are reacted with metal oxides, metal hydroxides (and) or other metal salts or their mixtures to give iminodisuccinic acid ammonium metal salts of the formula 8, IDA(NH4)x(Na)y(K)z(Me)m.(NH3)nFormula 8 in which IDA represents iminodisuccinic acid moiety, x=0.1–3.9 y=0–3 z=0–3 m=0.1–2 n=0–6 and Me represents metals of the IInd, IIIrd and IVth main groups and of the Ist to VIIIth subgroups as well as metals of the lanthanide series, of the Periodic Table, which can occur in the oxidation states 1, 2, 3 or 4, the compounds themselves and their intermediates and the use.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: February 27, 2007
    Assignee: Lanxess Deutschland GmbH
    Inventors: Torsten Groth, Alfred Mitschker, Ralf-Johann Moritz, Thomas Klein, Thomas Menzel, Wolfgang Wirth
  • Publication number: 20060020121
    Abstract: The invention relates to a process for preparing ytterbium(III) ?-diketonates, especially ytterbium(III) acetylacetonate, to the ytterbium(III) ?-diketonates prepared by this process and to the use thereof as catalysts.
    Type: Application
    Filed: July 15, 2005
    Publication date: January 26, 2006
    Inventors: Arne Gerlach, Torsten Groth, Steffen Hofacker
  • Patent number: 6743372
    Abstract: The present invention relates to compositions for water treatment based on biodegradable polymers containing repeating succinyl units, biocidal oxidizing agents and unsubstituted or substituted amidosulphonic acid, their use in, and the process for, conditioning water of cooling circuits.
    Type: Grant
    Filed: February 13, 2001
    Date of Patent: June 1, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Roland Kleinstück, Torsten Groth, Winfried Joentgen